Email this article GENDER SPECIFIC CHANGES IN MOUSE BLOOD ESTRERASE PROFILE AT THE ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2-BENZODIOXAPHOSPHORIN-2-OXIDE
- Authors: Prokofieva D.S.1, Shmurak V.I.1, Bodryakova E.A.1, Voitenko N.G.1
-
Affiliations:
- Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia
- Issue: No 1 (2017)
- Pages: 47-51
- Section: Articles
- Published: 28.02.2017
- URL: https://rjpbr.com/0869-7922/article/view/641014
- DOI: https://doi.org/10.36946/0869-7922-2017-1-47-51
- ID: 641014
Cite item
Full Text
Abstract
A comparative investigation of the esterase profiles of blood of mice of both genders exposed to various doses of 2-(o-crezyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) was made an hour after its percutaneous injection to animals. A lesser amount of esterase in males blood made them more susceptible to CBDP action as compared to females. It was shown that CBDP equally inhibits the activity of carboxyl esterase and butyryl choline esterase in blood serum of both male and female mice. Statistically significant differences in inhibition degree of enzymes between males and females were found out and therefore it is not recommended to use mixed groups of animals when performing testing of serine esterase inhibitors.
About the authors
D. S. Prokofieva
Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia
Author for correspondence.
Email: darija-p1@yandex.ru
188663, Saint Petersburg Russian Federation
V. I. Shmurak
Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia
Email: vladimir.shmurak@gmail.com
188663, Saint Petersburg Russian Federation
E. A. Bodryakova
Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia
Email: bodalena@yandex.ru
188663, Saint Petersburg Russian Federation
N. G. Voitenko
Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency of Russia
Email: ngvoitenko@gmail.com
188663, Saint Petersburg Russian Federation
References
- Li B., Sedlacek M., Manoharan I., Boopathy R., Duysen E.G., Masson P., Lockridge O. Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem. Pharmacol. 2005; 70(11):1673-84.
- Bahar F.G., Ohura K., Ogihara T., Imai T. Species Difference of Esterase Expression and Hydrolase Activity in Plasma. J. Pharm. Sci. 2012; 101(10):3979-88.
- Berry l.M., Wollenberg l., Zhao Z. Esterase activities in the blood, liver and intestine of several preclinical species and humans. Drug Metab. Lett. 2009; 3(2):70-77.
- Bełtowski J., Wójcicka G., Marciniak A. Species- and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration. Acta Biochim. Pol. 2002; 49(4):927-936.
- Clement J G., Erhardt N. Serum carboxylesterase activity in various strains of rats: sensitivity to inhibition by CBDP (2-/o-cresyl/4H:1:3:2-benzodioxaphosphorin2-oxide). Arch. Toxicol. 1990; 64(5): 414– 416.
- Duysen E.G., Koentgen F., Williams G.R., timperley c.m., schopfer l.m., cerasoli d.m., lockridge o. Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. Chem. Res. Toxicol. 2011; 24(11): 1891-1898.
- Garrett T.l., Rapp C.M., Grubbs R.D., Schlager J.J., lucot J.B. A murine model for sarin exposure using the carboxylesterase inhibitor CBDP. Neurotoxicology. 2010; 31(5):502-8.
- Maxwell D.M., Brecht K.M., Lenz D.E., O’Neill B.L. Effect of carboxylesterase inhibition on carbamate protection against soman toxicity. J. Pharmacol. Exp. Ther. 1988; 246(3):986-991.
- Clement J.G. Importance of aliesterase as a detoxification mechanism for soman (Pinacolyl methylphosphonofluoridate) in mice. Biochem. Pharmacol. 1984; 33(23):3807-3811.
- Jokanović M. Role of carboxylesterase in soman, sarin and tabun poisoning in rats. Pharmacol. Toxicol. 1989;65(3):181-184.
- Yang Z.P.,DettbarnW-D. Prevention of Tolerance to the Organophosphorus Anticholinesterase Paraoxon with Carboxylesterase Inhibitors. Biochemical. Pharmacology. 1998; 55(9): 1419–1426.
- Tuovinen K.,Kaliste-Korhonen E.,Hänninen O. Gender differences in activities of mouse esterase and sensitivities to DFP and sarin toxicity. Gen. Pharmacol. 1997; 29(3): 333-5.
- Wehner J.M., Murphy-Erdosh C., Smolen A., Smolen T.N. Genetic variation in paraoxonase activity and sensitivity to diisopropylphosphofluoridate in inbred mice. Pharmacol. Biochem. Behav. 1987;28(2):317-20.
- Djeridane A., Yousfi M., Nadjemi B., Maamri S., Djireb F., Stocker P. Phenolic extracts from various Algerian plants as strong inhibitors of porcine liver carboxylesterase. J. Enzyme Inhib. Med. Chem. 2006; 21(6):719- 26.
- Nomeir A.A., Abou-Sonia M.B. Studies on the metabolism of neurotoxic tri-o-cresyl phosphate. Toxicology. 1986; 38: 1-13.
Supplementary files
