Prospects for the use of genistein for the treatment of poisoning with hepatotoxic chemicals (literature review)

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Abstract

Introduction. The search for new highly effective medicines with a wide range of pharmacological effects and low toxicity is one of the priorities of the development of modern pharmacy and medicine. The development of medicines intended for the treatment of poisoning by chemical substances of hepatotoxic action remains actual. Substances of plant origin, in particular genistein, are of great interest in this regard.

Material and methods. The material for the analysis was the sources of literature, abstracting in the bibliographic databases of PubMed, Scopus, and RSCI.

Results. The article discusses the results of domestic and foreign studies devoted to the study of the biological effect of genistein. Its structure, toxicity and mechanisms of action are described. The results of studies confirming the effectiveness of genistein in protecting the liver, as well as in reducing the toxic effects on this organ in case of poisoning, are considered. A section is highlighted that examines the possibility of using genistein in various medical fields and its potential for the prevention and treatment of pathologies caused by hepatotoxicants.

Limitations. The review was prepared based on a study of 44 literature sources published over the period from 1998 to 2023, which represents a fairly representative sample.

Conclusion. Genistein, which has a pronounced antioxidant activity, can potentially be used to treat poisoning with chemicals, in the mechanism of toxic action of which oxidative stress plays an important role, primarily hepatotoxicants.

Аuthors сontribution:
Erlin G.V. — collection of material in bibliographic databases, material analysis, writing the text of the article;
Strelova O.Yu. — material analysis, text processing and editing;
Grebenyuk A.N. — the concept and design of the study, material analysis, text processing and editing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interests. The authors declare no conflict of interest.

Funding. The study had no sponsorship.

Received: December 27, 2023 / Accepted: March 10, 2024 / Published: April 27, 2024

About the authors

Gleb V. Erlin

Saint Petersburg State Chemical and Pharmaceutical University

Author for correspondence.
Email: gleb.erlin@spcpu.ru
ORCID iD: 0009-0006-2202-7919

1st year postgraduate student in toxicology, Department of Pharmaceutical Chemistry, Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russian Federation

e-mail: gleb.erlin@spcpu.ru

Russian Federation

Olga Yu. Strelova

Saint Petersburg State Chemical and Pharmaceutical University

Email: olga.strelova@pharminnotech.com
ORCID iD: 0000-0001-6737-1023

Doctor of Pharmaceutical Sciences, Associate Professor, Head of the Department of Pharmaceutical Chemistry, Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russian Federation

e-mail: olga.strelova@pharminnotech.com

Russian Federation

Aleksandr N. Grebenyuk

Saint Petersburg State Chemical and Pharmaceutical University; Pavlov First Saint Petersburg State Medical University (Pavlov University

Email: grebenyuk_an@mail.ru
ORCID iD: 0000-0002-9381-194X

Doctor of Medical Sciences, Professor of the Department of Pharmaceutical Chemistry, Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg. Professor of the Department of Mobilization Training of Healthcare and Disaster Medicine of the Federal State Budgetary Educational Institution of Higher Education “First Pavlov State Medical University of St. Petersburg" Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation

e-mail: grebenyuk_an@mail.ru

Russian Federation

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