Effect of subchronic use of sodium nitrite on the functional parameters of an isolated rat heart
- Авторлар: Laptev D.S.1, Petunov S.G.1, Nechaykina O.V.1, Bobkov D.V.1
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Мекемелер:
- Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
- Шығарылым: № 2 (2022)
- Беттер: 102-107
- Бөлім: Original Study
- ##submission.datePublished##: 21.04.2022
- URL: https://rjpbr.com/0869-7922/article/view/641416
- DOI: https://doi.org/10.47470/0869-7922-2022-30-2-102-107
- ID: 641416
Дәйексөз келтіру
Толық мәтін
Аннотация
Introduction. The active development of agriculture with the widespread use of nitrogen-containing fertilizers, increased consumption of processed meat products containing sodium nitrite as a preservative, inevitably leads to an increase in the nitrogen load on the human body and can cause the development of cardiovascular diseases.
Materials and methods. The cardiotoxic effect of sodium nitrite was evaluated on a model of an isolated rat heart with subchronic intragastric administration for 28 days at doses of 0.03; 0.3; 3.0 mg/kg.
Results. The use of sodium nitrite leads to dilation of the coronary vessels and myocardium, inhibition of the contractile activity of the heart, disruption of its electrical activity in the form of a shortening of the QT interval associated with an increased risk of ventricular fibrillation, and a tendency to increase the amplitude of the T wave, which indicates myocardial ischemia. In a stress test with total ischemia, it was revealed that the magnitude of the change in the parameters characterizing the restoration of myocardial function under reperfusion conditions is inversely proportional to the dose of sodium nitrite used.
Limitations. The study was performed only on male white rats more prone to the development of cardiovascular pathology.
Conclusion. With subchronic administration, sodium nitrite has cardiotoxicity at a dose of 0.028 mg/kg, which is twice lower than the WHO-established permissible daily intake for humans (0.06 mg/kg).
Авторлар туралы
Denis Laptev
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Хат алмасуға жауапты Автор.
Email: lapden@mail.ru
ORCID iD: 0000-0002-3960-3058
Candidate of Biological Sciences, Head of the Laboratory of “Extreme Physiology “of Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA of Russia, Leningrad region, 188663, Russian Federation.
e-mail: lapden@mail.ru
РесейSergey Petunov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: sergey-petunov@mail.ru
ORCID iD: 0000-0001-6781-8315
Кандидат медицинских наук, доцент, заведующий научно-организационным отделом ФГУП НИИ ГПЭЧ ФМБА России, 188663, Ленинградская область.
e-mail: sergey-petunov@mail.ru
РесейOlga Nechaykina
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: olga2278@mail.ru
ORCID iD: 0000-0001-7151-7240
Старший научный сотрудник лаборатории экстремальной физиологии ФГУП НИИ ГПЭЧ ФМБА России, 188663, Ленинградская область.
e-mail: olga2278@mail.ru
РесейDmitriy Bobkov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: bdv21@yandex.ru
ORCID iD: 0000-0003-3989-0437
Старший научный сотрудник лаборатории экстремальной физиологии ФГУП НИИ ГПЭЧ ФМБА России, 188663, Ленинградская область.
e-mail: bdv21@yandex.ru
РесейӘдебиет тізімі
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