EXPERIMENTAL EVALUATION OF THE ELECTROMAGNETIC RADIATION PROTECTIVE ACTION AGAINST HYDRAZINE TOXICITY EFFECT

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Abstract

It was found out that the exposure of rats to asymmetric dimethylhydrazine in a dose of 100 mg/kg leads to acute functional disorders of the central nervous system, toxic lesion of a number of vitally important organs during the two first hours. During the first 4 hours of intoxication, the survival of rats in control groups was 10% to 60%, a day after it did not exceed 20% and in some cases 100% lethality was already observed in the first hours of intoxication. The preventive exposure to electromagnetic radiation modulated by the preparation with the tissue of the brain pituitary-hypothalamic part in newborn infant rat (P1-4) over 4 days with a total exposition of 270 min. increased the rat resistance to the toxic action of asymmetric dimethylhydrazine. In that case the survival of rats over the first 4 hours of intoxication was of 80-90% and a day after lowered up to 40-70%. The corrective action of the given type of radiation with a total exposure time of 150 min. also increased the rat resistance to toxic effect of asymmetric dimethylhydrazine in the indicated dose. In that case the survival in the first 4 hours of intoxication was 80%-90% and 50%-80%. during the first days of intoxication.

About the authors

Anna Aleksandrovna Kokaya

Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory

Author for correspondence.
Email: noemail@neicon.ru

Кандидат медицинских наук, старший научный сотрудник отдела нейрофизиологии и экспериментального моделирования ГБОУ ВПО «Нижегородская государственная медицинская академия» Министерства здравоохранения России, ЦНИЛ, 603004, г. Нижний Новгород

e-mail: kann9988@gmail.com

Russian Federation

Vladimir Pavlovich Kozyakov

Research Institute of Occupational Pathology and Human Ecology of the Federal Medical-Biological Agency of Russia

Email: noemail@neicon.ru

Доктор медицинских наук, главный научный сотрудник научно-организационного отдела ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, Ленинградская область, Всеволожский район, г.п. Кузьмоловский

e-mail: wpk@bk.ru

Russian Federation

Irina Vasyevna Mukhina

Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory

Email: noemail@neicon.ru

Доктор биологических наук, профессор, заведующий кафедрой нормальной физиологии ГОУ ВПО «Нижегородская государственная медицинская академия» Министерства здравоохранения России, ЦНИЛ, 603004, г. Нижний Новгород,

e-mail: mukchinaiv@mail.ru

Russian Federation

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