Email this article EXPERIMENTAL EVALUATION OF THE ELECTROMAGNETIC RADIATION PROTECTIVE ACTION AGAINST HYDRAZINE TOXICITY EFFECT
- Authors: Kokaya A.A.1, Kozyakov V.P.2, Mukhina I.V.1
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Affiliations:
- Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory
- Research Institute of Occupational Pathology and Human Ecology of the Federal Medical-Biological Agency of Russia
- Issue: No 6 (2014)
- Pages: 28-35
- Section: Articles
- Published: 22.12.2014
- URL: https://rjpbr.com/0869-7922/article/view/641390
- DOI: https://doi.org/10.15690/vramn546
- ID: 641390
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Abstract
It was found out that the exposure of rats to asymmetric dimethylhydrazine in a dose of 100 mg/kg leads to acute functional disorders of the central nervous system, toxic lesion of a number of vitally important organs during the two first hours. During the first 4 hours of intoxication, the survival of rats in control groups was 10% to 60%, a day after it did not exceed 20% and in some cases 100% lethality was already observed in the first hours of intoxication. The preventive exposure to electromagnetic radiation modulated by the preparation with the tissue of the brain pituitary-hypothalamic part in newborn infant rat (P1-4) over 4 days with a total exposition of 270 min. increased the rat resistance to the toxic action of asymmetric dimethylhydrazine. In that case the survival of rats over the first 4 hours of intoxication was of 80-90% and a day after lowered up to 40-70%. The corrective action of the given type of radiation with a total exposure time of 150 min. also increased the rat resistance to toxic effect of asymmetric dimethylhydrazine in the indicated dose. In that case the survival in the first 4 hours of intoxication was 80%-90% and 50%-80%. during the first days of intoxication.
About the authors
Anna Aleksandrovna Kokaya
Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory
Author for correspondence.
Email: noemail@neicon.ru
Кандидат медицинских наук, старший научный сотрудник отдела нейрофизиологии и экспериментального моделирования ГБОУ ВПО «Нижегородская государственная медицинская академия» Министерства здравоохранения России, ЦНИЛ, 603004, г. Нижний Новгород
e-mail: kann9988@gmail.com
Russian FederationVladimir Pavlovich Kozyakov
Research Institute of Occupational Pathology and Human Ecology of the Federal Medical-Biological Agency of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, главный научный сотрудник научно-организационного отдела ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, Ленинградская область, Всеволожский район, г.п. Кузьмоловский
e-mail: wpk@bk.ru
Russian FederationIrina Vasyevna Mukhina
Medical University, Nizhny Novgorod State Medical Academy, Russian Ministry of Health, Central Research Laboratory
Email: noemail@neicon.ru
Доктор биологических наук, профессор, заведующий кафедрой нормальной физиологии ГОУ ВПО «Нижегородская государственная медицинская академия» Министерства здравоохранения России, ЦНИЛ, 603004, г. Нижний Новгород,
e-mail: mukchinaiv@mail.ru
Russian FederationReferences
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