Email this article CORRECTION WITH «TAUCINE» OF HEPATOTOXICITY PARAMETERS IN PLASMA OF RATS WITH CHOLESTASIS
- Authors: Pashko A.U.1, Bushma K.M.2,3, Borisenok O.A.1, Bushma M.I.1
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Affiliations:
- Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of the Republic of Belarus
- Educational Institution «Grodno State Medical University»
- Chair of Anaesthesiology and Intensive Care , Ministry of Health of the Republic of Belarus
- Issue: No 3 (2015)
- Pages: 12-15
- Section: Articles
- Published: 12.06.2015
- URL: https://rjpbr.com/0869-7922/article/view/641301
- DOI: https://doi.org/10.15690/vramn453
- ID: 641301
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Abstract
In rats with liver cholestatic injury ( common bile duct ligation during 13 days), a combination of taurine with zinc diaspartate in the ratio of 50 g/mole to 1 g/mole. («taucine-50») in dose of 0.5 g/kg shows a hepatoprotective effect judging from improvement of marker biochemical indicators of hepatotoxicity in plasma. As the period of cholesterase increases up to 21 days and hepatopathy is worsenig, «taucine-20» in the above mentioned dose also produces an equivalent hepatoprotective effect.
About the authors
Anastasiya Urjevna Pashko
Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of theRepublic of Belarus
Author for correspondence.
Email: noemail@neicon.ru
Ассистент и аспирант кафедры фармакологии им. профессора М.В. Кораблева УО «Гродненский государственный медицинский университет» МЗ Республики Беларусь, 230005, г. Гродно, Республика Беларусь
e-mail: anfstas@inbox.ru
BelarusKiryll Mikhailovich Bushma
Educational Institution «Grodno State Medical University»; Chair of Anaesthesiology and Intensive Care , Ministry of Health of the Republic of Belarus
Email: noemail@neicon.ru
Кандидат медицинских наук, доцент кафедры анестезиологии и реаниматологии, 230017, г. Гродно, Республика Беларусь
BelarusOlga Alexandrovna Borisenok
Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of theRepublic of Belarus
Email: noemail@neicon.ru
Кндидат медицинских наук, ассистент кафедры фармакологии им. профессора М.В. Кораблева УО «Гродненский государственный медицинский университет» МЗ Республики Беларусь, 230005, г. Гродно, Республика Беларусь
BelarusMihail Ivanovich Bushma
Educational Institution «Grodno State Medical University» M.V. Korablev Chair of Pharmacology, Ministry of Health of theRepublic of Belarus
Email: noemail@neicon.ru
Доктор медицинских наук, профессор кафедры фармакологии им. профессора М.В. Кораблева УО«Гродненский государственный медицинский университет» МЗ Республики Беларусь, 230005, г. Гродно, Республика Беларусь
e-mail: pharma@grsmu.by
BelarusReferences
- Mashkovskij M.D. Drugs. Moskva: Novaja volna; 2005 (in Russian).
- But-Gusaim L.St., Gerashchenko N.V., Bloshko T.E. Prospects of use of preparations of zinc in a perinatologi. Materialy nauchnoprakticheskoy konferentsii posvyashchennoy 60 let sluzhbe skoroy pomoshchi i 10 let UZ «GKO SMP». 5-7 sentyabrya 2005. Grodno: GrGMU; 2005 (in Russian).
- Truong-Tran A.Q. et al. The role of zinc in caspase activation and apoptotic cell death. Biometals. 2001; 14:315-330.
- Schumann G. et al. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. Part 3. Reference procedure for the measurement of catalytic concentration of lactate dehydrogenase. Clin. Chem. Lab. Med. 2002; 40: 643-648.
- Gavrilov V.B., Mishkorudnaya M.I. Spectrophotometric determination of lipid hydroperoxide content in the plasma of blood. Laboratornoye delo. 1983; 3: 33-36 (in Russian).
- Kamyshnikov V.S. Handbook of clinical and biochemical laboratory diagnosis T. 2. Minsk: «Belarus’»; 2002 (in Russian).
- Rebrova O.Yu. Statistical analysis of medical data. Moskva: MediaSfera; 2002 (in Russian).
- Stiehi A. Disturbances of bile acid metabolism on cholestasis. Clin. Gastroenterol. 1977; 6: 35-67.
- Harada H. et al. Oral taurine supplementation prevents the development of ethanol-induced hypertension in rats. Hypertens Res. 2000; 23: 277-284.
- Formigari A., Irato P., Santon A. Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects. Comp. Biochem. Physiol. Pt. C. 2007; 146: 443-459.
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