ABOUT THE POSSIBILITY OF TOXIC EFFECTS DEVELOPING IN CONTACT WITH N-NITROSOALKYLUREA DERIVATIVE - LYSOMUSTINE

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Abstract

The paper presents the results of a study on the possibility of toxic effects developing in contact with the antitumor drug – lysomustine - to assess the health risk in the manufacture of the finished dosage form and its use. The work was performed on 40 outbred rats, 40 guinea pigs and 114 outbred mice. The experimental study has showed that lysomustine does not irritate intact skin, is not a potential allergen, has no skin-resorptive effect, does not cause reproductive disorders. The drug reveales mutagenic properties inherent in many cytostatics, representatives of the class of N-nitrosoalkylureas. The research results allow to conclude that the presence of the drug in the air of industrial premises and on the skin of workers in its manufacture and use of the finished dosage form is unacceptable.

About the authors

K. I. Stosman

Institute of Toxicology of the Federal Medical Biological Agency

Author for correspondence.
Email: kira.stosman@influenza.spb.ru

Stosman Kira Iosiphovna

192019, Saint Petersburg

Russian Federation

L. V. Lukovnikova

Institute of Toxicology of the Federal Medical Biological Agency

Email: lukovnikova.l.v@toxicology.ru

Lukovnikova Lubov Vladimirovna

192019, Saint Petersburg

Russian Federation

G. I. Sidorin

Institute of Toxicology of the Federal Medical Biological Agency

Email: sidorin.g@mail.ru

Sidorin Gennadij Ivanovich

192019, Saint Petersburg

Russian Federation

L. I. Dyakova

Institute of Toxicology of the Federal Medical Biological Agency

Email: fake@neicon.ru

Dyakova Lyudmila Ivanovna

192019, Saint Petersburg

Russian Federation

E. P. Zatsepin

Institute of Toxicology of the Federal Medical Biological Agency

Email: fake@neicon.ru

Zatsepin Eduard Pavlovich

192019, Saint Petersburg

Russian Federation

G. V. Shestova

Institute of Toxicology of the Federal Medical Biological Agency

Email: fake@neicon.ru
Shestova Galina Vladimirovna

192019, Saint Petersburg

Russian Federation

B. S. Litvintsev

Institute of Toxicology of the Federal Medical Biological Agency

Email: fake@neicon.ru

Litvintsev Bogdan Sergeevich

192019, Saint Petersburg

Russian Federation

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Copyright (c) 2020 Stosman K.I., Lukovnikova L.V., Sidorin G.I., Dyakova L.I., Zatsepin E.P., Shestova G.V., Litvintsev B.S.



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