BIOLOGICAL ASSESSMENT OF THE IMPACT OF ALUMINUM OXIDE MICROAND NANOPARTICLES ON THE ORGANISM OF LABORATORY ANIMALS IN CONDITIONS OF ACUTE TOXICITY
- Authors: Ignatova A.M.1, Zemlyanova M.A.1
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Affiliations:
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
- Issue: No 3 (2020)
- Pages: 33-40
- Section: Competition of scientific works of young scientists and specialists
- Published: 24.06.2020
- URL: https://rjpbr.com/0869-7922/article/view/641247
- DOI: https://doi.org/10.36946/0869-7922-2020-3-33-40
- ID: 641247
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Abstract
Aluminum oxide nanoparticles widely used in the production are part of many consumer goods, such as pharmaceuticals, food additives etc. The study of the biological hazard of aluminum oxide is of greatest relevance to other aluminum compounds, and the increasing demand for aluminum oxide nanomaterials emphasizes the need to identify specific mechanisms of action of its nanoparticles in comparison with larger micro-sized analogues.
It has been found that a specific response from the nervous system to a single intragastric injection of aluminum oxide nanoparticles was a change in the morphometric parameters of the neurons of the granular layer and basket neurons of the molecular layer of the cerebellum of the brain, so the size of the neurons of the granular layer of the cerebellum in rats increases by 1,2 times and the size of the basket neurons of the molecular layer of the cerebellum in rats decreases by 1,1 times relative to similar indicators when exposed to microparticles.
In case of intragastric administration of the aluminum oxide nanoparticles, the blood filling of sinusoid spaces of liver tissues, thrombosis progressing without visible compensatory changes, and damage to the nuclei of hepatocytes occur in comparison to an increase in the proportion of sinusoid spaces of liver tissues without a sharp increase in blood accumulations and apoptosis of hepatocytes at the level of 3% specific to the injection of aluminum oxide microparticles.
The nature of the liver tissue reaction depends on the total specific surface area of the active particles: when exceeding the value of 80 m2, reactions specific for the action of nanoparticles are manifested.
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About the authors
A. M. Ignatova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Author for correspondence.
Email: iampstu@gmail.com
Ignatova Anna Mikhailovna
614000, Perm
Russian FederationM. A. Zemlyanova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: fake@neicon.ru
Zemlyanova Marina Aleksandrovna
614000, Perm
Russian FederationReferences
- Bange D, Gary R; Kirk-Othmer Encyclopedia of Chemical Technology. (2002). NY, NY: John Wiley & Sons; Abrasives. Online Posting Date: December 20, 2002.
- O’Neil M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 61.
- Vakalova T.V., Habas T.A., Erdman S.V., Vereshchagin V.I. Workshop on the basics of the technology of refractory non-metallic and silicate materials. – Tomsk: Izd. TPU, 1999. 160 p. (in Russian).
- Englert N. Fine particles and human health-a review of epidemiological studies. Toxicol. Lett. 2004; 149: Pp. 235–242.
- EPA (Environmental Protection Agency) National ambient air quality standards for particulate matter; final rule. Fed Reg. 1997; 62: 38651.
- Leigh HD; Kirk-Othmer Encyclopedia of Chemical Technology. (1997). NY: John Wiley & Sons; Refractories. Online Posting Date: December 4, 200.
- IAI (International Aluminium Institute) Alternative source data, Aluminium recovered from purchased or tolled scrap. 2005. [online] Cited 27 November 2005 Available from www.world-aluminium.org/iai/stats/.
- Ignatova A.M., Zemlyanova M.A., Stepanko M.S., Ignatov M.N. Determination of morphometric characteristics of the microdisperse system of aluminum oxide by image analysis. // Software systems and computational methods. - 2017. – No. 3. - Pp. 70-85. (in Russian).
- Shevtsov P.N. Influence of aluminum ions on phosphorylation of tubulin and microtular proteins of the brain / P.N. Shevtsov, G.Sh. Burbaeva // Korsakov journal of neurology and psychiatry. - 1999. - No. 9. (in Russian).
- Karlik S.J., Eichhorn G.L., Crapper D.R. Molecular interactions of aluminum with DNA. Neurotoxicology. 1980a; 1: Pp. 83–88.
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