COMPARATIVE TOXICITY OF CERTAIN ALCOHOLS AND ALCOHOL-BASED SKIN ANTISEPTICS

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Abstract

The cytotoxic action of skin antiseptics based on ethyl, propyl and isopropyl alcohols were investigated into the culture of human embryonic fibroblast cells using MTT-test and xCELLigence system for real-time analysis into the bull spermatozoa with registering toxicity index. The dependence of the cytotoxicity degree on the chemical composition of a preparation was established. The investigation of antiseptics skin-resorptive action mechanisms in weanling rats has shown that prepubertal females are more sensitive to the effect of alcohols compared to males. The use of skin antiseptics based on ethyl and isopropyl alcohols is recommended for hygienic treatment of children’s hands.

About the authors

M. V. Bidevkina

Scientific Research Disinfectology Institute, Rospotrebnadzor

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

O. V. Baklanova

D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

T. Z. Rysina

Scientific Research Disinfectology Institute, Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

I. A. Suetina

D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

O. A. Lopatina

D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

T. N. Potapova

Scientific Research Disinfectology Institute, Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

M. V. Mezentseva

D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

A. V. Limantsev

Scientific Research Disinfectology Institute, Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

L. I. Russu

D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

Zh. P. Alekseeva

Scientific Research Disinfectology Institute, Rospotrebnadzor

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2016 Bidevkina M.V., Baklanova O.V., Rysina T.Z., Suetina I.A., Lopatina O.A., Potapova T.N., Mezentseva M.V., Limantsev A.V., Russu L.I., Alekseeva Z.P.



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