Synthesis and effect of substituted pyrido[2,3-d]pyrimidine-2,4-diones on In Vitro tumor dna methylation

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Resumo

Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-halophenyl)-5,6-dihydro1 H -pyrido[2,3- d ]pyrimidine-2,4-diones and 1,3-dimethyl-7-aryl-6-phenyl-(4-halophenyl)-1 H -pyrido[2,3- d ] pyrimidine-2,4-diones. The effect of the synthesized compounds in vitro tumor DNA methylation was studied.

Sobre autores

A. Isakhanyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru

N. Hakobyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Z. Hovasyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

L. Nersesyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Aharonyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

I. Danielyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

H. Panosyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Harutyunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Bibliografia

  1. Мещерякова С.А. Дисс. … докт. фарм. наук. Уфа, 2015.
  2. Fares M., Abou-Seri S.M., Abdel-Aziz H.A., Abbas S.E., Youssef M.M., Eladwy R.A. // Eur. J. Med. Chem. 2014. Vol. 83. P. 155. doi: 10.1016/j.ejmech.2014.06.027
  3. Abadi A.H., Hany M.S., Elsharif S.A., Eissa A.A., Gary B.D., Tinsley H.N., Piazza G.A. // Chem. Pharm. Bull. 2013. Vol. 61. N 4. P. 405. doi: 10.1248/cpb.c12-00993
  4. Vanyushin B.F. // JSM Genet. Genomics. 2016. Vol. 3. N 1. P. 1010.
  5. Azad N., Zahnow C.A., Rudin C.M., Baylin S.B. // Nat. Rev. Clin. Oncol. 2013. Vol. 10. N 5. P 256. doi: 10.1038/nrclinonc.2013.42
  6. Геворгян Г.А., Авакян А.П., Агабабян А.Г., Акопян Н.З., Маркарян Т.А., Паносян Г.А. // Хим. ж. Армении. 2013. T. 66. № 4. С. 597.
  7. Baylin S.B., Herman J.G. // Trends Genetics. 2000. Vol. 16. N 4. P. 168.
  8. Howell P.M., Jr., Liu Z., Khong H.T. // Pharmaceuticals. 2010. Vol. 3. N 7. P. 2022. doi: 10.3390/ph3072022
  9. Геворгян Г.А., Авакян А.П., Гаспарян Н.К., Паносян Г.А. // ЖОрХ. 2009. Т. 45. С. 1854
  10. Gevorgyan G.A., Avakyan A.P., Gasparyan N.K., Panosyan G.A. // Russ. J. Org. Chem. 2009. Vol. 45. P. 1853. doi: 10.1134/S1070428009120173
  11. Vanyushin B.F., Masin A.L., Vasiliev V.K., Belozersky A.N. // Biochim. Biophys. Acta. 1973. Vol. 299. N 3. P. 397. doi: 10.1016/0005-2787(73)90264-5

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