Synthesis and Antioxidant Activity of Alkyl N-(9H-Thioxanthen-9-yl)(cyclo)alkylhydrazides

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Аннотация

A series of new alkyl N-(9H-thioxanthen-9-yl)(cyclo)alkylhydrazides was obtained for the first time by the reaction of (cyclo)alkylhydrazides, 9H-thioxanthen-9-ol and pyridinium perchlorate in a pyridine medium. The antioxidant activity of alkyl N-(9H-thioxanthen-9-yl)(cyclo)alkylhydrazides was studied. The greatest antioxidant effect was revealed in linear and cyclic N-(9H-thioxanthen-9-yl)(cyclo)alkylhydrazides, the values of which are in the range of 0.72–0.88 from ascorbic acid. The presence of a branched radical in N-(9H-thioxanthen-9-yl)alkylhydrazides significantly reduces the antioxidant properties.

Толық мәтін

Рұқсат жабық

Авторлар туралы

V. Gorokhov

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0003-3829-5038
Ресей, Perm, 614013

S. Zabolotnykh

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0001-8307-0386
Ресей, Perm, 614013

A. Kharitonova

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0002-4791-5799
Ресей, Perm, 614013

L. Chekanova

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0003-1792-6945
Ресей, Perm, 614013

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Әрекет
1. JATS XML
Жүктеу
2. Fig. 1. General view of the 4d compound molecule according to X-ray diffraction data, represented by thermal ellipsoids with a 30% probability.

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Метадеректер
3. 2. Values of antioxidant activity of alkyl-N-(9H-thioxanthene-9-yl)(cyclo)alkylhydrazides 4a–K.

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4. 3. Spectra of the FRAP solution before and after the addition of ascorbic acid (AC) or compound 4j (l = 10 mm, background – water, CA = 2.5·10-3 mol/l, c4j = 10-3 mol/l).

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5. Scheme 1.

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