Synthesis of 2-alkyl-1,2,4-triazolo[3,4-a]isoquinolin-2-ium bromides and hexafluorophosphates

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Abstract

Alkylation of 1,2,4-triazolo[3,4-a]isoquinolines with 1-bromoalkanes was carried out under microwave synthesis conditions; the resulting 2-alkyl-1,2,4-triazolo[3,4-a]isoquinolin-2-ium bromides were converted into hexafluorophosphates and characterized by high-resolution mass spectrometry, 1H, 13C NMR spectroscopy and X-ray diffraction analysis.

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About the authors

L. S. Ermakova

Institute of Technical Chemistry, Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences

Email: glusha55@gmail.com
ORCID iD: 0009-0008-1397-6631
Russian Federation, 614068, Perm

N. O. Leont’ev

Perm State National Research University

Email: glusha55@gmail.com
ORCID iD: 0009-0000-9777-0658
Russian Federation, 614099, Perm

M. S. Denisov

Institute of Technical Chemistry, Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences

Email: glusha55@gmail.com
ORCID iD: 0000-0002-8817-0543
Russian Federation, 614068, Perm

I. А. Borisova

Perm State National Research University

Email: glusha55@gmail.com
ORCID iD: 0000-0002-2261-8122
Russian Federation, 614099, Perm

М. V. Dmitriev

Perm State National Research University

Email: glusha55@gmail.com
ORCID iD: 0000-0002-0731-3400
Russian Federation, 614099, Perm

V. A. Glushkov

Institute of Technical Chemistry, Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences; Perm State National Research University

Author for correspondence.
Email: glusha55@gmail.com
ORCID iD: 0000-0001-6493-7351
Russian Federation, 614068, Perm; 614099, Perm

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Supplementary files

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2. Scheme 1.

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3. Fig. 1. General view of the bromide molecule 2b according to X-ray diffraction data, represented by thermal ellipsoids of 30% probability.

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4. Fig. 2. General view of the bromide molecule 4a according to X-ray diffraction data, represented by thermal ellipsoids of 30% probability.

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