The effectiveness of respiratory support in the early period of intoxication of rabbits with products of thermal degradation of fluoroplast-4

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Inhalation intoxication with acylating pulmonotoxicants (phosgene, perfluoroisobutylene) leads to the formation of toxic pulmonary edema, pharmacological approaches to the treatment of which are ineffective. Respiratory therapy is successfully used to treat non-toxic pulmonary edema. Data on the effectiveness of respiratory support in toxic pulmonary edema are limited. The aim of the study was to experimentally evaluate the effectiveness of protective ventilation with positive end-expiratory pressure in the early period of intoxication by products of thermal degradation of fluoroplast-4. Early initiation of protective ventilation with positive end-expiratory pressure proved to be effective for the correction of toxic pulmonary edema in rabbits in the early period of intoxication by products of thermal degradation of fluoroplast-4 with pulmonotoxic effects. Respiratory support may be an effective approach for the treatment of toxic pulmonary edema caused by intoxication with acylating pulmonotoxicants.

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Sobre autores

P. Tolkach

Kirov Military Medical Academy

Autor responsável pela correspondência
Email: pgtolkach@gmail.com
Rússia, St. Petersburg

D. Yaroshenko

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Rússia, St. Petersburg

A. Khovpachev

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Rússia, St. Petersburg

D. Sizova

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Rússia, St. Petersburg

Yu. Ilatovskaya

Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov

Email: pgtolkach@gmail.com
Rússia, St. Petersburg

G. Gracheva

Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov; St. Petersburg State University of veterinary medicine

Email: pgtolkach@gmail.com
Rússia, St. Petersburg; St. Petersburg

V. Basharin

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Rússia, St. Petersburg

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2. Fig. 1. (a) — blood hemoglobin saturation; (b) — partial pressure of carbon dioxide in exhaled air (PeCO2) of rabbits, determined during respiratory support, Me.

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3. Fig. 2. Pulmonary coefficient of rabbits 6 hours after exposure against the background of protective mechanical ventilation with PEEP, relative units, Me [Q1; Q2]. Notes: in each group n = 3; * — differences are significant, compared with the control group, p < 0.05; # — differences are significant, compared with the intoxication group, p < 0.05.

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