Opsins and their testing in heterological expression systems
- Авторлар: Chiligina Y.A.1
-
Мекемелер:
- Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- Шығарылым: Том 144, № 6 (2024)
- Беттер: 635-649
- Бөлім: Articles
- ##submission.dateSubmitted##: 30.05.2025
- ##submission.datePublished##: 15.12.2024
- URL: https://rjpbr.com/0042-1324/article/view/681430
- DOI: https://doi.org/10.31857/S0042132424060032
- EDN: https://elibrary.ru/NRVIEQ
- ID: 681430
Дәйексөз келтіру
Толық мәтін
Аннотация
The study of photosensitive proteins as optogenetic tools for the therapeutic restoration of visual functions in heterologous expression systems is a necessary step prior to their optogenetic prosthetization in the retina. The review considers the features of opsins and factors affecting their activity in model cell systems. Particular attention is paid to G-protein-coupled opsins as promising tools for recreating the signaling cascade mechanisms of in retinal ON-bipolar cells. Based on the analysis of light-controlled responses of natural and chemical light-sensitive proteins in tests, the selection of the best, promising in gene therapy is made.
Толық мәтін

Авторлар туралы
Y. Chiligina
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: julchil@mail.ru
Ресей, St. Petersburg
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