Strategic Tasks and Prospects for the Development of the Resource Base of Healthcare and Health Saving through the Prism of Personalized and Precision Medicine

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Abstract

Current research indicates the importance of a personalized approach to health care, including quality preclinical laboratory diagnostics, preventive and prophylactic nutrition and the construction of individualized nutritional protocols, and well-being of the microenvironment as a whole. This article analyzes existing methods and technologies in the fields of personalized nutritional, medicine, precision fudomics and bioinformatics and their contribution to healthcare, reviewing key aspects of these fields and suggesting directions for further research and implementation.

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About the authors

S. V. Suchkov

Institute of Biotechnology and Global Health; Russian University of Medicine; New York Academy of Sciences

Author for correspondence.
Email: ssuchkov57@gmail.com

Department of Clinical Allergology and Immunology

Russian Federation, Moscow; Moscow; New York, USA

H. Abe

Abe Cancer Clinic

Email: ssuchkov57@gmail.com
Japan, Tokyo

A. I. Berezhnoy

Institute of Biotechnology and Global Health

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

S. Murphy

Harvard Medical School

Email: ssuchkov57@gmail.com
United States, Boston, MA

V. S. Polyakova

Institute of Biotechnology and Global Health

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

M. V. Vasiliev

Institute of Biotechnology and Global Health

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

A. P. Ovchinnikov

Institute of Biotechnology and Global Health

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

D. Smith

Mayo Clinic

Email: ssuchkov57@gmail.com
United States, Rochester, MN

V. M. Zemskov

Vishnevsky National Medical Research Center of Surgery

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

A. S. Revishvili

Vishnevsky National Medical Research Center of Surgery

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

V. S. Demidova

Vishnevsky National Medical Research Center of Surgery

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

D. Scherman

Centre National de la Recherche Scientifique, Unité de Pharmacologie Chimique et Génétique d'Imagerie

Email: ssuchkov57@gmail.com
France, Paris

A. P. Glinushkin

Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: ssuchkov57@gmail.com
Russian Federation, Moscow

A. M. Zemskov

Burdenko Voronezh State Medical University

Email: ssuchkov57@gmail.com
Russian Federation, Voronezh

P. Barach

Wayne State University, School of Medicine

Email: ssuchkov57@gmail.com
United States, Detroit, MI

A. N. Suvorov

Institute of Experimental Medicine, Russian Academy of Sciences

Email: ssuchkov57@gmail.com
Russian Federation, St. Petersburg

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2. Fig. 1. Dynamics of chronic diseases.

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3. Fig. 2. The general structure of the consequences of diseases (data for Europe). The proportion of disability (light gray) and the proportion of mortality (dark gray).

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4. Fig. 3. Basic determinants of individual health.

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5. Fig. 4. Personalized and precision medicine.

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6. Fig. 5. Strategic technologies and tools of the BPM.

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7. Fig. 6. A group of health-influencing factors that must be taken into account in personal health management programs.

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8. Fig. 7. The influence of genetic, phenotypic and exposomal factors on the health of an individual.

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9. Fig. 8. Development and progression of chronic disease: the main periods (stages) of development and progression of pathology through the prism of PPM.

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10. Fig. 9. Types, families and categories of biomarkers.

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11. Fig. 10. Circulating tumor (transformed) cells.

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12. 11. Systems biology is an integrative science and a source of transdisciplinary approaches to the development of technological methods and techniques in the field of PM.

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13. Figure 12. Translational medicine.

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14. Fig. 13. Informatization of medicine through the prism of bioinformatics.

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15. Fig. 14. The scheme of application of multiomic technologies in the creation of new generation medicines.

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