Distant ischemic preconditioning and the regulation of vascular tone in miners with vibration disease combined with ischemic heart disease

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Introduction. There is a adverse trend in increasing prevalence of cardiovascular diseases among miners, especially those with an established diagnosis of occupational disease, which in combination aggravates the risk of permanent loss of working capacity. The similarity of some pathogenetic mechanisms of development of vibration disease (VD) and ischemic heart disease (IHD) determines the possibility of their early general prevention.Objective of the investigation was to study the effect of distant ischemic preconditioning on the regulation of microcirculation in patients with VD associated with IHD.Material and methods. The study involved twenty two male 42 to 54 years miners with a proven diagnosis of VD in combination with IHD; work experience was more than 15 years. The features of autonomic regulation were assessed using spectral analysis of heart rate variability, microcirculation indices and tissue blood perfusion were detected by laser Doppler flowmetry before and after a course of distant ischemic preconditioning according to the elaborated technique. Results. In the examined miners with VD in combination with IHD, a decrease in heart rate variability was initially detected, indicating a violation of the autonomic regulation of the heart and being an unfavourable marker of the risk of sudden cardiac death. After a course of ischemic preconditioning, an increase in variability was observed, statistically significant in the low and very low frequency ranges of the spectrum. A tendency towards an increase in the microcirculation index was also revealed, which reflects an improvement in tissue perfusion with blood.Limitations. The study is limited to the number of long-term labour experience miners with a proven diagnosis of VD in combination with IHD, without heart rhythm disturbances and implantable devices affecting the heart rhythm, and those who underwent an in-depth medical examination in the Clinic of the Research Institute for Complex Problems of Hygiene and Occupational Diseases.Conclusion. The results obtained give grounds to continue studying the role of distant ischemic preconditioning as a method of correcting autonomic disorders in vibration disease in patients with ischemic heart disease.Compliance with ethical standards. The study was approved by the local Ethics Committee of the Federal State Budgetary Scientific Institution “Research Institute for Complex Problems of Hygiene and Occupational Diseases” (protocol of meeting No. 3 §3 dated November 17, 2022). All participants gave informed voluntary written consent to participate in the study.Contribution: Martynov I.D. – collection and processing of material, writing a text; Panev N.I. – the concept and design of the study, editing; Sharagasheva T.A. – data collection and processing, writing the text; Filimonov E.S. – data processing, editing; Yamshchikova A.V. – editing. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.Conflict of interest. The authors declare no conflict of interest.Acknowledgement. The study had no sponsorship.Received: January 22, 2025 / Revised: February 18, 2025 / Accepted: March 26, 2025 / Published: April 30, 2025

About the authors

Ilya D. Martynov

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: mart-nov@yandex.ru

Nikolay I. Panev

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: panevni@gmail.com

Tatyana A. Sharagasheva

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: tankuzya@mail.ru

Egor S. Filimonov

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: 171fes@gmail.com

Anastasia V. Yamshchikova

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: anastyam@bk.ru

References

  1. Бабанов С.А., Азовскова Т.А., Вакурова Н.В., Бараева Р.А. О современных аспектах классификации вибрационной болезни. Терапевт. 2019; (4): 7–21. https://elibrary.ru/zcqfgh
  2. Сазыкина Д.П., Дудина Е.А., Шокина С.В., Горячева О.А. Современные аспекты диагностики и лечения вибрационной болезни. Актуальные научные исследования в современном мире. 2020; (2–2): 32–5. https://elibrary.ru/bhujgp
  3. Ямщикова А.В., Флейшман А.Н., Мартынов И.Д. Оценка вегетативных нарушений у шахтёров с вибрационной болезнью. Гигиена и санитария. 2023; 102(7): 664–9. https://doi.org/10.47470/0016-9900-2023-102-7-664-669 https://elibrary.ru/qczrmo
  4. Власова Е.М., Воробьева А.А. Пародоксы в медицине труда. Медицина труда и экология человека. 2023; 63(3): 50–60. https://doi.org/10.24412/2411-3794-2023-10304 https://elibrary.ru/ucqmws
  5. Dzhambov A.M., Dimitrova D.D. Heart disease attributed to occupational noise, vibration and other co-exposure: Self-reported population-based survey among Bulgarian workers. Med. Pr. 2016; 67(4): 435–45. https://doi.org/10.13075/mp.5893.00437
  6. Шастин А.С., Газимова В.Г., Цепилова Т.М., Малых О.Л., Панов В.Г. Заболеваемость болезнями системы кровообращения населения трудоспособного возраста в Российской Федерации в 2015–2019 гг. Региональные особенности. Профилактическая медицина. 2022; 25(11): 28–35. https://doi.org/10.17116/profmed20222511128 https://elibrary.ru/vhbdyj
  7. Коротенко О.Ю., Филимонов Е.С., Мартынов И.Д. Факторы риска развития сердечной недостаточности с сохранённой фракцией выброса левого желудочка у работников основных профессий угольной промышленности. Медицина труда и промышленная экология. 2023; 63(9): 611–6. https://doi.org/10.31089/1026-9428-2023-63-9-611-616 https://elibrary.ru/lwgyrk
  8. Tan W., Zhang C., Liu J., Li X., Chen Y., Miao Q. Remote ischemic preconditioning has a cardioprotective effect in children in the early postoperative phase: a meta-analysis of randomized controlled trials. Pediatr. Cardiol. 2018; 39(3): 617–26. https://doi.org/10.1007/s00246-017-1802-7 https://elibrary.ru/puwfjv
  9. Billah M., Ridiandries A., Allahwala U.K., Mudaliar H., Dona A., Hunyor S., et al. Remote ischemic preconditioning induces cardioprotective autophagy and signals through the il-6-dependent JAK-STAT pathway. Int. J. Mol. Sci. 2020; 21(5): 1692. https://doi.org/10.3390/ijms21051692 https://elibrary.ru/aojrmy
  10. Ямщикова А.В., Мартынов И.Д., Флейшман А.Н., Гидаятова М.О. Применение ишемического прекондиционирования в реабилитации шахтёров с вибрационной болезнью. Гигиена и санитария. 2021; 100(7): 700–3. https://doi.org/10.47470/0016-9900-2021-100-7-700-703 https://elibrary.ru/hcarii
  11. Коротенко О.Ю., Панев Н.И., Корчагина Ю.С., Панев Р.Н., Данилов И.П. Формирование патологии внутренних органов у шахтеров с вибрационной болезнью. Медицина труда и промышленная экология. 2020; 60(6): 399–403. https://doi.org/10.31089/1026-9428-2020-60-6-399-403 https://elibrary.ru/tuzqfq
  12. Мелентьев А.В., Серебряков П.В., Жеглова А.В. Влияние шума и вибрации на нервную регуляцию сердца. Медицина труда и промышленная экология. 2018; 58(9): 19−23. https://doi.org/10.31089/1026-9428-2018-9-19-23 https://elibrary.ru/yjgust
  13. Rytter N., Carter H., Piil P., Sørensen H., Ehlers T., Holmegaard F., et al. Ischemic preconditioning improves microvascular endothelial function in remote vasculature by enhanced prostacyclin production. J. Am. Heart Assoc. 2020; 9(15): e016017. https://doi.org/10.1161/JAHA.120.016017 https://elibrary.ru/xfdurd
  14. Аргунова Ю.А., Короткевич А.А., Помешкина С.А., Коков А.Н., Иноземцева А.А., Барбараш О.Л. Эффективность физических тренировок как метода кардиопротекции у пациентов перед коронарным шунтированием. Российский кардиологический журнал. 2018; 23(6): 159–65. https://doi.org/10.15829/1560-4071-2018-6-159-165 https://elibrary.ru/xsltvb
  15. Маслов Л.Н., Цибульников С.Ю., Прокудина Е.С., Бушов Ю.В., Нам И.Ф., Нестеров Е.А. и др. Роль симпатоадреналовой системы в ишемическом прекондиционировании сердца. Российский физиологический журнал им. И.М. Сеченова. 2018; 104(5): 521–35. https://elibrary.ru/xnsmmx

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2025



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.