The impact of drinking water of various quality on intact and irradiated mice
- 作者: Ivanov A.A.1,2, Andrianova I.E.1, Mal'tsev V.N.1, Shalnova G.A.1, Stavrakova N.M.1, Bulinina T.M.1,2, Dorozhkina O.V.1,2, Karaulova T.A.1, Gordeev A.V.1, Bushmanov A.Y.1
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隶属关系:
- A.I. Burnazyan Federal Medical Biophysical Centre
- Institute of Biomedical Problems of the Russian Academy of Sciences
- 期: 卷 96, 编号 9 (2017)
- 页面: 854-860
- 栏目: ENVIRONMENTAL HYGIENE
- ##submission.datePublished##: 21.10.2020
- URL: https://rjpbr.com/0016-9900/article/view/640758
- DOI: https://doi.org/10.47470/0016-9900-2017-96-9-854-860
- ID: 640758
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In experiments on intact mice provided by continuous access to drinking water with reduced oxidation-reduction potential (ORP) only for 30-49 days there are revealed following signs of a modification of the vital status: a slowdown in body weight gain, a decrease in behavioral activity, a decrease in the thymus and spleen mass, signs of a change in intestinal microflora composition, in comparison with the original tap water and distilled water. Reduction of ORP was achieved by distillation of water, and also by electrochemical treatment at the "Ideal" plant. In addition, water samples were used in the experiment with the addition of antioxidants: ascorbic acid and melanin, which also reduced the ORP. At X-ray irradiation in a non-lethal dose of 1.5 Gy, 24 hours after exposure to radiation, there were no statistically significant differences in the damaging effect of radiation in animals that drank water of different quality. At the same time, with an irradiation dose of 5 Gy, an acceleration in the recovery of hematological indices and behavioral activity in the use of water with reduced ORP was noted. The intake of these water samples after irradiation contributed to a statistically significant increase in the number of endogenous hematopoiesis colonies in the spleen as compared to the use of tap water.
作者简介
Aleksandr Ivanov
A.I. Burnazyan Federal Medical Biophysical Centre; Institute of Biomedical Problems of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: a1931192@mail.ru
MD, PhD, head of the Laboratory of Radiation Immunology and Experimental Therapy of Radiation Defeats of the A.I. Burnazyan Federal Medical and Biophysical Center of FMBA of Russia, Moscow, 123182, Russian Federation.
e-mail: a1931192@mail.ru
俄罗斯联邦I. Andrianova
A.I. Burnazyan Federal Medical Biophysical Centre
Email: noemail@neicon.ru
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V. Mal'tsev
A.I. Burnazyan Federal Medical Biophysical Centre
Email: noemail@neicon.ru
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G. Shalnova
A.I. Burnazyan Federal Medical Biophysical Centre
Email: noemail@neicon.ru
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N. Stavrakova
A.I. Burnazyan Federal Medical Biophysical Centre
Email: noemail@neicon.ru
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T. Bulinina
A.I. Burnazyan Federal Medical Biophysical Centre; Institute of Biomedical Problems of the Russian Academy of Sciences
Email: noemail@neicon.ru
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O. Dorozhkina
A.I. Burnazyan Federal Medical Biophysical Centre; Institute of Biomedical Problems of the Russian Academy of Sciences
Email: noemail@neicon.ru
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T. Karaulova
A.I. Burnazyan Federal Medical Biophysical Centre
Email: noemail@neicon.ru
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A. Gordeev
A.I. Burnazyan Federal Medical Biophysical Centre
Email: noemail@neicon.ru
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A. Bushmanov
A.I. Burnazyan Federal Medical Biophysical Centre
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参考
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- Ivanov A.A., Andrianova I.E., Bulynina T.M., Dorozhkina O.V., Mal'tsev V.N., Stavrakova N.M., et al. The pharmacological effects of melanin in the irradiated mice. Meditsinskaya radiologiya i radiatsionnaya bezopasnost'. 2015; 60(5): 5–11. (in Russian)
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