A systematic analysis of relationships between biochemical indices in persons exposed to mercury
- 作者: Kudaeva I.V.1, Masnavieva L.B.1, Naumova O.V.1, Dyakovich O.A.1
-
隶属关系:
- East-Siberian Institute of Medical and Ecological Research
- 期: 卷 97, 编号 10 (2018)
- 页面: 990-994
- 栏目: METHODS OF HYGIENIC AND EXPERIMENTAL INVESTIGATIONS
- ##submission.datePublished##: 22.10.2020
- URL: https://rjpbr.com/0016-9900/article/view/640521
- DOI: https://doi.org/10.47470/0016-9900-2018-97-10-990-994
- ID: 640521
如何引用文章
全文:
详细
Introduction. Changes in biochemical indices characterizing the state of lipid peroxidation processes – antioxidant protection and lipid metabolism are observed during the occupational contact with mercury. These changes play a certain pathogenic role in the formation of disorders in the nervous system during mercury intoxication. In this regard, the aim was to study the relationship between biochemical indices at different stages of the development of mercury intoxication to justify approaches to therapeutic and preventive measures.
Material and methods. A prospective cohort examination of persons exposed to the mercury vapor with signs of disorders in the nervous system, patients with chronic mercury intoxication and working in contact with mercury more than 5 years without signs of pathology was carried out. To study the relationship of features between biochemical indices, the sum of the square of correlation relations between the indices was calculated, the ranks of the influence of the system components on other factors and their dependencies were determined.
Results. The decline in the level of nitric oxide metabolites was found to be one of the initial, long-term persisting in the pathogenesis of biochemical abnormalities, formed due to the contact with mercury. The development of the nervous system pathology under the mercury influence is accompanied by a change in the ratio of pro- and anti- oxidative processes, lipid metabolism disorders have an independent pathogenic significance. The long-term period of the chronic mercury intoxication is characterized by the formation of complex relationships in the biochemical system, the presence of several closed subsystems, which include nitrogen oxide metabolites.
Conclusion. Given peculiarities of systemic interactions between biochemical indices, determining the role of certain factors in the overall system, as well as the presence/absence and composition of subsystems, pathogenic approaches to the correction of metabolic disorders at various stages of the mercury intoxication formation should be different.
作者简介
Irina Kudaeva
East-Siberian Institute of Medical and Ecological Research
编辑信件的主要联系方式.
Email: kudaeva_irina@mail.ru
ORCID iD: 0000-0002-5608-0818
MD, Ph.D., DSci, associate professor, Deputy Director for scientific work, of the East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.
e-mail: kudaeva_irina@mail.ru
俄罗斯联邦L. Masnavieva
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-1400-6345
俄罗斯联邦
O. Naumova
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-5353-2268
俄罗斯联邦
O. Dyakovich
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-4903-1401
俄罗斯联邦
参考
- Sudakov K.V., Umryuhin P.E. System basis of emotional stress. M.: GEHOTAR-Media; 2010 (in Russian).
- Shang D., Li C., Yao Q., Yang H., Xu Y., Han J., et al. Prioritizing candidate disease metabolites based on global functional relationships between metabolites in the context of metabolic pathways. PLoS One. 2014; 9(8): 104934.
- Sudakov K. V. Theory of functional systems and its application in physiology and medicine. Novosti medikobiol. nauk. Minsk, 2004; 4: 109–133. (in Russian).
- Rusalov V. Functional systems theory and the activity-specific approach in psychological taxonomies. Philos Trans R Soc Lond B Biol Sci. 2018; 373 (1744).
- Kudaeva I.V., Budarina L.A. Changes in biochemical parameters under the influence of metal mercury vapor. Acta Biomedica Scientifica. 2012; 6 (88): 24-27 (in Russian).
- Masnavieva L.B., Budarina L.A., Kudaeva I.V. Indicators of antioxidant protection and lipid peroxidation in patients with long-term neurointoxication. Acta Biomedica Scientifica. 2010; 4: 115-118 (in Russian).
- Rukavishnikov V.S., Lakhman O.L., Sosedova L.M., Shayahmetov S.F., Bodienkova G.M., Kudaeva I.V. I dr. Professional neurointoxications: regularities and mechanisms of formation. Medicina truda I promyshlennaya ehkologiya. 2014; 4: 1-6 (in Russian).
- Kudaeva I.V. The role of oxidative stress in the pathogenesis of occupational diseases caused by exposure to toxic substances. Vestnik novyh medicinskih tekhnologij. 2009; 16(51): 253-254 (in Russian).
- Odewabi A.O., Ekor M. Levels of heavy and essential trace metals and their correlation with antioxidant and health status in individuals occupationally exposed to municipal solid wastes. Toxicol Ind Health. 2017; 33(5): 431-442.
- Liguori I., Russo G., Curcio F., Bulli G., Aran L., Della-Morte D., et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13: 757-772.
- Medina-Navarro R., Corona-Candelas I., Barajas-González S., Díaz-Flores M., Durán-Reyes G. Albumin antioxidant response to stress in diabetic nephropathy progression. Medina- PLoS One. 2014; 4: 9(9).
- Mensink R.P., Zock P.L., Kester A.D., Katan M.B. Am J. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Clin. Nutr. 2003; 77(5): 1146-55.
- Pristrom M.S., Semenenkov I. I., Olihver YU.A. Omega-3 polyunsaturated fatty acids: mechanisms of action, evidence of benefit and new prospects for use in clinical practice. Mezhdunarodnye obzory: klinicheskaya praktika i zdorov’e. 2017. 75-85 p. (in Russian).
- De Mattos A.M., da Costa J.A.C., Jordão Júnior A.A., Chiarello PG.J. Omega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients. Ren. Nutr. 2017; 27(5): 333-339.
- Diagnosis and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis. Rossijskie rekomendacii. V peresmotr. Moscow. 2012. 50 p.
- Alkahtani S., Elkilany A., Alhariri M. Association between sedentary and physical activity patterns and risk factors of metabolic syndrome in Saudi men: A cross-sectional study. BMC Public Health. 2015; 12(15): 1234.
- Volotovskaya A.V. Antioxidant effect and therapeutic efficacy of laser irradiation of blood in patients with coronary heart disease. Voprosy kurortologii, fizioterapii i lechebnoj fizicheskoj kul’tury. 2003; 3: 22–25. (in Russian).
- Doncov A.V. Low-intensity laser radiation in the treatment of patients with coronary heart disease with metabolic syndrome (review of literature). Vestnik novyh medicinskih tekhnologij. 2012; (19), 4: 144-147. (in Russian).
- Aldini G.1., Altomare A., Baron G., Vistoli G., Carini M., Borsani L. et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018; 9: 1-12.
- Seifar F., Khalili M., Khaledyan H., Amiri Moghadam S., Izadi A., Azimi A. et al. α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review. Nutr Neurosci. 2017; 29: 1-11.
- Saleh H.M., El-Sayed Y.S., Naser S.M., Eltahawy A.S., Onoda A., Umezawa M. Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain. Environ Sci Pollut Res Int. 2017; 24(31): 24593-24601.
- Tibullo D., Li Volti G., Giallongo C., Grasso S., Tomassoni D., Anfuso C.D., et al. Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential. Inflamm Res. 2017; 66(11): 947-959.
- Teixeira T.M., da Costa D.C., Resende A.C., Soulage C.O., Bezerra F.F., Daleprane J.B. Activation of Nrf2-antioxidant signaling by 1,25-dihydroxycholecalciferol prevents leptin-Induced oxidative stress and inflammation in human endothelial cells. J. Nutr. 2017; 147(4): 506-513.
- Mirończuk-Chodakowska I., Witkowska A.M., Zujko M.E. Endogenous non-enzymatic antioxidants in the human body. Adv Med Sci. 2018; 63(1): 68-78.
- Boyarskaya L.A., Turchaninov D.V., Efremenko E.S., Bogdashin I.V., Vil’ms E.A., YUnackaya T.A. The study of glutathione and its metabolism enzymes under the influence of enriched dairy products for preventive purposes in conditions of oxidative stress caused by excessive physical exertion. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2015; 8: 2-56. (in Russian).
- Sun Y., Li Y., Rao J., Liu Z., Chen Q. J. Effects of inorganic mercury exposure on histological structure, antioxidant status and immune response of immune organs in yellow catfish (Pelteobagrus fulvidraco). Appl Toxicol. 2018; 38(6): 843-854.
- Fujimura M., Usuki F. In situ different antioxidative systems contribute to the site-specific methylmercury neurotoxicity in mice. Toxicology. 2017; 1(392): 55-63.
- Leão L.K.R., Herculano A.M., Maximino C., Brasil Costa A., Gouveia A. Jr., Batista E.O. et al. Mauritiaflexuosa L. protects against deficits in memory acquisition and oxidative stress in rat hippocampus induced by methylmercury exposure. Nutr. Neurosci. 2017; 20(5): 297-304.
- Park K., Seo E.J. Toenail mercury and dyslipidemia: Interaction with selenium. Trace Elem Med Biol. 2017; 39: 43-49.
补充文件
