Change of some biochemical indices depending on exposure load in staff workers in contact with vinyl chloride

Cover Page

Cite item

Full Text

Abstract

Introduction. The paper presents the results of a survey of 42 experienced workers of a chemical enterprise exposed to vinyl chloride (VC). The purpose of the study is to establish the characteristics of changes in some biochemical indices in workers exposed to vinyl chloride, depending on the exposure load. 

Material and methods. A neurological, general therapeutic, ultrasound examination, biochemical studies with the determination of lipid profile, lipid peroxidation, and antioxidant protection, neurotransmitters was executed. The toxic exposure load (TEL) for the entire period of internship has been determined. Non-parametric methods of statistical analysis with the determination of the Mann-Whitney U-test were used. 

Results. Clinical manifestations of employees working in contact with VC included asthenic disorder with cognitive impairment and autonomic dysfunction syndrome, arterial hypertension, and gastrointestinal diseases. The prevalence of cognitive impairments and hypertension has been established to increases with an extremely high level of exposure load. In individuals with an extremely high level of exposure, higher concentrations of LDL cholesterol, atherogenic index (AI) and serotonin levels, and a decrease in the level of ceruloplasmin were noted. An ultrasound examination of the liver revealed an increase in the anteroposterior size of the right lobe in the group of experienced workers who were in contact with VC, compared with the control (p = 0.03). 

Discussion. Among the indices of lipid metabolism, pro-atherogenic cholesterol fractions are a more sensitive marker, reflecting the degree of exposure to VC. A decrease in the concentration of ceruloplasmin is probably associated with a weakening of the antioxidant defense mechanisms with an increase in the level of TEL. Increased serotonin levels in individuals with extremely high levels of TEL, confirms the prevalence of cognitive impairment in this group. In the group of individuals with extremely high levels of TEL, a statistically significant increase in LDL cholesterol, IA, a decrease in ceruloplasmin concentration, an increase in serotonin serum levels due to impaired metabolic and protective functions of the liver as a result of prolonged contact with VC were noted.

About the authors

Elena V. Katamanova

East-Siberian Institute of Medical and Ecological Research

Author for correspondence.
Email: katamanova_e_v@mail.ru
ORCID iD: 0000-0002-9072-2781

MD, Ph.D., Dsci., associate professor, Chief Physician of the clinic of East-Siberian Institute of Medical and Ecological Researches, Angarsk, 665827, Russian Federation.

e-mail: katamanova_e_v@mail.ru

Russian Federation

I. M. Eshchina

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0003-3229-4560
Russian Federation

I. V. Kudaeva

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5608-0818
Russian Federation

L. B. Masnavieva

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1400-6345
Russian Federation

M. P. Dyakovich

East-Siberian Institute of Medical and Ecological Research; Angarsk State Technical University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5970-5326
Russian Federation

References

  1. Toxicological profile for vinyl chloride. Agency for Toxic Substances and Disease Registry U.S. Public Health Service. 2006. 328 p.
  2. Bolognesi C., Bruzzone M., Ceppi M., Kirsch-Volders M..The lymphocyte cytokinesis block micronucleus test in human populations occupationally exposed to vinyl chloride: A systematic review and meta-analysis. Mutat Res. 2017; 774: 1-11.
  3. Meshchakova N.M., Sosedova L.M., SHayahmetov S.F., Lemeshevskaya E.P., Kapustina E.A., D’yakovich M.P. et all. Toksiko-gigienicheskie aspekty vliyaniya uslovij truda na zdorov’e rabotayushchih v proizvodstve vinilhlorida i polivinilhlorida. Irkutsk; 2014. (in Russian).
  4. Shayahmetov S.F., D’yakovich M.P., Meshchakova N.M. Ocenka professional’nogo riska narushenij zdorov’ya rabotnikov predpriyatij himicheskoj promyshlennosti. Medicina truda i promyshlennaya ehkologiya. 2008; 8: 27-33. (in Russian).
  5. Kudaeva I.V. Rol’ oksidativnogo stressa v patogeneze professional’nyh zabolevanij, voznikshih ot vozdejstviya toksicheskih veshchestv. Vestnik novyh medicinskih tekhnologij. 2009; 1(16): 253-254. (in Russian).
  6. Anders L.C., Lang A.L., Anwar-Mohamed A., Douglas A.N., Bushau A.M., Falkner K.C., et al.Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice. Toxicol Sci. 2016; 151(2): 312-23.
  7. Guardiola J.J., Beier J.I., Falkner K.C., Wheeler B., McClain C.J., Cave M. Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome. Toxicol Appl Pharmacol. 2016;313:47-56.
  8. Rukavishnikov V.S., Lahman O.L., Sosedova L.M., SHayahmetov S.F., Bodienkova G.M., Kudaeva I.V. et all. Professional’nye nejrointoksikacii: zakonomernosti i mekhanizmy formirovaniya. Medicina truda i promyshlennaya ehkologiya. 2014; 4: 1-6. (in Russian).
  9. Katamanova E.V., D’yakovich M.P., Kudaeva I.V., SHevchenko O.I., Eshchina I.M., Rukavishnikov V.S. i dr. Klinicheskie i nejrofiziologicheskie osobennosti narushenij zdorov’ya rabotnikov v zavisimosti ot ehkspozicionnoj nagruzki vinilhloridom. Gigiena i sanitariya. 2016; 12 (95): 1167-1171. (in Russian).
  10. Chen J., Costa L.G., Guizzetti M. Assessment of cholesterol homeostasis in astrocytes and neurons. Methods Mol Biol. 2011; 758: 403-14.
  11. Cacciatore S., Tenori L. Brain cholesterol homeostasis in Wilson disease. Med Hypotheses. 2013;81(6): 1127-9.
  12. Saeed A.A., Genové G., Li T., Lütjohann D., Olin M., Mast N., et al. Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain. J Biol Chem. 2014; 289(34): 23712-22.
  13. Zhang J., Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell. 2015; 6(4): 254-64.
  14. Kudaeva I.V., Demidova M.P., Budarina L.A., Masnavieva L.B. Sostoyanie organov zheludochno-kishechnogo trakta u lic, kontaktiruyushchih s hlorirovannymi uglevodorodami. Ehkologiya cheloveka. 2009; 3: 9-12. (in Russian).
  15. Kaiser J.P., Lipscomb J.C., Wesselkamper S.C..Putative mechanisms of environmental chemical-induced steatosis. Int J Toxicol. 2012; 31.(6):.551-63.
  16. Min H.K., Kapoor A., Fuchs M., Mirshahi F., Zhou H., Maher J. et all. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012; May 2; 15(5): 665-74.
  17. Niki E. Biomarkers of lipid peroxidation in clinical material. Biochim Biophys Acta. 2014; 1840 (2): 809-17.
  18. Liu Y., Zhang D., Hu J., Liu G., Chen J., Sun L. et all. Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols. J Agric Food Chem. 2015 Oct 28; 63(42): 9295-305.
  19. Giordano S., Darley-Usmar V., Zhang J. Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol. 2013; 2: 82-90.
  20. Salminen LE, Paul RH. Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review. Rev Neurosci. 2014; 25(6): 805-19.
  21. Abeti R., Uzun E., Renganathan I., Honda T., Pook MA3, Giunti P. Targeting lipid peroxidation and mitochondrial imbalance in Friedreich’s ataxia. Pharmacol Res. 2015; 99: 344-50.
  22. Arimon M., Takeda S., Post K.L., Svirsky S., Hyman B.T., Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiol Dis. 2015; 84: 109-19.
  23. Tesauro M., Mauriello A., Rovella V., Annicchiarico-Petruzzelli M., Cardillo C., Melino G., et al. Arterial ageing: from endothelial dysfunction to vascular calcification. J Intern Med. 2017; 281 (5): 471-482.
  24. Smiljić S., Nestorović V., Savić S. Modulatory role of nitric oxide in cardiac performance. Med Pregl. 2014; 67(9-10): 345-52.
  25. Usui T., Nakazawa A., Okura T., Deguchi Y., Akanuma S.I., Kubo Y., Hosoya K.I. Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4). J Neurochem. 2016; 139(3): 408-418.
  26. Orton E.C., Lacerda C.M., MacLea H.B. Signaling pathways in mitral valve degeneration. J Vet Cardiol. 2012; 14(1): 7-17.
  27. Anderson G., Berk M., Dean O., Moylan S., Maes M. Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications. CNS Drugs. 2014; 28(1): 1-10.
  28. Conti P., Shaik-Dasthagirisaheb Y.B. Mast Cell Serotonin Immunoregulatory Effects Impacting on Neuronal Function: Implications for Neurodegenerative and Psychiatric Disorders. Neurotox Res. 2015; 28(2): 147-53.
  29. Kudaeva I.V., Masnavieva L.B. Sostoyanie pokazatelej nejromediatornogo obmena u krys posle hronicheskoj intoksikacii vinilhloridom. Acta Biomedica Scientifica. 2009; 1: 244-247. (in Russian).
  30. Iglesias S., Tomiello S., Schneebeli M., Stephan K. E. Models of neuromodulation for computational psychiatry. Wiley Interdiscip Rev Cogn Sci. 2017; 8(3): 1420.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Katamanova E.V., Eshchina I.M., Kudaeva I.V., Masnavieva L.B., Dyakovich M.P.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.