Metabolic changes on the background of acute exposure to paracetamol and evaluation of the effectiveness of hepatoprotective drug
- 作者: Timasheva G.V.1, Karimov D.O.1, Repina E.F.1, Smolyankin D.A.1, Khusnutdinova N.Y.1, Mukhammadieva G.F.1, Baygildin S.S.1
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隶属关系:
- Ufa Research Institute of Occupational Health and Human Ecology
- 期: 卷 99, 编号 9 (2020)
- 页面: 1016-1021
- 栏目: EXPERIMENTAL INVESTIGATIONS
- ##submission.datePublished##: 20.10.2020
- URL: https://rjpbr.com/0016-9900/article/view/640273
- DOI: https://doi.org/10.47470/0016-9900-2020-99-9-1016-1021
- ID: 640273
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Introduction. In modern conditions, caused by the pandemic of a new type of viral infection Covid 19, the use of paracetamol, which has hepatotoxic properties in overdose, has increased. It seems relevant to study metabolic disorders in the liver in acute paracetamol intoxication and evaluate the effectiveness of the timely use of hepatoprotective drugs.
The purpose of this study is an experimental assessment of metabolic changes at the early stages of paracetamol exposure and pharmacological correction of toxic liver lesions with oxymethyluracil in comparison with known hepatoprotectors – ademetionine and Mexidol.
Material and methods. Acute intragastric administration of paracetamol to laboratory animals was performed, and the corrective effect of the drug oxymethyluracil was studied in comparison with “Heptor” and “Mexidol”. Biochemical studies of biomaterial of laboratory animals were conducted.
Results. The analysis found the use of known hepatoprotectors and oxymethyluracil after exposure to paracetamol to normalize the biochemical parameters that characterize the functional state of the liver in laboratory animals.
Conclusion. Oxymethyluracil, along with known hepatoprotectors, has a protective effect on the liver of laboratory animals under acute exposure to paracetamol comparable to, and in some cases exceeding, the corrective action of “Heptor” and “Mexidol”.
作者简介
Gulnara Timasheva
Ufa Research Institute of Occupational Health and Human Ecology
编辑信件的主要联系方式.
Email: gulnara-vt60@yandex.ru
ORCID iD: 0000-0003-2435-6936
MD, Ph.D.. Leading researcher, Department of Toxicology and Genetics with an experimental clinic of laboratory animals Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation.
e-mail: gulnara-vt60@yandex.ru
俄罗斯联邦D. Karimov
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0003-0039-6757
俄罗斯联邦
E. Repina
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0001-8798-0846
俄罗斯联邦
D. Smolyankin
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0002-7957-2399
俄罗斯联邦
N. Khusnutdinova
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5596-8180
俄罗斯联邦
G. Mukhammadieva
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0002-7456-4787
俄罗斯联邦
S. Baygildin
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0002-1856-3173
俄罗斯联邦
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