Problems of formation of the toxic hepatopathy forming in the conditions of chronic fluoride intoxication of the body

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Abstract

Introduction. Aluminium production is characterized by the accumulation of impurities of various toxic and chemical compositions in the air of working areas, the predominant among which are fluoride compounds. The accumulation of fluorides in the body causes the development of osteoarticular and associated systemic pathology. 

The aim of the study was to evaluate the hygienic and medico-biological features of toxic liver damage in the conditions of chronic fluoride intoxication of the body. 

Material and methods. The hygienic working conditions of the workers of the primary professions in aluminium production were evaluated. The analysis of hepatobiliary dysfunction based on clinical and instrumental methods was carried out in 263 subjects with fluoride intoxication and a comparison group of 116 persons. Experimental studies of the morpho-functional liver state in modelling chronic fluoride intoxication were carried out based on toxicological, biochemical, pathomorphological methods with histological analysis of tissues. The toxic properties of sodium fluoride were studied in 117 white laboratory male rats with its peroral route intake into the body.

Results. The qualitative composition of the air in the working areas in the electrolysis building was analyzed. The prevalence of pathological disorders of the biliary tract in metallurgists engaged in aluminium production was assessed. Clinical studies revealed a significant prevalence of toxic fluoride hepatopathy, fatty hepatosis, cholecystitis and other disorders in the group of patients with chronic fluoride intoxication. The harmful effect of sodium fluoride on hepatocytes, vessels of the portal tract was shown in an experiment. Hyperfunction of the reticuloendothelial system, Kupffer cell proliferation, irreversible destruction of hepatocytes, necrosis against the background of severe dystrophy, and decreased synthetic activity of the liver were determined.

Conclusion. The structure of occupational diseases in the workers engaged in the aluminium production is dominated by hepatobiliary pathology caused by toxic liver damage with fluoride confirmed by experimental data on destructive violations of its morphostructure.

Contribution:

Yadykina T.K. — the concept and design of the study, collection and processing of material, statistical processing, writing a text;

Mikhailova N.N. — the concept and design of the study, editing;

Bugaeva M.S. — collection and processing of material; Gorokhova L.G. – collection and processing of material, statistical processing;

Kislitsyna V.V. — collection and processing of material;

Danilov I.P. — collection and processing of material;

Kochergina T.V. — collection of literature data.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conclusion of the Biomedical Ethics Committee of the Research Institute for Complex Problems of Hygiene and Occupational Diseases: the clinical study was carried out with the informed consent of the subjects and complies with the ethical standards of the Bioethical Committee of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, developed in accordance with the Declaration of Helsinki by the World Association “Ethical Principles for Conducting Scientific Research with Human Participation” as amended in 2013 and “Rules of Clinical Practice in the Russian Federation” approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated June 19, 2003 Research Institute for Complex Problems of Hygiene and Occupational Diseases. The study did not infringe on the rights and did not endanger the subjects. The experimental study on rats was carried out in accordance with the international rules “Guide for the Care and Use of Laboratory Animals” (Strasbourg, 1986) and the “Rules of laboratory practice in the Russian Federation (GLP)” (approved by order of the Ministry of Health of the Russian Federation dated 19.06.2003, No. 267).

Acknowledgement. The study had no sponsorship.

Conflict of interest. The authors declare no conflict of interest.

About the authors

Tatyana K. Yadykina

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Author for correspondence.
Email: yadykina.tanya@yandex.ru
ORCID iD: 0000-0001-7008-1035

MD, PhD, leading researcher of the molecular-genetic and experimental studies laboratory of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation.

e-mail: yadykina.tanya@yandex.ru

Russian Federation

Nadezhda N. Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of the Kemerovo State University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1127-6980
Russian Federation

Maria S. Bugaeva

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0003-3692-2616
Russian Federation

Larisa G. Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of the Kemerovo State University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0545-631X
Russian Federation

Vera V. Kislitsyna

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2495-6731
Russian Federation

Igor P. Danilov

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5474-5273
Russian Federation

Tatyana V. Kochergina

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5142-2751
Russian Federation

References

  1. Onishchenko G.G., Nikolaeva N.I., Khamidulina Kh.Kh., Filin A.S., Korolev A.A., Nikitenko E.I. Problems and prospects of training specialists in preventive toxicology. Gigiena i sanitariya (Hygiene and Sanitation, Russian journal). 2019; 98(8): 799–803. https://doi.org/10.18821/0016-9900-2019-98-8-799-803 (in Russian)
  2. Sosedova L.M., Filippova T.M. The role of biosimulation in human chemical safety system. Ekologiya cheloveka. 2017; (7): 46–52. https://doi.org/10.33396/1728-0869-2017-7-46-52 (in Russian)
  3. Chebotarev A.G., Prokhorov V.A. Modern working conditions and occupational morbidity of metallurgists. Meditsina truda i promyshlennaya ekologiya. 2012; 52(6): 1–7. (in Russian)
  4. Danilov I.P., Oleshchenko A.M., Tsay L.V., Bol’shakov V.V., Surzhikov D.V., Mikhaylova N.N. Monitoring and management of the risk of occupational morbidity at an aluminum plant. Meditsina truda i promyshlennaya ekologiya. 2006; 46(6): 10–3. (in Russian)
  5. Shayakhmetov S.F., Meshchakova N.M., Lisetskaya L.G., Merinov A.V., Zhurba O.M., Alekseenko A.N., et al. Hygienic aspects of working conditions in modern aluminum production. Gigiena i sanitariya (Hygiene and Sanitation, Russian journal). 2018; 97(10): 899–904. https://doi.org/10.18821/0016-9900-2018-97-10-899-904 (in Russian)
  6. Zakharenkov V.V., Oleshchenko A.M., Danilov I.P., Surzhikov D.V., Kislitsyna V.V., Korsakova T.G. New medical technology of occupational health risks for industrial workers. Sovremennye naukoemkie tekhnologii. 2013; (9): 136–9. (in Russian)
  7. Shalina T.I., Nikolaeva L.A., Savchenkov M.F., Bykov Yu.N., Manueva R.S. Environmental pollution by fluoride compounds and their effect on children’s health. Gigiena i sanitariya (Hygiene and Sanitation, Russian journal). 2016; 95(12): 1133–7. https://doi.org/10.18821/0016-9900-2016-95-12-1133-1137 (in Russian)
  8. Roslyy O.F., Plotko E.G., Fedoruk A.A., Slyshkina T.V. Priority occupational risk factors for aluminum electrolysis. Zdorov’e naseleniya i sreda obitaniya. 2013; (9): 19–21. (in Russian)
  9. Syurin S.A. The state of health of workers in the aluminum industry in the European north of Russia. Gigiena i sanitariya (Hygiene and Sanitation, Russian journal). 2015; 94(1): 68–72. (in Russian)
  10. Mintel’ M.V., Zemlyanova M.A., Zhdanova-Zaplesvichko I.G. Some aspects of synergistic action of aluminum and fluorine on human body (literature review). Ekologiya cheloveka. 2018; (9): 12–7. https://doi.org/10.33396/1728-0869-2018-9-12-17 (in Russian)
  11. Kurzeja E., Pawłowska-Góral K., Burzyński M., Bycina K. The effects of exposure time and fluorine concentration on cell homeostasis. Med. Środow. 2015; 18(3): 12–6.
  12. Zuo H., Chen L., Kong M., Qiu L., Lü P., Wu P., et al. Toxic effects of fluoride on organisms. Life Sci. 2018; 198: 18–24. https://doi.org/10.1016/j.lfs.2018.02.001
  13. Galatenko A.G. Simulation of toxic liver damage in small laboratory animals. Sovremennye aspekty sanatorno-kurortnogo lecheniya i reabilitatsii na etapakh okazaniya meditsinskoy pomoshchi detskomu i vzroslomu naseleniyu. 2017; (1): 158–70. (in Russian)
  14. SanPiN 1.2.3685-21. Hygienic standards and requirements for ensuring the safety and (or) harmlessness to humans of environmental factors. Moscow; 2021. (in Russian)
  15. Bugaeva M.S., Bondarev O.I., Mikhaylova N.N., Gorokhova L.G. Comparative assessment of the morphological mechanisms of maintaining the structural homeostasis of the liver in the dynamics of the impact on the body of coal-rock dust and sodium fluoride. Meditsina truda i promyshlennaya ekologiya. 2020; 60(3): 189–94. https://doi.org/10.31089/1026-9428-2020-60-3-189-194 (in Russian)
  16. Yadykina T.K., Zhukova A.G., Ulanova E.V., Kizichenko N.V., Shcherbakova D.A., Bugaeva M.S. Functional and metabolic response of the hepatobiliary system to fluoride intoxication (experimental studies). Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk. 2010; (4): 64–8. (in Russian)
  17. Zhukova A.G., Mikhaylova N.N., Kazitskaya A.S., Alekhina D.A. Contemporary concepts of molecular mechanisms of the physiological and toxic effects of fluorine compounds on an organism. Meditsina v Kuzbasse. 2017; 16(3): 4–11. (in Russian)
  18. Zhukova A.G., Mikhaylova N.N., Yadykina T.K., Alekhina D.A., Gorokhova L.G., Romanenko D.V., et al. Experimental studies of the intracellular defense mechanisms of the liver in the development of chronic fluoride intoxication. Meditsina truda i promyshlennaya ekologiya. 2016; 56(5): 21–4. (in Russian)
  19. Voloshchuk O.N., Kopyl’chuk G.P., Buchkovskaya I.M. Activity of the marker liver enzymes under the conditions of toxic hepatitis and alimentary deprivation of protein. Eksperimental’naya i klinicheskaya gastroenterologiya. 2014; (8): 96–100. (in Russian)
  20. Lyzikov A.N., Skuratov A.G., Osipov B.B. Mechanisms of liver regeneration in normal and pathologic conditions. Problemy zdorov’ya i ekologii. 2015; (1): 4–9. (in Russian)
  21. Roslaya N.A., Likhacheva E.I., Oranskiy I.E., Odinokaya V.A., Plotko E.G., Zhovtyak E.P., et al. Clinical and pathogenetic features of chronic occupational toxicity with fluorine compounds in modern conditions. Meditsina truda i promyshlennaya ekologiya. 2012; 52(11): 17–22. (in Russian)
  22. Gaydash A.A., Babenko O.A., Bashirov R.S. Ultrastructure of the liver under the action of low doses of fluoride. Byulleten’ Sibirskoy meditsiny. 2011; 10(3): 168–70. (in Russian)
  23. Levitskiy A.P., Gorokhivskiy V.N., Selivanskaya I.A. Hepatotoxic effect of fluorides and the role of calcium-containing drugs in its prevention. Aktual’nye problemy transportnoy meditsiny. 2014; (3): 136–9. (in Russian)

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