Prospects of using Securinega suffruticosa (Securinega suffruticosa (Pall.) Rehd.) as a dietary supplement for theprevention of occupation-caused polyneuropathy (literary review)
- Authors: Gorokhova L.G.1,2, Zhukova A.G.1,2, Izmailov A.I.2, Mikhailova N.N.1
-
Affiliations:
- Research Institute for Complex Problems of Hygiene and Occupational Diseases
- Kuzbass Humanitarian and Pedagogical Institute of the Kemerovo State University
- Issue: Vol 102, No 4 (2023)
- Pages: 339-344
- Section: OCCUPATIONAL HEALTH
- Published: 29.05.2023
- URL: https://rjpbr.com/0016-9900/article/view/638578
- DOI: https://doi.org/10.47470/0016-9900-2023-102-4-339-344
- EDN: https://elibrary.ru/ugafue
- ID: 638578
Cite item
Full Text
Abstract
Polyneuropathy is the syndrome of vibration disease, which occupies one of the leading places in the structure of occupational diseases in industrialized regions. Vibration impact on the body causes a change in neurohumoral control, functional parameters of the nervous system, leads to the development of tissue hypoxia and damage to the cells of various organs. The key direction in the elaboration of means for the prevention of these disorders is the search for new biologically active compounds with adaptogenic properties. Of particular interest as a medicinal raw material is suffruticous Securinega (Securinega suffruticosa (Pall.) Rehd.). In the extracts of this plant there were found following biologically active compounds: alkaloids, terpenoids, unsaturated styrenes, glycosides, saponins, phenolic compounds, flavonoids, etc. The most studied alkaloid, securinine, has a wide range of pharmacological activity: anticancer, antimicrobial, and stimulating effects on the central nervous system.
The review describes the molecular and cellular mechanisms of the adaptogenic action of Securinega in various pathological conditions. In vitro and in vivo experiments extracts from Securinega suffruticosa (Pall.) Rehd. were shown to exhibit anti-inflammatory activity, improve cell metabolism, and have antioxidant properties. It has been established that Securinega can be a potential therapeutic agent for early atherosclerosis, for the treatment of neurodegenerative diseases associated with systemic neuroinflammatory processes. Continuing the study of the biological effect of the plant can become the base for its scientifically justified preventive use when workers are exposed to harmful production factors, including local and whole-body vibration.
The review was prepared using the MedLine, PubMed, Web of Science, Scopus, Google Scholar, CyberLeninka, and RSCI databases.
Contribution:
Gorokhova L.G. — the concept and design of the study, collection of material and data processing, writing the text;
Zhukova A.G. — the concept and design of the study, writing the text;
Izmailov A.I. — collection of material and data processing, writing the text;
Mikhailova N.N. — writing the text, editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.
Conflict of interest. The authors declare no conflict of interest.
Acknowledgement. The study had no sponsorship.
Received: January 5, 2022 / Accepted: March 24, 2023 / Published: May 29, 2023
Keywords
About the authors
Larisa G. Gorokhova
Research Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the Kemerovo State University
Author for correspondence.
Email: ponomarikova@mail.ru
ORCID iD: 0000-0002-0545-631X
MD, PhD, leading researcher of the molecular-genetic and experimental study laboratory, Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation.
e-mail: ponomarikova@mail.ru
Russian FederationAnna G. Zhukova
Research Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the Kemerovo State University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-4797-7842
Russian Federation
Anton I. Izmailov
Kuzbass Humanitarian and Pedagogical Institute of the Kemerovo State University
Email: noemail@neicon.ru
ORCID iD: 0000-0001-8966-1910
Russian Federation
Nadezhda N. Mikhailova
Research Institute for Complex Problems of Hygiene and Occupational Diseases
Email: noemail@neicon.ru
ORCID iD: 0000-0002-1127-6980
Russian Federation
References
- Petrov A.G., Semenikhin V.A., Glembotskaya G.T., Khoroshilova O.V. The methodological basis for developing and implementing a pharmacoprophylactic component of specialized pharmaceutical care in occupational diseases. Farmatsiya. 2020; 69(4): 40–6. https://doi.org/10.29296/25419218-2020-04-06 https://elibrary.ru/sbpaxf (in Russian)
- Karamova L.M., Shaykhlislamova E.R., Basharova A.V., Vlasova N.V. Occupational diseases of peripheral nervous system in Bashkortostan Republic. Meditsina truda i promyshlennaya ekologiya. 2019; 59(3): 155–61. https://doi.org/10.31089/1026-9428-2019-3-155-161 https://elibrary.ru/swivsh (in Russian)
- Katamanova E.V., Bichev S.S., Nurbaeva D.Zh. Value of brain structure dysfunction in pathogenesis and formation of clinical picture of vibration induced disease. Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk. 2012; (1): 32–6. https://elibrary.ru/pbtymn (in Russian)
- Yakimova N.L., Pankov V.A., Lizarev A.V., Rukavishnikov V.S., Kuleshova M.V., Katamanova E.V., et al. Neurophysiological and morphological effects in the post-exposure vibration period during experimental modeling. Meditsina truda i promyshlennaya ekologiya. 2019; 59(5): 284–90. https://doi.org/10.31089/1026-9428-2019-59-5-284-290 https://elibrary.ru/wlxbbf (in Russian)
- Chudinova O.A., Borzunova Yu.M., Samokhvalova G.N., Fedorov A.A., Venediktov D.L., Budlyanskaya S.V. Systemic approach to organization of prevention and treatment of vibration disease. Meditsina truda i promyshlennaya ekologiya. 2010; 50(2): 23–5. https://elibrary.ru/lbfmgj (in Russian)
- Antoshina L.I., Saarkoppel’ L.M., Pavlovskaya N.A. Influence of vibration on biochemical values characterizing oxidative metabolism, immunity, metabolism in muscular and connective tissues (review of literature). Meditsina truda i promyshlennaya ekologiya. 2009; 49(2): 32–7. https://elibrary.ru/kmkuhp (in Russian)
- Vasil’eva L.S., Slivnitsyna N.V., Lakhman O.L. Postural disorders in patients with vibration disease. Meditsina truda i promyshlennaya ekologiya. 2019; 59(5): 314–8. https://doi.org/10.31089/1026-9428-2019-59-5-314-318 https://elibrary.ru/duhluu (in Russian)
- Korotenko O.Yu., Panev N.I., Korchagina Yu.S., Panev R.N., Danilov I.P. Formation of pathology of internal organs in miners with vibration disease. Meditsina truda i promyshlennaya ekologiya. 2020; 60(6): 399–403. https://doi.org/10.31089/1026-9428-2020-60-6-399-403 https://elibrary.ru/tuzqfq (in Russian)
- Troshin V.V., Morozova P.N. Role of cerebrovascular pathology. Systemic prevention of vibration disease in workers of engineering and metal-working industries. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2015; (1): 24–7. https://elibrary.ru/tqmidl (in Russian)
- Yamshchikova A.V., Fleyshman A.N., Gidayatova M.O. Co-morbid conditions in the vibration disease patients. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2019; 98(7): 718–22. https://doi.org/10.18821/0016-9900-2019-98-7-718-722 https://elibrary.ru/afhzba (in Russian)
- Kurchevenko S.I., Bodienkova G.M. Formation of natural body reactivity when exposed to industrial physical factors. XXI vek. Tekhnosfernaya bezopasnost’. 2016; 1(4): 73–8. https://elibrary.ru/uuysby (in Russian)
- Bodienkova G.M., Kurchevenko S.I., Rusanova D.V. Role of cytokines in developmental disorders peripheral nervous system in vibration induced diseases. Rossiyskiy immunologicheskiy zhurnal. 2017; 20(1): 58–63. https://elibrary.ru/yndqip (in Russian)
- Bodienkova G.M., Kurchevenko S.I. Assessment of inflammation mediators under exposure to the vibration in employees in dependence on pronouncement of the pathological process. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2017; 96(5): 460–2. https://doi.org/10.18821/0016-9900-2017-96-5-460-462 https://elibrary.ru/ysqdhb (in Russian)
- Malyutina N.N., Bolotova A.F., Eremeev R.B., Gil’manov A.Zh., Sosnin D.Yu. Antioxidant status of blood in patients with vibration disease. Meditsina truda i promyshlennaya ekologiya. 2019; 59(12): 978–82. https://doi.org/10.31089/1026-9428-2019-59-12-978-982 https://elibrary.ru/zpvtxp (in Russian)
- Zhukova A.G., Kizichenko N.V., Gorokhova L.G., Kazitskaya A.S. Experimental models of vibration disease (literature review). Gigiena i Sanitariya (Hygiene and Sanitation, Russian Journal). 2022; 101(7): 776–82. https://doi.org/10.47470/0016-9900-2022-101-7-776-782 https://elibrary.ru/ldcxri (in Russian)
- Kuleshova M.V., Pankov V.A., D’yakovich M.P., Rukavishnikov V.S., Slivnitsyna N.V., Kazakova P.V., et al. The vibration disease in workers of the aircraft enterprise: factors of the formation, clinical manifestations, social-psychological features (dynamic following-up). Gigiena i Sanitariya (Hygiene and Sanitation, Russian Journal). 2018; 97(10): 915–20. https://doi.org/10.18821/0016-9900-2018-97-10-915-920 https://elibrary.ru/skozpr (in Russian)
- Kurzanov A.N., Zabolotskikh N.V., Kovalev D.V., Buziashvili L.A. Improving the assessment of the functional reserves of the body is a priority direction for the development of prenosological diagnostics of premorbid conditions. Mezhdunarodnyy zhurnal eksperimental’nogo obrazovaniya. 2015; (10–1): 67–70. https://elibrary.ru/uiznsz (in Russian)
- Kurchevenko S.I., Bodienkova G.M. The pre-nosologic diagnostic of vibration disease. Klinicheskaya laboratornaya diagnostika. 2017; 62(8): 482–5. https://doi.org/10.18821/0869-2084-2017-62-8-482-485 https://elibrary.ru/zfmcxh (in Russian)
- Lopatina A.B. Functional mechanisms of formation of adaptation. Uspekhi sovremennoy nauki. 2016; 3(10): 113–5. https://elibrary.ru/xciixp (in Russian)
- Miryutova N.F., Samoylova I.M., Barabash L.V., Tsekhmeystruk E.A. Prevention of pre-nosological disorders in river transport personnel. Sovremennye voprosy biomeditsiny. 2021; 5(4): 4. https://doi.org/10.51871/2588-0500_2021_05_04_4 https://elibrary.ru/ozvbdd (in Russian)
- Troshin V.V. The professional neurotoxicoses. Meditsinskiy al’manakh. 2010; (2): 52–61. https://elibrary.ru/mbfpxn (in Russian)
- Zakharenkov V.V., Mikhaylova N.N., Gorokhova L.G., Romanenko D.V., Zhukova A.G., Bugaeva M.S., et al. Method of prevention of anthracosilicosis in experimental simulation. Patent RF № 2611935; 2016. (in Russian)
- Mikhaylova N.N., Zhukova A.G., Gorokhova L.G., Kizichenko N.V., Bugaeva M.S. A method of preventing chronic fluoride intoxication when modeling in the experiment. Patent RF № 2673488; 2018. (in Russian)
- Zhukova A.G., Mikhailova N.N., Zhdanova N.N., Kazitskaya A.S., Bugaeva M.S., Gorokhova L.G. Participation of free-radical processes in structural and metabolic disturbances in the lung tissues caused by exposure to coal-rock dust and their adaptogenic correction. Bull. Exp. Biol. Med. 2020; 168(4): 439–43. https://doi.org/10.1007/s10517-020-04727-7
- Shantanova L.N., Ubasheev I.O., Nikolaev S.M., Tsyrenzhapova O.D., Bal’khaev I.M. On the role of liver in optimization of the adaptive process in human organism. Sibirskiy meditsinskiy zhurnal (Irkutsk). 2014; 125(2): 11–5. https://elibrary.ru/sfpjrz (in Russian)
- Ivanova K.S., Shantanova I.K., Bal’khaev I.M., Lonshakova L.N. The effects of phytoadaptogene «polyphytoton» on the structure of white rat’s adrenal by immobilizative stress. Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk. 2011; (1–2): 142–4. https://elibrary.ru/ohhxan (in Russian)
- Kurbanov U.Kh., Tashkhodzhaev B., Levkovich M.G., Bruskov V.P., Mukarramov N.I., Abdullaev N.D. Main alkaloids of Securinega suffruticosa. Nitrogen atom inversion in securinine. J. Struct. Chem. 2019; 60(9): 1489–95. https://doi.org/10.1134/S0022476619090142 https://elibrary.ru/fvlnwx
- Gorovoy P.G., Balyshev M.E. Possibilities and prospect applications of medicinal plants in Russian Far East. Tikhookeanskiy meditsinskiy zhurnal. 2017; (3): 5–14. https://doi.org/10.17238/PmJ1609-1175.2017.3.5-14 https://elibrary.ru/zhtxjv (in Russian)
- He Q.F., Wu Z.L., Li L., Sun W.Y., Wang G.Y., Jiang R.W., et al. Discovery of neuritogenic Securinega alkaloids from Flueggea suffruticosa by a building blocks-based molecular network strategy. Angew. Chem. Int. Ed. Engl. 2021; 60(36): 19609–13. https://doi.org/10.1002/anie.202103878
- Shevchuk O.M., Logvinenko L.A. The Far East flora medicinal plants in the collection of the Nikitsky botanical gardens. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii. 2018; 21(10): 119–24. https://doi.org/10.29296/25877313-2018-10-22 https://elibrary.ru/vkmpug (in Russian)
- Turova A.D., Sapozhnikova E.N. Medicinal Plants of the USSR and Their Application [Lekarstvennye rasteniya SSSR i ikh primenenie]. Moscow: Meditsina; 1984. (in Russian)
- Vidyadhar S., Sheela T., Kunar L.Sh., Gopal T.K., Chamundeeswari D., Saidulu A., et al. In vitro antioxidant activity of chloroform extract of aerial parts of Securinega leucopyrus (willd.) Muell. Der Farmacia Lettre. 2010; 2(6): 252–6.
- Raj D., Kokotkiewicz A., Luczkiewicz M. Production of therapeutically relevant indolizidine alkaloids in Securinega suffruticosa in vitro shoots maintained in liquid culture systems. Appl. Biochem. Biotechnol. 2015; 175(3): 1576–87. https://doi.org/10.1007/s12010-014-1386-0
- Raj D., Luczkiewicz M. Securinega suffruticosa. Fitoterapia. 2008; 79(6): 419–27. https://doi.org/10.1016/j.fitote.2008.02.011
- Garba M.M., Jamilu Y., Muhammad M.A., Akpojo A.J., Abdu-Aguye I., Marte H.I. Securinega virosa (Euphorbiaceae) root bark extract inhibits glioblastoma multiforme cell survival in vitro. Afr. J. Pharm. Pharmacol. 2015; 9(27): 684–93. https://doi.org/10.5897/AJPP2014.4221
- Xu Y.H., Wang N.S. Review and analysis of present status of the micronization of Chinese traditional medicine. Zhongguo Zhong Yao Za Zhi. 2004; 29(6): 497–500. (in Chinese)
- Bulugahapitiya V.P., Munasinghe A.B., Hettihewa M. Investigation of chemical composition of flueggea leucopyrus (willd.). World J. Pharm. Pharm. Sci. 2014; 3(8): 79–94.
- Kumar G.N., Kumar V., Sambhaji D.T., Naria M.K. A wonderful medicinal plant: Securinega leucopyrus (Willd) Muell – a brief review. Int. J. Sci. Invent. Today. 2016; 5(6): 472–84.
- Klochkov S.G., Neganova M.E. Securinine alkaloid as a promising basis for the creation of potential drugs. In: Molecular and Biological Aspects of Chemistry, Pharmaceutics and Pharmacology. Collection of Abstracts of the Sixth Interdisciplinary Conference [Molekulyarnye i Biologicheskie aspekty Khimii, Farmatsevtiki i Farmakologii. Sbornik tezisov dokladov Shestoy Mezhdistsiplinarnoy konferentsii]. Moscow: Pero; 2020: 46. https://elibrary.ru/kicohr (in Russian)
- Chirkin E., Atkatlian W., Porée F.H. The Securinega alkaloids. Alkaloids Chem. Biol. 2015; 74: 1–120. https://doi.org/10.1016/bs.alkal.2014.11.001
- Wabuyele S.L., Wald D., Xu Y. Development and validation of LC-MS/MS method for quantitative determination of (-)-securinine in mouse plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2014; 960: 19–26. https://doi.org/10.1016/j.jchromb.2014.04.011
- Li T.S.C. Chinese and Related North American Herbs: Phytopharmacology and Therapeutic Values. Boca Raton: CRC Press; 2002. https://doi.org/10.1201/9781420031881
- Park K.J., Kim C.S., Khan Z., Oh J., Kim S.Y., Choi S.U., et al. Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities. J. Nat. Prod. 2019; 82(5): 1345–53. https://doi.org/10.1021/acs.jnatprod.9b00142
- Ohsaki A., Kobayashi Y., Yoneda K., Kishida A., Ishiyama H. Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis. J. Nat. Prod. 2007; 70(12): 2003–5. https://doi.org/10.1021/np0780102
- Leonoudakis D., Rane A., Angeli S., Lithgow G.J., Andersen J.K., Chinta S.J. Anti-inflammatory and neuroprotective role of natural product securinine in activated glial cells: implications for parkinson’s disease. Mediators Inflamm. 2017; 2017: 8302636. https://doi.org/10.1155/2017/8302636
- Mendis A.S., Thabrew I., Samarakoon S.R., Tennekoon K.H. Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes. BMC Complement. Altern. Med. 2015; 15: 404. https://doi.org/10.1186/s12906-015-0927-6
- Ajmeer A.S., Dudhamal T.S., Gupta S.K. Management of Madhumehajanya Vrana (diabetic wound) with Katupila (Securinega leucopyrus [Willd] Muell.) Kalka. Ayu. 2015; 36(3): 351–5. https://doi.org/10.4103/0974-8520.182744
- Roginsky V., Lissi E.A. Review of methods to determine chain-breaking antioxidant activity in food. Food Chem. 2005; 92(2): 235–54. https://doi.org/10.1016/j.foodchem.2004.08.004
- Madhu C.S., Manukumar H.M., Basavaraju P. New-vista in finding antioxidant and anti-inflammatory property of crude protein extract from Sauropus androgynus leaf. Acta Sci. Pol. Technol. Aliment. 2014; 13(4): 375–83. https://doi.org/10.17306/j.afs.2014.4.4
- Gopal T.K., Sheela T., Chamundeeswari D., Umamaheswara C. Investigation of in-vitro anti-oxidant, anti-inflammatory and anti-arthritic activity of aerial parts of Securinega leucopyrus (Willd.) Muell. Ind. J. Res. Pharm. Biotechnol. 2013; 1(3): 371–8.
- Han B.H., Song C.H., Yoon J.J., Kim H.Y., Seo C.S., Kang D.G., et al. Anti-vascular inflammatory effect of ethanol extract from Securinega suffruticosa in human umbilical vein endothelial cells. Nutrients. 2020; 12(11): 3448. https://doi.org/10.3390/nu12113448
- Lee Y.J., Han B.H., Yoon J.J., Kim H.Y., Ahn Y.M., Hong M.H., et al. Identification of securinine as vascular protective agent targeting atherosclerosis in vascular endothelial cells, smooth muscle cells, and apolipoprotein E deficient mice. Phytomedicine. 2021; 81: 153430. https://doi.org/10.1016/j.phymed.2020.153430
- Kwak S.C., Jeong D.H., Cheon Y.H., Lee C.H., Yoon K.H., Kim J.Y., et al. Securinine suppresses osteoclastogenesis and ameliorates inflammatory bone loss. Phytother. Res. 2020; 34(11): 3029–40. https://doi.org/10.1002/ptr.6735
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