Анализ идентичных районов гомозиготности в геноме кур яичного направления продуктивности и кур декоративных пород

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Искусственный и естественный отбор значительно увеличили фенотипическую и генетическую дифференциацию пород кур. Адаптация к условиям окружающей среды, включая акклиматизацию к суровому климату, оставила «следы» отбора в архитектуре генома многих пород. Поэтому мониторинг генетической изменчивости малочисленных пород кур является важной частью программ разведения и сохранения популяций домашней птицы. На основе результатов генотипирования пород кур с помощью чипа Illumina 60K Single Nucleotide Polymorphism (SNP) был проведен биоинформационный анализ кур яичного направления продуктивности и декоративных пород. Прогоны гомозиготности (ROH) были исследованы у яичных пород – чешской золотистой (ЧЗ), леггорн светло-коричневой (итальянская куропатчатая) (ИК) и декоративных пород – голландской белохохлой черной (ГБ) и гамбургской пятнистой карликовой (ГПК). Среднее число ROH в хромосомах кур варьировало от 200 ± 6 в ГБ до 287 ± 5 в ИК, а коэффициент инбридинга был от 0.29 ± 0.04 в ГБ до 0.50 ± 0.013 в ГПК. Среди изученных пород кур из 40 идентифицированных ROH-островков восемь идентичных островков были обнаружены у двух или трех пород кур. Эти ROH-островки были расположены на GGA1, GGA2, GGA7, GGA11 и GGA25. Гены в ROH-островках были ассоциированы с массой цыпленка, жировым обменом, потреблением корма, весом яичного желтка, расклевыванием перьев и молекулярными процессами, участвующими в репликации ДНК и процессинге мРНК. Феномен идентичных ROH-островков у разных пород обсуждается в контексте селекции.

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М. Г. Смарагдов

Федеральный исследовательский центр животноводства – ВИЖ им. акад. Л.К. Эрнста

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Email: mik7252@yandex.ru

Всероссийский научно-исследовательский институт генетики и разведения сельскохозяйственных животных

Россия, Санкт-Петербург, Пушкин

Н. В. Дементьева

Федеральный исследовательский центр животноводства – ВИЖ им. акад. Л.К. Эрнста

Email: mik7252@yandex.ru

Всероссийский научно-исследовательский институт генетики и разведения сельскохозяйственных животных

Россия, Санкт-Петербург, Пушкин

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