Comparative Analysis of Mutation in the Buccal Epithelium and Blood in Patients with Lung Cancer and Healthy People

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Lung cancer is one of the leading causes of cancer death. Finding new methods for the early and accurate diagnosis of lung cancer is critical for effective treatment. We have shown that patients with lung cancer have more mutations in the FLT3, PDGFRA, KDR, PIK3CA, HRAS, FGFR3 genes in the buccal epithelium than people without diagnosed lung cancer. Thus, study of molecular alterations may be used as a method for the accurate diagnosis of lung cancer in the early stages of investigational procedure.

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作者简介

O. Serzhantova

Voronezh Regional Clinical Oncological Dispensary; Voronezh State University

Email: gureev@bio.vsu.ru
俄罗斯联邦, Voronezh; Voronezh

A. Novikova

Voronezh Regional Clinical Oncological Dispensary; Voronezh State University

Email: gureev@bio.vsu.ru
俄罗斯联邦, Voronezh; Voronezh

A. Mikhailov

Voronezh Regional Clinical Oncological Dispensary

Email: gureev@bio.vsu.ru
俄罗斯联邦, Voronezh

I. Moshurov

Voronezh Regional Clinical Oncological Dispensary

Email: gureev@bio.vsu.ru
俄罗斯联邦, Voronezh

A. Gureev

Voronezh State University

编辑信件的主要联系方式.
Email: gureev@bio.vsu.ru
俄罗斯联邦, Voronezh

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2. Fig. 1. Frequency of mutations in blood (a) and buccal epithelium (b) of healthy individuals and patients with lung cancer. * - p < 0.05, differences in frequency of occurrence according to Pearson's χ2 are statistically reliable

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3. Fig. 2. Frequency of mutations in blood and buccal epithelium of patients with lung cancer. * p < 0.05, differences in frequency of occurrence according to Pearson's χ2 are statistically reliable

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4. Fig. 3. Number of different types of mutations in buccal epithelium and blood in patients with lung cancer

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