Polymorphism of antioxidant genes and overweight in children

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Аннотация

Oxidative stress is one of the components of the pathological process leading to the development of obesity. The level of formation of free radical products is controlled by the antioxidant system. Gene polymorphisms influence the level and/or activity of the encoded enzymes. The aim of the work was to investigate the association of SNP in the genes of the antioxidant system with the risk of overweight in children and adolescents. The material for the study were DNA samples from 279 overweight children and 131 children from the control group. Genotyping was performed for rs6721961 (–617G>T) NFE2L2, rs4998557 (7958G>A) SOD1, rs4880 (47C>T Ala16Val) SOD2, rs1001179 (–262C>T) CAT, rs713041 (718C>T) GPX4, rs66 2 (Gln192Arg) PON1. It has been shown that the –617GT genotype (rs6721961) NFE2L2 is associated with decreased of overweight risk children. An increased risk of developing overweight was detected for heterozygotes –262CT for rs1001179 CAT and the –262T allele. As a result of the analysis of intergenic interactions, a 6-locus genotype was identified that is associated with a reduced risk of overweight.

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Авторлар туралы

М. Shkurat

Southern Federal University; Меdical center “Nauka”

Email: lenmash@mail.ru
Ресей, 344090, Rostov-on-Don; 344000, Rostov-on-Don

E. Маshkina

Southern Federal University

Хат алмасуға жауапты Автор.
Email: lenmash@mail.ru
Ресей, 344090, Rostov-on-Don

N. Мilyutina

Southern Federal University

Email: lenmash@mail.ru
Ресей, 344090, Rostov-on-Don

E. Теplyakova

Rostov State Medical University

Email: lenmash@mail.ru
Ресей, 344022, Rostov-on-Don

Т. Shkurat

Southern Federal University; Меdical center “Nauka”

Email: lenmash@mail.ru
Ресей, 344090, Rostov-on-Don; 344000, Rostov-on-Don

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2. Fig. 1. The nature of intergenic interactions in the formation of overweight in children (Fruchterman–Reinhold dendrogram). The information value of each individual locus is represented at the vertices of the polyhedron; the information value of interaction for a pair of loci is represented on the lines connecting them (the effect of interaction between SNPs is characterized by the color of the line: red – pronounced synergy, orange – moderate synergy, green – moderate antagonism, brown – additive interaction, blue – redundancy or independence).

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