Study Using the Micronuclear Test of Radiosensitivity and Induction Radiation of Adaptive Response in Peripheral Blood Lymphocytes of Patients with Oncological Diseases

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Radiosensitivity to low and medium doses of X-ray radiation (XR) and the ability to induce a radiation adaptive response (RAR) of lymphocytes during in vitro irradiation of peripheral blood of patients with cancer were studied. The criterion for cytogenetic damage was the frequency of micronuclei (MN) in cytochalasin-blocked binucleate lymphocytes in culture. It was found that the spontaneous level of cytogenetic damage in the lymphocytes of patients was 2.6 times higher than in healthy volunteers, and there was also significant interindividual variability in values compared to the control cohort. There were no differences in mean values for radiosensitivity to low and medium doses of XR between the study groups. There was no correlation between the spontaneous level of MN in lymphocytes and the radiosensitivity of individuals in both groups. RAR was induced with the same frequency and to the same extent in lymphocytes from both patients and healthy individuals.

作者简介

V. Balakin

Physical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences

Email: strelnikova.ns@lebedev.ru

Corresponding Member of the RAS

俄罗斯联邦, Protvino

O. Rozanova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: strelnikova.ns@lebedev.ru
俄罗斯联邦, Pushchino

N. Strelnikova

Physical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: strelnikova.ns@lebedev.ru
俄罗斯联邦, Protvino

E. Smirnova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: strelnikova.ns@lebedev.ru
俄罗斯联邦, Pushchino

T. Belyakova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; Institute for High Energy Physics named by A.A. Logunov of National Research Centre “Kurchatov Institute”

Email: strelnikova.ns@lebedev.ru
俄罗斯联邦, Pushchino; Protvino

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