Cardiac lymph flow features and new possibilities of their experimental visualization

Мұқаба

Дәйексөз келтіру

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Аннотация

The aim of this study was to describe the peculiarities of myocardial lymph flow using a new combined method of visualization of the lymphatic system. The study was performed on pig hearts harvested from a local abbatoir. The original dye, consisting of lipid-soluble chlorophyll and lipiodol, was injected stepwise into the lymphatic vessels. After sufficient optical identification of the lymphatic vessels, continuous injection of air into the coronary arteries was performed and CT scans were done. In this way, both optical and radiologic visibility of the cardiac lymphatic system was achieved. It was shown that lymph flow of the left and most part of the right ventricle is carried out through lymphatic collectors of the anterior wall of the heart, including retrogradely with respect to the right coronary artery, which complements the previously known facts about the structure of the lymphatic system of the heart.

Толық мәтін

Рұқсат жабық

Авторлар туралы

P. Yablonsky

St. Petersburg State University

Хат алмасуға жауапты Автор.
Email: pavel.yablonski@gmail.com

Laboratory of microangiopathic mechanisms of atherogenesis

Ресей, St. Petersburg

A. Lazareva

Leningrad Regional Hospital

Email: pavel.yablonski@gmail.com
Ресей, St. Petersburg

I. Garapach

State Research Institute of Phthisiopulmonology

Email: pavel.yablonski@gmail.com
Ресей, St. Petersburg

A. Yablonskaia

St. Petersburg State University

Email: pavel.yablonski@gmail.com

Laboratory of microangiopathic mechanisms of atherogenesis

Ресей, St. Petersburg

S. Orlov

St. Petersburg State University

Email: pavel.yablonski@gmail.com

Laboratory of microangiopathic mechanisms of atherogenesis; Corresponding Member of the RAS

Ресей, St. Petersburg

Әдебиет тізімі

  1. Solti F., Lengyel E., Jellinek H., et al. Coronary arteriopathy after lymphatic blockade: an experimental study in dogs. Lymphology [Internet] 1994; 27: 173–180.
  2. Martel C., Li W., Fulp B., et al. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. Journal of Clinical Investigation 2013; 123: 1571–1579.
  3. Klüsch V., Boyle E.C., Rustum S., et al. Chronic unilateral arm lymphedema correlates with increased intima-media thickness in the brachial artery. Vasa [Internet] 2022; 51: 19–23.
  4. Kappler B., Pabittel D., van Tuijl S., et al. Feasibility of mapping and cannulation of the porcine epicardial lymphatic system for sampling and decompression in heart failure research. J Clin Transl Res [Internet] 2018.
  5. Riquet M., Le Pimpec-Barthes F., Hidden G. Lymphatic drainage of the pericardium to the mediastinal lymph nodes. Surgical and Radiologic Anatomy 2001; 23: 317–319.
  6. Riquet M., Souilamas R., Hubsch J.P., et al. Lymphatic drainage of heart and lungs: Comparison between pig and man. Surgical and Radiologic Anatomy 2000; 22: 47–50.
  7. Eliška O., Elišková M. Lymphatic drainage of the ventricular conduction system in man and in the dog. Acta Anat (Basel) 1980; 107: 205–213.
  8. Johnson R.A., Blake T.M. Lymphatics of the Heart. Сirculation 1966; 33: 137–142.
  9. Kappler B., Pabittel D., van Tuijl S., et al. Feasibility of mapping and cannulation of the porcine epicardial lymphatic system for sampling and decompression in heart failure research. Journal of Clinical and Translational Research 2018.
  10. Drozdz K., Janczak D., Dziegiel P., et al. Adventitial lymphatics of internal carotid artery in healthy and atherosclerotic vessels. // Folia Histochem Cytobiol Polish Histochemical and Cytochemical Society; 2008; 46: 433–436.
  11. Drozdz K., Janczak D., Dziegiel P., et al. Adventitial lymphatics and atherosclerosis. Lymphology 2012; 45: 26–33.
  12. Kungurtsev V.V., Shimanko A.I., Vechkov S.S., et al. Stimuliatsiia limfaticheskogo drenazha tkanei v lechenii bol’nykh s zabolevaniiami arterii. // Khirurgiia (Sofiia) 1996; 42–45.
  13. Yamamoto K., Sakakura K., Adachi Y., et al. Comparison of mid-term clinical outcomes between “complete full-metal jacket strategy” versus “incomplete full-metal jacket strategy” for diffuse right coronary artery stenosis with drug-eluting stents. J Cardiol 2017; 69: 823–829.
  14. Dola J., Morawiec B., Wańha W., et al. Results of PCI with Drug-Eluting Stents in an All-Comer Population Depending on Vessel Diameter. // J Clin Med 2020; 9.

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Әрекет
1. JATS XML
2. Fig. 1. CT scan of the porcine heart. Shown are the anterior interventricular artery (LAD – red arrow) injected with air and the anterior lymphatic trunk (ALT – green arrow) injected with the original dye, the latter forming a bridge over the coronary vessel.

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3. Fig. 2. 3D reconstructed CT image of the porcine heart. Shown are the LMCA (red arrow) injected with air and the ALC (green arrow) injected with the original dye.

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4. Fig. 3. 3D reconstructed CT image of the pig heart. A – inferior wall of the heart, B – anterior wall of the heart. Red – coronary arteries, green – anterior lymphatic collector (ALC), yellow – posterior lymphatic collector. The beginning of the ALC on the inferior wall of the heart is visible.

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5. Fig. 4. View of the pig heart after injection of the lymphatic vessels with the original dye, distal (left) and proximal (right) sections of the left coronary artery, including the loop in the bifurcation area of ​​the left coronary artery trunk.

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