SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

A new series of 1-[ω-(bromophenoxy) has been synthesizedalkyl]-uracil derivatives containing naphthalene-1-yl-, naphthalene-2-yl-, 1-brominaphthalene-2-ilmethyl, benzyl and anthracene-9-ilmethyl fragments in position 3 of uracil. Antiviral properties of synthesized compounds against human cytomegalovirus were studied. It was found that the compound, which has a bridge consisting of five methylene groups, has high anti-cytomegalovirus activity in vitro. uracil

Авторлар туралы

M. Paramonova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

E. Gureeva

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

A. Ozerova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

R. Snoeck

Rega Institute for Medical Research, KU Leuven

Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

G. Andrei

Rega Institute for Medical Research, KU Leuven

Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

D. Alexandrov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

A. Khandazhinskaya

V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

M. Novikova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

S. Kochetkov

V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

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© М.П. Парамонова, Е.С. Гуреева, А.А. Озеров, R. Snoeck, G. Andrei, Д.А. Александров, А.Л. Хандажинская, М.С. Новиков, С.Н. Кочетков, 2023