Hyperthermia in the treatment of patients with non-oncological diseases (literature review)

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Abstract

An electronic search for publications on the results of the use of hyperthermia (HT) in medicine was carried out using the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI, international and regional journals, materials of international congresses, congresses and conferences. The review analyzes the results of experimental and clinical studies on local hyperthermia (LHT) in inflammatory, allergic and other diseases. In vitro experiments have shown that LHT increases the antibacterial activity of serum, as well as the expression of anti-inflammatory cytokines. Clinical studies have established a therapeutic effect of LHT in rhinitis of various etiologies, purulent sinusitis, viral human papilloma, fibromyalgia, injuries of the musculoskeletal system, chronic prostatitis. Analysis shows that the therapeutic effect of LHT is associated not only with direct bacteriostatic and bactericidal actions, but also with an indirect effect on the course of the disease, namely, modulation of the activity of antigen-presenting cells, increased blood and lymph circulation, and increased metabolism. It is also important that LHT increases the effectiveness of antibiotic therapy in drug-resistant forms of the inflammatory process.

Thus, the wide range of biological action of LHT allows us to consider it as a promising therapeutic method in various fields of medicine.

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About the authors

Orazakhmet K. Kurpeshev

Siberian Scientific Research Institute of Hyperthermia

Author for correspondence.
Email: kurpeshev-ok@yandex.ru
ORCID iD: 0000-0003-3219-1596
SPIN-code: 2467-6046

Dr. Sci. (Med.)

Russian Federation, Iskitim-5, Novosibirsk region

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Supplementary files

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2. Figure 1. Effect of temperature on clearance of Klebsiella pneumoniae bacteria after intraperitoneal inoculation [21].

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3. Figure 2. The effect of temperature on the survival of mice after intraperitoneal inoculation with Klebsiella pneumoniae [21].

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4. Figure 3. Percentage of death of methicillin-resistant Staphylococcus aureus under different conditions of exposure to thermoliposomes loaded with ciprofloxacin [24].

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