Russian Journal of Physiotherapy, Balneology and RehabilitationRussian Journal of Physiotherapy, Balneology and RehabilitationФизиотерапия, бальнеология и реабилитация1681-34562413-2969Eco-Vector7855610.17816/1681-3456-2020-19-6-9ReviewОбзорыReview ArticleHyperthermia in the treatment of patients with non-oncological diseases (literature review)Гипертермия в лечении больных с неонкологическими заболеваниями (обзор литературы)https://orcid.org/0000-0003-3219-15962467-6046KurpeshevOrazakhmet K.КурпешевОразахмет Керимбаевич
Russian Federation

Dr. Sci. (Med.)

д.м.н.

kurpeshev-ok@yandex.ruSiberian Scientific Research Institute of HyperthermiaСибирский научно-исследовательский институт гипертермии151220201964004122108202121082021Copyright ©; 2020, Eco-VectorCopyright ©; 2020, ООО "Эко-Вектор"2020Eco-VectorООО "Эко-Вектор"https://rjpbr.com/1681-3456/article/view/78556

An electronic search for publications on the results of the use of hyperthermia (HT) in medicine was carried out using the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI, international and regional journals, materials of international congresses, congresses and conferences. The review analyzes the results of experimental and clinical studies on local hyperthermia (LHT) in inflammatory, allergic and other diseases. In vitro experiments have shown that LHT increases the antibacterial activity of serum, as well as the expression of anti-inflammatory cytokines. Clinical studies have established a therapeutic effect of LHT in rhinitis of various etiologies, purulent sinusitis, viral human papilloma, fibromyalgia, injuries of the musculoskeletal system, chronic prostatitis. Analysis shows that the therapeutic effect of LHT is associated not only with direct bacteriostatic and bactericidal actions, but also with an indirect effect on the course of the disease, namely, modulation of the activity of antigen-presenting cells, increased blood and lymph circulation, and increased metabolism. It is also important that LHT increases the effectiveness of antibiotic therapy in drug-resistant forms of the inflammatory process.

Thus, the wide range of biological action of LHT allows us to consider it as a promising therapeutic method in various fields of medicine.

Проведён электронный поиск публикаций по результатам применения метода гипертермии в медицине с использованием баз данных Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, РИНЦ, а также международных и регионарных журналов, материалов международных конгрессов, съездов и конференций. В обзоре проанализированы результаты экспериментальных и клинических исследовании по локальной гипертермии (ЛГТ) при воспалительных, аллергических и других заболеваниях. В экспериментах in vitro показано, что ЛГТ повышает антибактериальную активность сыворотки, а также экспрессию противовоспалительных цитокинов. В клинических исследованиях установлен лечебный эффект ЛГТ при ринитах различной этиологии, гнойном синусите, вирусной папилломе человека, фибромиалгии, травмах костно-мышечной системы, хронических простатитах. Такой эффект связан не только с прямым бактериостатическим и бактерицидным действием, но и опосредованным влиянием на течение заболевания, а именно модуляцией активности антигенпрезентирующих клеток, усилением крово- и лимфообращения, повышением обмена веществ. Важное значение имеет и тот факт, что ЛГТ повышает эффективность антибиотикотерапии при лекарственно-устойчивых формах воспалительного процесса.

Таким образом, широкий диапазон биологического действия ЛГТ позволяет рассматривать её как перспективный лечебный метод в различных областях медицины.

reviewhyperthermiarhinitissinusitispapillomasmusculoskeletal injuriesfibromyalgiachronic prostatitisобзоргипертермияринитысинуситыпапилломытравмы костно-мышечной системыфибромиалгияхронический простатитKurpeshev OK, Van der Zee J. Experimental bases of the use of hyperthermia in oncology. Medical Radiology and radiation safety. 2018;63(1):57–77. (In Russ). doi: 10.12737/article_5a8556b4be3e24.36808227Курпешев О.К., van der Zee J. Экспериментальные основы применения гипертермии в онкологии // Медицинская радиология и радиационная безопасность. 2018. Т. 63, № 1. С. 57–77. doi: 10.12737/article_5a8556b4be3e24.36808227Kurpeshev OK, van der Zee J. Analysis of the results of randomized trials on hyperthermia in oncology. Medical Radiology and radiation safety. 2018;63(3):52–67. (In Russ). doi: 10.12737/article_5b179d60437d54.24079640Kурпешев O.K., van der Zee J. Анализ результатов рандомизированных исследований по гипертермии в онкологии // Медицинская радиология и радиационная безопасность. 2018. Т. 63, № 3. С. 52–67. doi: 10.12737/article_5b179d60437d54.24079640Golubovskaya OA. The problem of antibiotic resistance and international efforts to overcome it. Clinical Infectology and Parasitology. 2015;1:6–11. (In Russ).Голубовская О.А. Проблема антибиотикорезистентности и международные усилия по ее преодолению // Клиническая инфектология и паразитология. 2015. № 1. С. 6–11.Chopra R, Levi-Polyachenko N, Smeltzer MS. Introduction to the special issue on thermal therapy and infectious diseases. Int J Hyperthermia. 2018;34(2):133–134. doi: 10.1080/02656736.2018.1424947Chopra R., Levi-Polyachenko N., Smeltzer M.S. Introduction to the special issue on thermal therapy and infectious diseases // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 133–134. doi: 10.1080/02656736.2018.1424947WHO. Newsletter. November 2020. World Antimicrobial Health Week 2020. (In Russ). Available from: http://vestnik.mednet.ru/content/view/1225/27/lang,ru/ВОЗ. Информационный бюллетень. Ноябрь 2020. Всемирная неделя правильного использования противомикробных препаратов 2020 г. Режим доступа: http://vestnik.mednet.ru/content/view/1225/27/lang,ru/. Дата обращения: 12.04.2020.Ibelli T, Templeton S, Levi-Polyachenko N. Progress on utilizing hyperthermia for mitigating bacterial infections. Int J Hyperthermia. 2018;34(2):144–156. doi: 10.1080/02656736.2017.1369173Ibelli T., Templeton S., Levi-Polyachenko N. Progress on utilizing hyperthermia for mitigating bacterial infections // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 144–156. doi: 10.1080/02656736.2017.1369173Cortie MB, Cortie DL, Timchenko V. Heat transfer from nanoparticles for targeted destruction of infectious organisms. Int J Hyperthermia. 2018;34(2):157–167. doi: 10.1080/02656736.2017.1410236Cortie M.B., Cortie D.L., Timchenko V. Heat transfer from nanoparticles for targeted destruction of infectious organisms // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 157–167. doi: 10.1080/02656736.2017.1410236Ricker EB, Aljaafari HA, Bader TM, et al. Thermal shock susceptibility and regrowth of pseudomonas aeruginosa biofilms. Int J Hyperthermia. 2018;34(2):168–176. doi: 10.1080/02656736.2017.1347964Ricker E.B., Aljaafari H.A., Bader T.M., et al. Thermal shock susceptibility and regrowth of Pseudomonas aeruginosa biofilms // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 168–176. doi: 10.1080/02656736.2017.1347964Li R, Kou X, Zhang L, Wang S. Inactivation kinetics of food-borne pathogens subjected to thermal treatments: a review. Int J Hyperthermia. 2018;34(2):177–188. doi: 10.1080/02656736.2017.1372643Li R., Kou X., Zhang L., Wang S. Inactivation kinetics of food-borne pathogens subjected to thermal treatments: a review // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 177–188. doi: 10.1080/02656736.2017.1372643Munaweera I, Shaikh S, Maples D, et al. Temperature-sensitive liposomal ciprofloxacin for the treatment of biofilm on infected metal implants using alternating magnetic fields. Int J Hyperthermia. 2018;34(2):189–200. doi: 10.1080/02656736.2017.1422028Munaweera I., Shaikh S., Maples D., et al. Temperature-sensitive liposomal ciprofloxacin for the treatment of biofilm on infected metal implants using alternating magnetic fields // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 189–200. doi: 10.1080/02656736.2017.1422028Nigatu AS, Ashar H, Sethuraman SN, et al. Elastin-like polypeptide incorporated thermally sensitive liposome improve antibiotic therapy against musculoskeletal bacterial pathogens. Int J Hyperthermia. 2018;34(2):201–208. doi: 10.1080/02656736.2017.1420249Nigatu A.S., Ashar H., Sethuraman S.N., et al. Elastin-like polypeptide incorporated thermally sensitive liposome improve antibiotic therapy against musculoskeletal bacterial pathogens // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 201–208. doi: 10.1080/02656736.2017.1420249Meeker DG, Wang T, Harrington WN, et al. Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilmassociated bacterial infections. Int J Hyperthermia. 2018;34(2):209–219. doi: 10.1080/02656736.2017.1392047Meeker D.G., Wang T., Harrington W.N., et al. Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilmassociated bacterial infections // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 209–219. doi: 10.1080/02656736.2017.1392047Frenkel GL. First International Congress of Pyretotherapy. Physical Therapy. 1939;5:56–59. (In Russ).Френкель Г.Л. Первый международный конгресс по пиретотерапии // Физиотерапия. 1939. Т. 5. С. 56–59.Sidi J. Non oncological applications of hyperthermia. 12th Int. Symposium on Clinical Hyperthermia. Abstracts. Rome; 1989. 71 р.Sidi J. Non oncological applications of hyperthermia. Proceedings of the Twelfth International Symposium on Clinical Hyperthermia, held April 27–30, 1989, Rome. Italy, Rome; 1989. Р. 71.Kurpeshev OK, van der Zee J. Locoregional hyperthermia of malignant tumors – techniques, thermometry, equipment. Medical Radiology and radiation safety. 2017;62(5):52–63. (In Russ). doi: 10.12737/article_59f30321207ef4.88932385Курпешев О.К., van der Zee J. Локорегионарная гипертермия злокачественных опухолей — методики, термометрия, аппаратура // Медицинская радиология и радиационная безопасность. 2017. Т. 62, № 5. С. 52–63. doi: 10.12737/article_59f30321207ef4.88932385Canters RA, Wust P, Bakker JF, van Rhoon GC. A literature survey on indicators for characterisation and optimization. of SAR distributions in deep hyperthermia, a plea for standardization. Int J Hyperthermia. 2009;25(7):593–608. doi: 10.3109/02656730903110539Canters R.A., Wust P., Bakker J.F., van Rhoon G.C. A literature survey on indicators for characterisation and optimisation of SAR distributions in deep hyperthermia, a plea for standardization // Int J Hyperthermia. 2009. Vol. 25, N 7. Р. 593–608. doi: 10.3109/02656730903110539Suvernev AV, Ivanov GV. Intensive thermotherapy. Novosibirsk: Geo; 2014. 106 p. (In Russ).Сувернев А.В., Иванов Г.В. Интенсивное теплолечение. Новосибирск: Гео, 2014. 106 с.Gũllũoğlu BM, Bekrakı A, Çerıkçıoğlu N, Sõyletır G. Immunologic influences of hyperthermia in a rat model of obstructive jaundice. Dig Dis Sci. 2001;46(11):2378–2384. doi: 10.1023/a:1012399114305Gũllũoğlu B.M., Bekrakı A., Çerıkçıoğlu N., Sõyletır G. Immunologic influences of hyperthermia in a rat model of obstructive jaundice // Dig Dis Sci. 2001. Vol. 46, N 11. P. 2378–2384. doi: 10.1023/a:1012399114305Biro S, Masuda A, Kihara T, Tei C. Clinical implications of thermal therapy in lifestyle-related diseases. Exp Biol Med. 2003;228:1245–1249. doi: 10.1177/153537020322801023Biro S., Masuda A., Kihara T., Tei C. Clinical implications of thermal therapy in lifestyle-related diseases // Exp Biol Med. 2003. Vol. 228, N 10. P. 1245–1249. doi: 10.1177/153537020322801023Pearson J, Low DA, Stöhr E, et al. Hemodynamic responses to heat stress in the resting and exercising human leg: insight into the effect of temperature on skeletal muscle blood flow. Am J Physiol Regul Integr Comp Physiol. 2011;300(3):R663–R673. doi: 10.1152/ajpregu.00662.2010Pearson J., Low D.A., Stöhr E., et al. Hemodynamic responses to heat stress in the resting and exercising human leg: insight into the effect of temperature on skeletal muscle blood flow // Am J Physiol Regul Integr Comp Physiol. 2011. Vol. 300, N 3. P. R663–R673. doi: 10.1152/ajpregu.00662.2010Jiang Q, Cross AS, Singh S, et al. Febrile core temperature is essential for optimal host defense in bacterial peritonitis. Infection and Immunity. 2000;68(3):1265–1270. doi: 10.1128/IAI.68.3.1265-1270.2000Jiang Q., Cross A.S., Singh S., et al. Febrile core temperature is essential for optimal host defense in bacterial peritonitis // Infection and Immunity. 2000. Vol. 68, N 3. Р. 1265–1270.Nagarsekar A, Greenberg RS, Shah NG, et al. Febrile-Range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils. J Immunology. 2008;181:2636–2643. doi: 10.4049/jimmunol.181.4.2636doi: 10.1128/IAI.68.3.1265-1270.2000Mackowiak PA, Marling-Cason M. Hyperthermic enhancement of serum antimicrobial activity: mechanism by which fever might exert a beneficial effect on the outcome of gram-negative sepsis. Infect Immun. 1983;39(1):38–42. doi: 10.1128/iai.39.1.38-42.1983Nagarsekar A., Greenberg R.S., Shah N.G., et al. Febrile-Range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils // J Immunology. 2008. Vol. 181, N 4. Р. 2636–2643.Nigatu AS, Ashar H, Sethuraman SN, et al. Elastin-like polypeptide incorporated thermally sensitive liposome improve antibiotic therapy against musculoskeletal bacterial pathogens. Int J Hyperthermia. 2018;34(2):201–208. doi: 10.1080/02656736.2017.1420249doi: 10.4049/jimmunol.181.4.2636Forstall GJ, Macknin ML, Yen-Lieberman BR, Medendrop SV. Effect of inhaling heated vapor on symptoms of the common cold. JAMA. 1994;271(14):1109–1111.Mackowiak P.A., Marling-Cason M. Hyperthermic enhancement of serum antimicrobial activity: mechanism by which fever might exert a beneficial effect on the outcome of gram-negative sepsis // Infect Immun. 1983. Vol. 39, N 1. Р. 38–42.Conti C, De Marco A, Mastromarino P, et al. Antiviral effect of hyperthermic treatment in rhinovirus infection. Antimicrob Agents Chemother. 1999;43(4):822–829. doi: 10.1128/AAC.43.4.822doi: 10.1128/iai.39.1.38-42.1983Thorne SH, Brooks G, Lee YL, et al. Effects of febrile temperature on adenoviral infection and replication: implications for viral therapy of cancer. J Virology. 2005;79(1):581–591. doi: 10.1128/JVI.79.1.581–591Nigatu A.S., Ashar H., Sethuraman S.N., et al. Elastin-like polypeptide incorporated thermally sensitive liposome improve antibiotic therapy against musculoskeletal bacterial pathogens // Int J Hyperthermia. 2018. Vol. 34, N 2. Р. 201–208. doi: 10.1080/02656736.2017.1420249Panasiak W, Oraczewska A, Luczak M. Influence of hyperthermia on experimental viral infections in vitro. Consensus on Hyperthermia for the 1990s. Ed. by H.I. Bicher, et al. New York: Plenum Press; 1990. Р. 471–472.Forstall G.J., Macknin M.L., Yen-Lieberman B.R., Medendrop S.V. Effect of inhaling heated vapor on symptoms of the common cold // JAMA. 1994. Vol. 271, N 14. Р. 1109–1111.Macknin ML, Mathew S, Medendorp SV. Effect of inhaling heated vapor on symptoms of the common cold. JAMA. 1990;264(8):989–991. doi: 10.1001/jama.1990.03450080075034Conti C., De Marco A., Mastromarino P., et al. Antiviral effect of hyperthermic treatment in rhinovirus infection // Antimicrob Agents Chemother. 1999. Vol. 43, N 4. Р. 822–829.Ophir D, Elad Y. Effects of steam inhalation on nasal patency and nasal symptoms in patients with the common cold. Am J Otolaryngol. 1987;8(3):149–153. doi: 10.1016/s0196-0709(87)80037-6doi: 10.1128/AAC.43.4.822Tyrrell D, Barrow I, Arthur J. Local hyperthermia benefits natural and experimental common colds. BMJ. 1989;298(6683):1280–1283. doi: 10.1136/bmj.298.6683.1280Thorne S.H., Brooks G., Lee Y-L., et al. Effects of febrile temperature on adenoviral infection and replication: implications for viral therapy of cancer // J Virology. 2005. Vol. 79, N 1. Р. 581–591.Yerushalmi A, Karman S, Lwoff A. Treatment of perennial allergic rhinitis by local hyperthermia. Proc Nat Acad Sci USA. 1982;79(15):4766–4769. doi: 10.1073/pnas.79.15.4766doi: 10.1128/JVI.79.1.581–591Singh M, Singh M, Jaiswal N, Chauhan A. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2017;8(8):CD001728. doi: 10.1002/14651858.CD001728.pub6Panasiak W., Oraczewska A., Luczak M. Influence of hyperthermia on experimental viral infections in vitro. Consensus on Hyperthermia for the 1990s. Ed. by H.I. Bicher, et al. New York: Plenum Press; 1990. Р. 471–472.Govorun MI, Kokorina OV. The use of local hyperthermia in the treatment of purulent sinusitis. Materials of the XVIII Congress of Otorhinolaryngologists of Russia. Vol. 3. Saint Petersburg; 2011. Р. 80–82. (In Russ).Macknin M.L., Mathew S., Medendorp S.V. Effect of inhaling heated vapor on symptoms of the common cold // JAMA. 1990. Vol. 264, N 8. Р. 989–991. doi: 10.1001/jama.1990.03450080075034Ivanova YV, Gusak IV. The use of microwave electromagnetic radiation in the treatment of purulent-inflammatory processes. Ukrainian Journal Of Surgery. 2009;(2):65–69. (In Russ).Ophir D., Elad Y. Effects of steam inhalation on nasal patency and nasal symptoms in patients with the common cold // American J Otolaryngology. 1987. Vol. 8, N 3. Р. 149–153.Gao X, Chen H. Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases. Front Med. 2014;8(1):1–5. doi: 10.1007/s11684-014-0309-3doi: 10.1016/s0196-0709(87)80037-6Huo W, Gao XH, Sun XP, et al. Local Hyperthermia at 44ºC for the treatment of plantar warts: a randomized, patient-blinded, placebo-controlled trial. J Infectious Diseases. 2010;201(8):1169–1172. doi: 10.1086/651506Tyrrell D., Barrow I., Arthur J. Local hyperthermia benefits natural and experimental common colds // BMJ. 1989. Vol. 298, N 6683. Р. 1280–1283. doi: 10.1136/bmj.298.6683.1280Huo W, Li GH, Qi RQ, et al. Clinical and immunologic results of local hyperthermia at 44ºC for extensive genital warts in patients with diabetes mellitus. Int J Hyperthermia. 2013;29(1):17–20. doi: 10.3109/02656736.2012.758874Yerushalmi A., Karman S., Lwoff A. Treatment of perennial allergic rhinitis by local hyperthermia // Proc Nat Acad Sci USA. 1982. Vol. 79, N 15. Р. 4766–4769. doi: 10.1073/pnas.79.15.4766Krooks J, Weatherall A, Markowitz S. Complete resolution of mycobacterium marinum infection with clarithromycin and ethambutol: a case report and a review of the literature. J Clin Aesthet Dermatol. 2018;11(12):48–51.Singh M., Singh M., Jaiswal N., Chauhan A. Heated, humidified air for the common cold // Cochrane Database Syst Rev. 2017. Vol. 8, N 8. Р. CD001728. doi: 10.1002/14651858.CD001728.pub6Lee CN, Lee YY. Local hyperthermia therapy for refractory cutaneous Mycobacterium marinum infection. Dermatologic Therapy. 2017;30(6):e12561. doi: 10.1111/dth.12561Говорун М.И., Кокорина О.В. Применение локальной гипертермии в лечении гнойных синуситов // Материалы XVIII съезда оториноларингологов России. Т. 3. Санкт-Петербург, 2011. C. 80–82.Hisamichi K, Hiruma M, Yamazaki M, et al. Efficacy of oral minocycline and hyperthermic treatment in a case of atypical mycobacterial skin infection by Mycobacterium marinum. J Dermatol. 2002;29(12):810–811. doi: 10.1111/j.1346-8138.2002.tb00228.xИванова Ю.В., Гусак И.В. Использование электромагнитного излучения СВЧ диапазона в лечении гнойно-воспалительных процессов // Український Журнал Хірургії. 2009. Т. 2. С. 65–69.Sutherland GE, Lauwasser M, NcNeely DJ, Shands JW. Heat treatment for certain chronic granulomatous skin infections. Southern Medical J. 1980;73(12):1564–1565. doi: 10.1097/00007611-198012000-00006Gao X., Chen H. Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases // Front Med. 2014. Vol. 8, N 1. Р. 1–5.Giombini A, Giovannini V, Di Cesare A, et al. Hyperthermia induced by microwave diathermy in the management of muscle and tendon injuries. Br Med Bull. 2007;83:379–396. doi: 10.1093/bmb/ldm020doi: 10.1007/s11684-014-0309-3Romeyke T, Scheuer HC, Stummer H. Fibromyalgia with severe forms of progression in a multidisciplinary therapy setting with emphasis on hyperthermia therapy – a prospective controlled study. Clin Interv Aging. 2015;1069–1079. doi: 10.2147/CIA.S74949Huo W., Gao X.-H., Sun X.-P., et al. Local Hyperthermia at 44ºC for the treatment of plantar warts: a randomized, patient-blinded, placebo-controlled trial // J Infectious Diseases. 2010. Vol. 201, N 8. Р. 1169–1172. doi: 10.1086/651506Servadio C, Leib Z. Chronic abacterial prostatitis and hyperthermia. A possible new treatment? Br J Urol. 1991;67:308–311. doi: 10.1111/J.1464-410X.1991.TB15141.XHuo W., Li G.-H., Qi R.-Q., et al. Clinical and immunologic results of local hyperthermia at 44ºC for extensive genital warts in patients with diabetes mellitus // Int J Hyperthermia. 2013. Vol. 29, N 1. Р. 17–20. doi: 10.3109/02656736.2012.758874Shah T, Watson G, Barnes D. Microwave hyperthermia in the treatment of chronic abacterial prostatitis and prostatodynia: results of a doubleblind placebo controlled trial. J Urol. 1993;149:405A. [Quoted by: Collins MM, MacDonald R, Wilt TJ. Diagnosis and Treatment of Chronic Abacterial Prostatitis: A Systematic Review. Ann Intern Med. 2000;133:367–381].Krooks J., Weatherall A., Markowitz S. Complete resolution of mycobacterium marinum infection with clarithromycin and ethambutol: a case report and a review of the literature // J Clin Aesthet Dermatol. 2018. Vol. 11, N 12. Р. 48–51.Montorsi F, Guazzoni G, Bergamaschi F, et al. Is there a role for transrectal microwave hyperthermia of the prostate in the treatment of abacterial prostatitis and prostatodynia? Prostate. 1993;22(2):139–146. doi: 10.1002/pros.2990220206Lee C.N., Lee Y.Y. Local hyperthermia therapy for refractory cutaneous Mycobacterium marinum infection // Dermatologic Therapy. 2017. Vol. 30, N 6. Р. e12561. doi: 10.1111/dth.12561Arslanov MM, Kamalov II, Fattakhov VV. Physiotherapy treatments for chronic prostatitis. Practical medicine. 2011;(1):22–24. (In Russ).Hisamichi K., Hiruma M., Yamazaki M., et al. Efficacy of oral minocycline and hyperthermic treatment in a case of atypical mycobacterial skin infection by Mycobacterium marinum // J Dermatol. 2002. Vol. 29, N 12. Р. 810–811. doi: 10.1111/j.1346-8138.2002.tb00228.xZhang Y, Sun FL, Zang T. Medication combined with local hyperthermia: a desirable therapy for chronic prostatitis pain symptoms. Zhonghua Nan Ke Xue. 2008;14(5):451–453.Sutherland G.E., Lauwasser M., NcNeely D.J., Shands J.W. Heat treatment for certain chronic granulomatous skin infections // Southern Medical J. 1980. Vol. 73, N 12. Р. 1564–1565. doi: 10.1097/00007611-198012000-00006Rigatti P, Buonaguidi A, Grasso M, et al. Morphodynamic and biochemical assessment of seminal plasma in patients who underwent local prostatic hyperthermia. Prostate. 1990;16:325–330. doi: 10.1002/pros.2990160407Giombini A., Giovannini V., Di Cesare A., et al. Hyperthermia induced by microwave diathermy in the management of muscle and tendon injuries // Br Med Bull. 2007. Vol. 83. Р. 379–396. doi: 10.1093/bmb/ldm020Jin JX, Wang HZ, Zhai ZX, et al. Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients. Asian J Androl. 2017;19(5):548–553. doi: 10.4103/1008-682X.185852Romeyke T., Scheuer H.C., Stummer H. Fibromyalgia with severe forms of progression in a multidisciplinary therapy setting with emphasis on hyperthermia therapy – a prospective controlled study // Clin Interv Aging. 2015. Р. 1069–1079. doi: 10.2147/CIA.S74949Kurpeshev OK, Konoplyannikov AG. Local electromagnetic hyperthermia in the treatment of patients with chronic prostatitis. Medical Radiology and radiation safety.1991;36(11):9–10. (In Russ).Servadio C., Leib Z. Chronic abacterial prostatitis and hyperthermia. A possible new treatment? // Br J Urol. 1991. Vol. 67. Р. 308–311. doi: 10.1111/J.1464-410X.1991.TB15141.XEngeler D (Chair), Baranowski AP, Borovicka J, et al. Guidelines on chronic pelvic pain. European Association of Urology; 2014. 132 p.Shah T., Watson G., Barnes D. Microwave hyperthermia in the treatment of chronic abacterial prostatitis and prostatodynia: results of a doubleblind placebo controlled trial // J Urol. 1993. Vol. 149. Р. 405A. [Цит. по: Collins M.M., MacDonald R., Wilt T.J. Diagnosis and treatment of chronic abacterial prostatitis: a systematic review // Ann Intern Med. 2000. Vol. 133. Р. 367–381].Kastner C, Hochreiter W, Huidobro C, et al. Cooled transurethral microwave thermotherapy for intractable chronic prostatitis – results of a pilot study after 1 year. Urology. 2004;64(6):1149–1154. doi: 10.1016/j.urology.2004.07.016Montorsi F., Guazzoni G., Bergamaschi F., et al. Is there a role for transrectal microwave hyperthermia of the prostate in the treatment of abacterial prostatitis and prostatodynia? // Prostate. 1993. Vol. 22, N 2. Р. 139–146. doi: 10.1002/pros.2990220206Engeler D (Chair), Baranowski AP, Berghmans B, et al. Guidelines on chronic pelvic pain. European Association of Urology; 2020. 88 p.Арсланов М.М., Камалов И.И., Фаттахов В.В. Физиотерапевтические методы лечения хронического простатита // Практическая медицина. 2011. № 1. Р. 22–24.Ljungnér H. Third international chronic prostatitis network transrectal thermotherapy of chronic prostatitis. Third International Chronic Prostatitis Network. 2000. Available from: http://www.prostatitis.org/a112000.htmlZhang Y., Sun FL., Zang T. Medication combined with local hyperthermia: a desirable therapy for chronic prostatitis pain symptoms // Zhonghua Nan Ke Xue. 2008. Vol. 14, N 5. Р. 451–453.Nickel JC, Sorensen R. Transurethral microwave thermotherapy for nonbacterial prostatitis: a randomized double-blind sham controlled study using new prostatitis specific assessment questionnaires. J Urol. 1996;155(6):1950–1954. discussion 1954–5. doi: 10.1016/s0022-5347(01)66056-7Rigatti P., Buonaguidi A., Grasso M., et al. Morphodynamic and biochemical assessment of seminal plasma in patients who underwent local prostatic hyperthermia // Prostate. 1990. Vol. 16, N 5. Р. 325–330. doi: 10.1002/pros.2990160407Gao M, Ding H, Zhong G, et al. The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of MDA, NO, SOD, and Zn levels in pretreatment and posttreatment. Urology. 2012;79(2):391–396. doi: 10.1016/j.urology.2011.08.046Jin J.X., Wang H.Z., Zhai Z.X., et al. Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients // Asian J Androl. 2017. Vol. 19, N 5. Р. 548–553. doi: 10.4103/1008-682X.185852Chung H, Choi H, Yoo TK, et al. The effects of microwave thermotherapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized study. Urogenit Tract Infect. 2017;12(1):35–41. doi: 10.14777/uti.2017.12.1.35Курпешев О.К., Коноплянников А.Г. Локальная электромагнитная гипертермия в лечении больных хроническим простатитом // Медицинская радиология и радиационная безопасность. 1991. Т. 36, № 11. С. 9–10.Kurpeshev OK, Tsyb AF, Mardynskiy YS. Transrectal electromagnetic hyperthermia of benign prostatic hyperplasia and chronic prostatitis. Methodological recommendations. Moscow; 2003. 21 p. (In Russ).Engeler D. (Chair), Baranowski A.P., Borovicka J, et al. Guidelines on chronic pelvic pain. European Association of Urology; 2014. 132 p.Kastner C., Hochreiter W., Huidobro C., et al. Cooled transurethral microwave thermotherapy for intractable chronic prostatitis – results of a pilot study after 1 year // Urology. 2004. Vol. 64, N 6. Р. 1149–1154. doi: 10.1016/j.urology.2004.07.016Engeler D. (Chair), Baranowski A.P., Berghmans B., et al. Guidelines on chronic pelvic pain. European Association of Urology; 2020. 88 p.Ljungnér H. Third international chronic prostatitis network transrectal thermotherapy of chronic prostatitis. Third International Chronic Prostatitis Network; 2000. Available from: http://www.prostatitis.org/a112000.htmlNickel J.C., Sorensen R. Transurethral microwave thermotherapy for nonbacterial prostatitis: a randomized double-blind sham controlled study using new prostatitis specific assessment questionnaires // J Urol. 1996. Vol. 155, N 6. Р. 1950–1954. discussion 1954-5. doi: 10.1016/s0022-5347(01)66056-7Gao M., Ding H., Zhong G., et al. The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of MDA, NO, SOD, and Zn Levels in pretreatment and posttreatment // Urology. 2012. Vol. 79, N 2. Р. 391–396. doi: 10.1016/j.urology.2011.08.046Chung H., Choi H., Yoo T.K., et al. The effects of microwave thermotherapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized study // Urogenit Tract Infect. 2017. Vol. 12, N 1. Р. 35–41. doi: 10.14777/uti.2017.12.1.35Курпешев О.К., Цыб А.Ф., Мардынский Ю.С. Трансректальная электромагнитная гипертермия доброкачественной гиперплазии предстательной железы и хронического простатита. Методические рекомендации. Москва, 2003. 21 с.