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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">71701</article-id><article-id pub-id-type="doi">10.17816/1681-3456-2020-19-5-6</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical notes and case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Заметки и наблюдения из практики</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Regression of spinal demyelination in a patient with leber's disease during long-term therapy with acupuncture and transcutaneous electroneurostimulation</article-title><trans-title-group xml:lang="ru"><trans-title>Регресс димиелинизирующего поражения спинного мозга у пациентки с болезнью Лебера на фоне длительной терапии с помощью акупунктуры и транскожной электронейростимуляции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3643-982X</contrib-id><contrib-id contrib-id-type="spin">5487-9802</contrib-id><name-alternatives><name xml:lang="en"><surname>Al-Zamil</surname><given-names>Mustafa Kh.</given-names></name><name xml:lang="ru"><surname>Аль-Замиль</surname><given-names>Мустафа Халилович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>alzamil@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">6895-0681</contrib-id><name-alternatives><name xml:lang="en"><surname>Kulikova</surname><given-names>Natalya G.</given-names></name><name xml:lang="ru"><surname>Куликова</surname><given-names>Наталья Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>alzamil@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3087-3067</contrib-id><contrib-id contrib-id-type="spin">5423-8408</contrib-id><name-alternatives><name xml:lang="en"><surname>Vasilieva</surname><given-names>Ekaterina S.</given-names></name><name xml:lang="ru"><surname>Васильева</surname><given-names>Екатерина Станиславовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>alzamil@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples' Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">LLC "Olivia" Brain and Spine Clinic</institution></aff><aff><institution xml:lang="ru">ООО «Оливия» Клиника мозга и позвоночника</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2020</year></pub-date><volume>19</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>312</fpage><lpage>316</lpage><history><date date-type="received" iso-8601-date="2021-06-18"><day>18</day><month>06</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-06-18"><day>18</day><month>06</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/71701">https://rjpbr.com/1681-3456/article/view/71701</self-uri><abstract xml:lang="en"><p><italic>In this paper, we demonstrate the effectiveness of the complex use of acupuncture and direct transcutaneous electroneurostimulation of the median, ulnar, tibial and peroneal nerves in treatment of patient with a demyelization changes in the spinal cord. At the same time, it was possible not only to reduce the severity of motor and sensory deficits, but also of Limb Spasticity, and also to cause a complete regression of demyelization changes in MRI.</italic></p></abstract><trans-abstract xml:lang="ru"><p><italic>В данной работе продемонстрирована эффективность комплексного применения акупунктуры и прямой транскожной электронейростимуляции срединных, локтевых, большеберцовых и малоберцовых нервов при лечении пациентки с димиелинизирующим поражением спинного мозга. При этом удалось не только снизить выраженность моторного и сенсорного дефицита и спастического тонуса в мышцах верхних и нижних конечностей, но и вызвать полный регресс димиелинизирующих изменений по результатам магнитно-резонансной томографии.</italic></p></trans-abstract><kwd-group xml:lang="en"><kwd>Leber's disease</kwd><kwd>transcutaneous electroneurostimulation</kwd><kwd>high-frequency low-amplitude TENS</kwd><kwd>low-frequency high-amplitude TENS</kwd><kwd>acupuncture</kwd><kwd>demyelinating diseases</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>болезнь Лебера</kwd><kwd>транскожная электронейростимуляция</kwd><kwd>высокочастотная низкоамплитудная ТЭНС</kwd><kwd>низкочастотная высокоамплитудная ТЭНС</kwd><kwd>акупунктура</kwd><kwd>демиелинизирующие заболевания</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Tobore TO. Towards a comprehensive etiopathogenetic and pathophysiological theory of multiple sclerosis. Int J Neurosci. 2020;130(3):279–300. doi: 10.1080/00207454.2019</mixed-citation><mixed-citation xml:lang="ru">Tobore T.O. Towards a comprehensive etiopathogenetic and pathophysiological theory of multiple sclerosis // Int J Neurosci. 2020. Vol. 130, N 3. P. 279–300. doi: 10.1080/00207454.2019</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Roussarie JP, Ruffie C, Brahic M. The role of myelin in Theiler’s virus persistence in the central nervous system. PLoS Pathog. 2007;3(2):e23. doi: 10.1371/journal.ppat.0030023</mixed-citation><mixed-citation xml:lang="ru">Roussarie J.P., Ruffie C., Brahic M. The role of myelin in Theiler’s virus persistence in the central nervous system // PLoS Pathog. 2007. Vol. 3, N 2. P. e23. doi: 10.1371/journal.ppat.0030023</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Theiler M. Spontaneous encephalomyelitis of mice — a new virus disease. Science. 1934;80(2066):122.doi: 10.1126/science.80.2066.122-a</mixed-citation><mixed-citation xml:lang="ru">Theiler M. Spontaneous encephalomyelitis of mice — a new virus disease // Science. 1934. Vol. 80, N 2066. P. 122.doi: 10.1126/science.80.2066.122-a</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Tsunoda I, Tanaka T, Terry EJ, Fujinami RS. Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: when can axonal injury be beneficial? Am J Pathol. 2007;170(1):214–226. doi: 10.2353/ajpath.2007.060683</mixed-citation><mixed-citation xml:lang="ru">Tsunoda I., Tanaka T., Terry E.J., Fujinami R.S. Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: when can axonal injury be beneficial? // Am J Pathol. 2007. Vol. 170, N 1. P. 214–226. doi: 10.2353/ajpath.2007.060683</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Pedley TA, Baxil CW, Morrell MJ. Epilepsy. In: Rowland LP, ed. Merritt’s Neurology. 10th. Philadelphia: Lippincott Williams &amp; Wilkins; 2000. Р. 813–833.</mixed-citation><mixed-citation xml:lang="ru">Pedley T.A., Baxil C.W., Morrell, M.J. Epilepsy. In: Rowland L.P., ed. Merritt’s Neurology. 10th. Philadelphia: Lippincott Williams &amp; Wilkins; 2000. Р. 813–833.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Stewart KA, Wilcox KS, Fujinami RS, White HS. Development of postinfection epilepsy after Theiler’s virus infection of C57BL/6 mice. J Neuropathol Exp Neurol. 2010;69(12):1210–1219.doi: 10.1097/NEN.0b013e3181ffc420</mixed-citation><mixed-citation xml:lang="ru">Stewart K.A., Wilcox K.S., Fujinami R.S., White H.S. Development of postinfection epilepsy after Theiler’s virus infection of C57BL/6 mice // J Neuropathol Exp Neurol. 2010. Vol. 69, N 12. P. 1210–1219. doi: 10.1097/NEN.0b013e3181ffc420</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Tsunoda I, Sato F, Omura S, et al. Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis. Clin Exp Neuroimmunol. 2016;7(4):330–345.doi: 10.1111/cen3.12341</mixed-citation><mixed-citation xml:lang="ru">Tsunoda I., Sato F., Omura S., et al. Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis // Clin Exp Neuroimmunol. 2016. Vol. 7, N 4. P. 330–345. doi: 10.1111/cen3.12341</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Fernández-Tenorio E. Transcutaneous electrical nerve stimulation for spasticity: A systematic review. Neurologia. 2019;34(7):451–460. doi: 10.1016/j.nrl.2016.06.009</mixed-citation><mixed-citation xml:lang="ru">Fernández-Tenorio E. Transcutaneous electrical nerve stimulation for spasticity: A systematic review // Neurologia. 2019. Vol. 34, N 7. P. 451–460. doi: 10.1016/j.nrl.2016.06.009</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Garcia MA, Vargas CD. Is somatosensory electrical stimulation effective in relieving spasticity? A systematic review. Musculoskelet Neuronal Interact. 2019;19(3):317–325.</mixed-citation><mixed-citation xml:lang="ru">Garcia M.A., Vargas C.D. Is somatosensory electrical stimulation effective in relieving spasticity? A systematic review // J Musculoskelet Neuronal Interact. 2019. Vol. 19, N 3. P. 317–325.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Mills PB, Dossa F. Transcutaneous electrical nerve stimulation for management of limb spasticity: a systematic review. Am J Phys Med Rehabil. 2016;95(4):309–318.doi: 10.1097/PHM.0000000000000437</mixed-citation><mixed-citation xml:lang="ru">Mills P.B., Dossa F. Transcutaneous electrical nerve stimulation for management of limb spasticity: a systematic review // Am J Phys Med Rehabil. 2016. Vol. 95, N 4. P. 309–318.doi: 10.1097/PHM.0000000000000437</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Rozhkova VP, Al Zamil M, Kulikova NG. The combination of demyelinating lesions of the spinal cord, brain atrophy, progressive demyelinating polyneuropathy in a patient with Leber’sdisease. Clinical Neurology. 2019;(1):3–7.</mixed-citation><mixed-citation xml:lang="ru">Рожкова В.П., Аль Замиль М., Куликова Н.Г. и др. Сочетание демиелинизирующего поражения спинного мозга, атрофии головного мозга, прогрессирующей демиелинизирующей полиневропатии у пациентов с болезнью Лебера. Клинический случай // Клиническая неврология. 2019. № 1. С. 3–7.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Al Zamil MK. To the question about the impact of tes therapy to vash indicators of pain in patients with polyneuropathy. International Journal of Medicine and Psychology. 2019;2(4):73–76.</mixed-citation><mixed-citation xml:lang="ru">Аль Замил М.К. К вопросу о влиянии ТЭНС-терапии на ваш показатели боли у больных полиневропатией // Международный журнал медицины и психологии. 2019. Т. 2, № 4. С. 73–76.7.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Al Zamil M, Kulikova N, Bezrukova O, et al. Effectiveness of transcutaneous electrical neurostimulation for treatment of diabetic distal polyneuropathy. Eur J Neurology. 2019;26(Suppl. 1):729.</mixed-citation><mixed-citation xml:lang="ru">Al Zamil M., Kulikova N., Bezrukova O., et al. Effectiveness of transcutaneous electrical neurostimulation for treatment of diabetic distal polyneuropathy // Eur J Neurology. 2019. Vol. 26, Suppl. 1. P. 729. 2019202 13 27–30 doi: 10.1080/00207454.201</mixed-citation></citation-alternatives></ref></ref-list></back></article>
