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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">686665</article-id><article-id pub-id-type="doi">10.17816/rjpbr686665</article-id><article-id pub-id-type="edn">GERGGJ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original studies</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Fractional laser photothermolysis for early correction of ecchymoses: development of an effective therapeutic protocol</article-title><trans-title-group xml:lang="ru"><trans-title>Фракционный плоскостной фототермолиз в ранней коррекции экхимозов: разработка эффективного терапевтического протокола</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>点阵光热分解技术在早期瘀斑治疗中的应用： 有效治疗方案的制定</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-1759-9995</contrib-id><name-alternatives><name xml:lang="en"><surname>Shamsutdinova</surname><given-names>Diana S.</given-names></name><name xml:lang="ru"><surname>Шамсутдинова</surname><given-names>Диана Стартовна</given-names></name><name xml:lang="zh"><surname>Shamsutdinova</surname><given-names>Diana S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>prokt57@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6550-6940</contrib-id><contrib-id contrib-id-type="spin">7930-2463</contrib-id><name-alternatives><name xml:lang="en"><surname>Ponomarenko</surname><given-names>Inga G.</given-names></name><name xml:lang="ru"><surname>Пономаренко</surname><given-names>Инга Геннадьевна</given-names></name><name xml:lang="zh"><surname>Ponomarenko</surname><given-names>Inga G.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>manga-85@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7853-4473</contrib-id><contrib-id contrib-id-type="spin">8234-7005</contrib-id><name-alternatives><name xml:lang="en"><surname>Ponomarenko</surname><given-names>Gennady N.</given-names></name><name xml:lang="ru"><surname>Пономаренко</surname><given-names>Геннадий Николаевич</given-names></name><name xml:lang="zh"><surname>Ponomarenko</surname><given-names>Gennady N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>ponomarenko.gn@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7143-8411</contrib-id><contrib-id contrib-id-type="spin">5609-9713</contrib-id><name-alternatives><name xml:lang="en"><surname>Platonova</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Платонова</surname><given-names>Анна Вячеславовна</given-names></name><name xml:lang="zh"><surname>Platonova</surname><given-names>Anna V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>platonova1105@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Scientific and Aducational Centre of Medical and Social Expertis and Rehabilitation n. a. G.A. Albrecht</institution></aff><aff><institution xml:lang="ru">Федеральный научно-образовательный центр медико-социальной экспертизы и реабилитации им. Г.А. Альбрехта</institution></aff><aff><institution xml:lang="zh">Federal Scientific and Aducational Centre of Medical and Social Expertis and Rehabilitation n. a. G.A. Albrecht</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">North-Western State Medical University named after I.I. Mechnikov</institution></aff><aff><institution xml:lang="ru">Северо-Западный медицинский университет им. И.И. Мечникова</institution></aff><aff><institution xml:lang="zh">North-Western State Medical University named after I.I. Mechnikov</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Kirov Military Medical Academy</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия им. С.М. Кирова</institution></aff><aff><institution xml:lang="zh">Kirov Military Medical Academy</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-08-27" publication-format="electronic"><day>27</day><month>08</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-11-21" publication-format="electronic"><day>21</day><month>11</month><year>2025</year></pub-date><volume>24</volume><issue>5</issue><issue-title xml:lang="en">Russian Journal of the Physiсal Therapy, Balneotherapy and Rehabilitation</issue-title><issue-title xml:lang="ru">Физиотерапия, бальнеология и реабилитация</issue-title><fpage>383</fpage><lpage>390</lpage><history><date date-type="received" iso-8601-date="2025-07-04"><day>04</day><month>07</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-07-22"><day>22</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-08-27"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/686665">https://rjpbr.com/1681-3456/article/view/686665</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> The correction of ecchymoses remains a pressing issue in dermatology and esthetic medicine. Persistent skin discoloration caused by hemoglobin breakdown (oxyhemoglobin → deoxyhemoglobin → methemoglobin → biliverdin → bilirubin → hemosiderin) leads to psychological discomfort for patients and prolongs rehabilitation after trauma, surgery, or invasive procedures. The limited effectiveness of conventional approaches (topical heparin-containing agents, cold/heat therapy) highlights the need for physical technologies to accelerate hematoma resolution.</p> <p><bold>AIM:<italic> </italic></bold>The work aimed to provide scientific and practical justification for the use of fractional CO₂ laser photothermolysis (10,600 nm) with an optimized L-shaped pulse in patients with ecchymoses and to develop an effective therapeutic protocol.</p> <p><bold>METHODS:<italic> </italic></bold>It was a prospective comparative study of the efficacy and safety of fractional CO₂ laser photothermolysis for ecchymosis correction. The study included 25 patients with post-traumatic or postoperative ecchymoses of 1–5-day duration, divided into the observation group (laser therapy, <italic>n</italic> = 15) and the reference group (conventional therapy, <italic>n</italic> = 10). Parameters: CO₂ laser (10,600 nm) operated in fractional photothermolysis mode with L-shaped pulse, power 6–8 W, microthermal zone density 400–500 dots/cm², 1 pass, pulse duration 500–600 µs. Trends were assessed using photographic documentation, colorimetric scales, and videodermoscopy.</p> <p><bold>RESULTS: </bold>The laser therapy group showed a pronounced positive response: resolution time was reduced by 40%–50% (mean 5 ± 1.8 days vs. 14 ± 2.3 days in the reference group; p &lt; 0.05). Accelerated transition from blue-purple to yellow coloration was observed (by days 3–4), with minimal risk of residual pigmentation. The overall efficacy reached 85% (marked improvement). The safety profile was high: 20% of patients showed mild transient erythema, which resolved within 24 hours.</p> <p><bold>CONCLUSION:<italic> </italic></bold>Fractional CO₂ laser photothermolysis with an L-shaped pulse is an effective method for early correction of ecchymoses, providing targeted ablation of pigmented epidermis and stimulation of lymphatic drainage. Optimized parameters (6–8 W, 400–500 MTZ/cm², 500–600 µs, 1 pass) ensure controlled impact on hemoglobin breakdown products without risk of damaging surrounding intact tissues.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование. </bold>Коррекция экхимозов остаётся актуальной задачей в дерматологии и эстетической медицине. Стойкие изменения цвета кожи, обусловленные распадом гемоглобина (оксигемоглобин → дезоксигемоглобин → метгемоглобин → биливердин → билирубин → гемосидерин), вызывают психологический дискомфорт у пациентов и увеличивают сроки реабилитации после травм, операций или инвазивных процедур. Недостаточная эффективность традиционных методов (местные аппликации гепаринсодержащих средств, холод / тепло) актуализирует поиск физических технологий для ускорения резорбции кровоизлияний.</p> <p><bold>Цель.</bold> Научно-практическое обоснование применения и разработка эффективного терапевтического протокола фракционного фототермолиза CO₂-лазером (10 600 нм) с оптимизированным импульсом L-образной формы у пациентов с экхимозами.</p> <p><bold>Методы.</bold> Проведено проспективное сравнительное исследование эффективности и безопасности методики коррекции экхимозов с помощью фракционного фототермолиза углекислотным лазером. Включены 25 пациентов с посттравматическими / постоперационными экхимозами сроком 1–5 суток, разделённых на группы наблюдения (терапия лазером, <italic>n</italic>=15) и сравнения (традиционная терапия, <italic>n</italic>=10). Применяемые параметры: СО₂-лазер с L-образным импульсным излучением (10 600 нм) в режиме фракционного фототермолиза, мощность 6–8 Вт, плотность микротермальных лечебных зон 400–500 точек/см², 1 стек, длительность импульса 500–600 мкс. Контроль динамики кожного процесса осуществлён с помощью визуальной оценки фотодокументации, цветовой шкалы и видеодерматоскопии.</p> <p><bold>Результаты. </bold>Установлена выраженная положительная динамика в группе лазеротерапии: сокращение сроков разрешения экхимозов на 40–50% (в среднем до 5±1,8 дня против 14±2,3 дня в группе сравнения; <italic>p</italic> &lt;0,05). Отмечены ускорение перехода от сине-багровой к жёлтой окраске (к 3–4-м суткам), минимизация риска остаточной пигментации. Эффективность коррекции составила 85% (значительное улучшение). Установлен высокий профиль безопасности: у 20% пациентов зарегистрирована лёгкая транзиторная эритема, которая купировалась за 24 часа.</p> <p><bold>Заключение. </bold>Терапевтическая технология фракционного СО₂-фототермолиза с L-образным импульсом является эффективным методом ранней коррекции экхимозов за счёт направленной абляции пигментированного эпидермиса и стимуляции лимфодренажа. Оптимизированные параметры (6–8 Вт, 400–500 МТЗ/см², 500–600 мкс, 1 стек) обеспечивают контролируемое воздействие на продукты распада гемоглобина без риска микротермальных повреждений окружающих интактных тканей.</p></trans-abstract><trans-abstract xml:lang="zh"><p><bold>论证：</bold>瘀斑的治疗仍是皮肤病学与美容医学中的重要问题。血红蛋白降解产物（氧合血红蛋白 → 脱氧血红蛋白 → 高铁血红蛋白 → 胆绿素 → 胆红素 → 含铁血黄素）导致的皮肤色素改变会引起患者心理不适，并延长外伤、术后或介入治疗后的康复期。传统疗法（含肝素药膏外用、冷热敷）疗效有限，因此亟需探索物理治疗方法以加快瘀斑消退。</p> <p><bold>目的：</bold>对应用波长为（10 600 nm）、L型脉冲的CO<sub>2</sub>点阵激光进行光热分解治疗瘀斑的科学依据进行论证，并制定有效的治疗方案。</p> <p><bold>材料与方法：</bold>开展前瞻性比较研究，以评估利用二氧化碳点阵激光光热分解技术进行瘀斑矫正方法的疗效与安全性。纳入25例病程1–5天的创伤后或术后瘀斑患者，并将其分为观察组（激光治疗，n=15）和对照组（传统治疗，n=10）治疗参数：在点阵光热分解模式下，采用CO<sub>2</sub>激光，L型脉冲（10 600 nm），功率6–8 W，微热治疗区密度400–500点/cm²，单次叠加，脉冲持续时间500–600 μs。通过照片评估、色彩量表及视频皮肤镜进行动态监测。</p> <p>结果。激光治疗组显示显著改善，瘀斑消退时间缩短40–50%（平均5±1.8天 vs 对照组14±2.3天，p&lt;0.05）。观察到瘀斑颜色加速由青紫色向黄色转变（第3–4天），并且残留色素沉着的风险降低。总体疗效达85%（显著改善）。安全性水平较高：仅20%的患者出现轻度短暂性红斑，并在24小时内自行缓解。</p> <p><bold>结论：</bold>L型脉冲CO<sub>2</sub>点阵光热分解技术可实现对色素沉着表皮的定向消融并促进淋巴引流，是早期瘀斑治疗的有效手段。优化参数（6–8 W，400–500 MTZ/cm²，500–600 μs，单次叠加）可在避免周围完整组织微热损伤的同时，对血红蛋白降解产物实现可控作用。</p></trans-abstract><kwd-group xml:lang="en"><kwd>fractional photothermolysis</kwd><kwd>ecchymosis</kwd><kwd>CO₂ laser</kwd><kwd>L-shaped pulse</kwd><kwd>early correction</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>фракционный фототермолиз</kwd><kwd>экхимоз</kwd><kwd>СО₂-лазер</kwd><kwd>L-образный импульс</kwd><kwd>ранняя коррекция</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>点阵光热分解</kwd><kwd>瘀斑</kwd><kwd>CO2激光</kwd><kwd>L型脉冲</kwd><kwd>早期治疗。</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kryukov VN, Sarkisyan BA, Yankovskiy VE, et al. 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