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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">41699</article-id><article-id pub-id-type="doi">10.18821/1681-3456-2018-17-2-82-85</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">CLINICAL EXPERIENCE OF USING SUBMILISECOND Nd:YAG-LASER RADIATION 1064 NM AND CREAM WITH 1% OF IVERMEKTIN FOR TREATMENT OF PAPULOPUSTULAR FORM OF ROSACEA</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИЧЕСКИЙ ОПЫТ ПРИМЕНЕНИЯ СУБМИЛЛИСЕКУНДНОГО НЕОДИМОВОГО ЛАЗЕРНОГО ИЗЛУЧЕНИЯ 1064 НМ И 1% КРЕМА С ИВЕРМЕКТИНОМ ДЛЯ ЛЕЧЕНИЯ ПАПУЛОПУСТУЛЕЗНОЙ ФОРМЫ РОЗАЦЕА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Novikov</surname><given-names>K. A</given-names></name><name xml:lang="ru"><surname>Новиков</surname><given-names>К. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tamrazova</surname><given-names>Olga Borisovna</given-names></name><name xml:lang="ru"><surname>Тамразова</surname><given-names>Ольга Борисовна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, DSc, Prof., Department of dermatovenereology, Faculty of advanced training of medical workers, Peoples’ Friendship University of Russia, Moscow</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. кафедры дерматовенерологии факультета повышения квалификации медицинских работников ГАОУ ВПО «Российский университет дружбы народов», Москва.</p></bio><email>anait_tamrazova@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bagramova</surname><given-names>G. E</given-names></name><name xml:lang="ru"><surname>Баграмова</surname><given-names>Г. Э</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Savenkov</surname><given-names>V. V</given-names></name><name xml:lang="ru"><surname>Савенков</surname><given-names>В. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal state budgetary institution “National Medical Research Center of Rehabilitation and Balneology”, Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр реабилитации и курортологии» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal state autonomous educational institute of higher education “Peoples’ Friendship University of Russia”</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">State budgetary healthcare institution of Moscow “Moscow scientific-practical center of dermatovenereology and cosmetology” of the Department of healthcare of Moscow”</institution></aff><aff><institution xml:lang="ru">ГБУЗ Москвы «Московский научно-практический центр дерматовенерологии и косметологии Департамента здравоохранения Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2018</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en">VOL 17, NO2 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 17, №2 (2018)</issue-title><fpage>82</fpage><lpage>85</lpage><history><date date-type="received" iso-8601-date="2020-07-23"><day>23</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ООО "Эко-Вектор"</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/41699">https://rjpbr.com/1681-3456/article/view/41699</self-uri><abstract xml:lang="en"><p>Rosacea is a polyethiological disease at the base of it progress is pathologically changed innervation of vessels of the skin of face - angioneurosis and it undergoes several stages of development. Initially, against the background of permanent extension, the vascular wall loses elasticity and the blood plasma penetrates it. Microcirculation disorders lead to hypostasis of tissues. This process leads to change of a biota of the face skin - to the uncontrollable growth of number of a Demodex tick, which is one of the ethyopathogenetics factor of promotion from erythemoteleangiectatic form to papulopustular. Etiological reasonable approach for therapy of papulopustular rosacea is a combination of external and physiotherapeutic methods of therapy. As medicamentous therapy for suppression of excess activity of a Demodex tick and its uncontrollable growth in our research we have taken the cream with 1% of Ivermektin. As a physiotherapeutic influence - the submilisecond Nd:YAG-laser radiation (1064 nm). This radiation influences at expanded vessels, sanifies pustules, moderate temperature increase in a derma to 41-42оС, leads to elimination of puffiness and stage-by-stage restructuring of collagen fibers.</p></abstract><trans-abstract xml:lang="ru"><p>При розацеа изначально на фоне стойкого расширения сосудистая стенка теряет эластичность, сквозь нее пропотевает плазма крови. Наблюдается нарушение микроциркуляции, приводящее к отеку тканей. Данный процесс вызывает изменение биоты кожи лица - неконтролируемый рост количества клещей Demodex, который является одним из этиопатогенетических факторов перехода телеангиэктатической формы розацеа в папулопустулезную. Для медикаментозной терапии, направленной на подавление избыточной активности клеща Demodex и его неконтролируемого роста, в нашем исследовании выбран крем 1% ивермектин, в качестве средства физиотерапевтического воздействия - субмиллисекундный неодимовый лазер 1064 нм. При воздействии данного типа лазерного излучения на кожу отмечено умеренное повышение температуры в дерме (до 41-42оС), приводящее к устранению отечности, разрешению воспалительного процесса, санации пустул и поэтапной реструктуризации коллагеновых волокон, предотвращению развития фиброзного процесса.</p></trans-abstract><kwd-group xml:lang="en"><kwd>laser therapy</kwd><kwd>Rosacea</kwd><kwd>submilisecond Nd:YAG 1064 nm laser</kwd><kwd>vascular damages of skin</kwd><kwd>angioneurosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лазеротерапия</kwd><kwd>розацеа</kwd><kwd>субмиллисекундный неодимовый лазер 1064 нм</kwd><kwd>сосудистые поражения кожи</kwd><kwd>ангионевроз</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Кубанова А.А. (ред.) Клинические рекомендации. Дерматовенерология. 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