Russian Journal of Physiotherapy, Balneology and RehabilitationRussian Journal of Physiotherapy, Balneology and Rehabilitation1681-34562413-2969Eco-Vector4159410.18821/1681-3456-2016-15-4-188-190Research ArticleThe application of photodynamic therapy in the case of insufficient effect of the inhibitors of tumour necrosis factor in the patients with psoriasisPonichE. S-SokolovskyE. VDepartment of Dermatovenerology with a clinic-KruglovaLarisa Sergeevnadoctor med. sci., professor, chief research scientist Moscow Research and Practical Center of Dermatovenerology and Cosmetology Moscow Health Departmentkruglovals@mail.ruBudgetary healthcare facility of Khanty-Mansiysky Autonomous Okrug - Yugra “Khanty-Mansiysky Clinical Dermatovenerological Dispensary”I.P. Pavlov Sankt-Peterburg First State Medical University, Russian Ministry of HealthMoscow Research and Practical Center of Dermatovenerology and Cosmetology Moscow Health Department1508201615418819023072020Copyright © 2016, Eco-Vector2016Psoriasis is a systemic chronic inflammatory disease that affects in the first place the skin and occurs in 1-5% of the general population. The treatment of the patients presenting with this condition implies the application of the topical agent and biological preparations as well as phototherapy and systemic therapy. The patients suffering severe forms of psoriasis in whom systemic immunosuppressive therapy does not yield the desired effect are in need of the treatment with biological preparations. The use of the inhibitors of tumour necrosis factor-alpha produces the insufficient effect even in the case of the positive response, i.e. the psoriasis area and severity index (PASI) of approximately 50 scores (PASI 50). This article presents the results of the application of photodynamic therapy (PDT) for the treatment of 8 patients treated with the inhibitors of tumour necrosis factor-alpha in whom the PASI value of 50 was achieved within the first week after the onset of the treatment. In all these patients, a course of photodynamic therapy consisting of 2-3 procedures made it possible to increase the PASI values to 75 and even 100 scores. It is concluded that the patients showing positive but insufficient effect of biological therapy (PASI 50) need to be prescribed a course of photodynamic treatment in order to enhance the effectiveness of the biological therapeutic factors.psoriasissystemic therapyphotodynamic therapyinhibitors of the tumour necrosis factorпсориазсистемная терапияфотодинамическая терапияблокаторы фактора некроза опухоли[Drew G.S. Psoriasis. Prim. Care. 2000; 23 (2): 385-406.][Nestle F.O., Kaplan D.H., Barker J. Psoriasis. N. Engl. J. Med. 2009; 361: 496-509.][Bremmer S., Van Voorhees A.S., Hsu S. et al. National Psoriasis Foundation. Obesity and psoriasis: from the Medical Board of the National Psoriasis Foundation. J. Am. Acad. Dermatol. 2010; 63: 1058-69.][Потекаев Н.Н., Круглова Л.С. Псориатическая болезнь. M.: Издательство МДФ; 2014.][Tarstedt M., Rosdahl I., Berne B. et al. A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. Acta. Derm. Venereol. (Stockh.). 2005; 85: 1-5.]