The objective of the present study was to evaluate the influence of peloid therapy on the dynamics of clinical and hormonal characteristics of the women presenting with bacterial vaginosis (BV) and accompanying chronic inflammation of the small pelvis organs depending on the initial prolactin (PRL) level. A total of 186 women with this pathology underwent the examination under conditions of a spa and health resort facility for the elucidation of their clinical symptoms and parameters of hormonal regulation. The patients were divided into two groups. Group 1 was comprised of 128 women suffering from BV and having the normal PRL level. Group 2 consisted of 58 women with bacterial vaginosis in combination with hyperprolactinemia (HP). We undertook the dynamic assessment of the clinical and laboratory findings before and after peloid therapy given to the patients of both groups. It was shown that the application of the silt-sulfide therapeutic muds for the treatment of bacterial vaginosis in the women with the normal prolactin level facilitates the formation of positive clinical dynamics, modulates secretion of pituitary hormones, and stimulates the functional activity of both the adrenal glands and the ovaries. Peloid therapy of the women presenting with BV and HP caused the further aggravation of hormonal disbalance as a result of enhancement of the initial PRL level and discoordination of the hypophyseal-ovarian component of the hormonal regulation system; taken together, these effects thereby impaired the effectiveness of the treatment. The results of the study indicate that the level of prolactin can be used as a marker of the effectiveness of the spa and health resort-component of the combined treatment of gynecological diseases. It is concluded that the prescription of such treatment including peloid therapy to the women suffering from these pathologies must take into consideration the initial parameters of hormonal regulation and the presence of hyperprolactinemia.