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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">115273</article-id><article-id pub-id-type="doi">10.17816/rjpbr115273</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Plasma medicine: Prospects and experience of application of low-temperature argon plasma in medical rehabilitation</article-title><trans-title-group xml:lang="ru"><trans-title>Плазменная медицина: перспективы и опыт применения низкотемпературной аргоновой плазмы в медицинской реабилитации</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1103-704X</contrib-id><contrib-id contrib-id-type="spin">6936-0576</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozyreva</surname><given-names>Valeriia O.</given-names></name><name xml:lang="ru"><surname>Козырева</surname><given-names>Валерия Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>kvo03@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-25" publication-format="electronic"><day>25</day><month>12</month><year>2022</year></pub-date><volume>21</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>359</fpage><lpage>367</lpage><history><date date-type="received" iso-8601-date="2022-12-11"><day>11</day><month>12</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-12-25"><day>25</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Эко-Вектор"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/115273">https://rjpbr.com/1681-3456/article/view/115273</self-uri><abstract xml:lang="en"><p>Plasma medicine is a dynamically developing field of science based on the physical and chemical properties of air-plasma flows.</p> <p>Low-temperature plasma is a partially ionized gas with a temperature of about 40ºC, the synergistic interaction of its active substances is a successful method of sterilization, decontamination of wound surfaces, treatment of surgical and burn wounds. Due to the combined action, over the past decades, low-temperature plasma has proven itself in purulent surgery, dermatology, and dentistry, but in addition, it has opened up great prospects in oncology. Possessing the effects of inhibiting inflammatory processes, stimulating regeneration processes, improving microcirculation and tissue metabolism, plasma flows are also used in medical rehabilitation.</p> <p>The review considers the possibilities of using low-temperature plasma in various fields of medicine, as well as the effect of plasma flows on basic cellular processes and various forms of cell death. The experience of using low-temperature argon plasma in the complex rehabilitation of patients with malignant neoplasms is presented.</p> <p>Literature sources from Russian and foreign databases (Elibrary, PubMed) on the topic of low-temperature plasma application in medical practice were analyzed. The analysis showed that plasma medicine is a rapidly developing modern direction, opening up new opportunities in healthcare.</p> <p>Further studies of plasma streams are needed to unlock their full therapeutic potential and fully understand the mechanisms of action.</p></abstract><trans-abstract xml:lang="ru"><p>Плазменная медицина представляет собой динамично развивающуюся сферу науки, основанную на физических и химических свойствах воздушно-плазменных потоков.</p> <p>Низкотемпературная плазма ― это частично ионизированный газ температурой около 40ºC; синергетическое взаимодействие его активных веществ является успешным методом стерилизации, деконтаминации раневых поверхностей, лечения хирургических и ожоговых ран. За последние десятилетия низкотемпературная плазма благодаря её комбинированному действию зарекомендовала себя в гнойной хирургии, дерматологии, стоматологии и, кроме того, открыла большие перспективы в онкологии. Обладая эффектами ингибиции воспалительных процессов, стимуляции процессов регенерации, улучшения микроциркуляции и тканевого обмена, плазменные потоки применяются и в медицинской реабилитации.</p> <p>В обзоре рассматриваются возможности использования низкотемпературной плазмы в различных областях медицины, а также влияние плазменных потоков на основные клеточные процессы и различные формы гибели клеток. Представлен опыт применения низкотемпературной аргоновой плазмы в комплексной реабилитации пациентов со злокачественными новообразованиями.</p> <p>Проанализированы материалы источников литературы из российских и зарубежных баз данных (Elibrary, PubMed) по теме применения низкотемпературной плазмы в медицинской практике. Анализ показал, что плазменная медицина является быстроразвивающимся современным направлением, открывающим новые возможности в здравоохранении.</p> <p>Необходимы дальнейшие изучения плазменных потоков для раскрытия всего их терапевтического потенциала и полного понимания механизмов действия.</p></trans-abstract><kwd-group xml:lang="en"><kwd>medical rehabilitation</kwd><kwd>cold atmospheric plasma</kwd><kwd>mammary cancer</kwd><kwd>radiation reactions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>медицинская реабилитация</kwd><kwd>низкотемпературная плазма</kwd><kwd>рак молочной железы</kwd><kwd>местные лучевые реакции</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Schuster M, Seebauer C, Rutkowski R, et al. Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer. 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