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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">115248</article-id><article-id pub-id-type="doi">10.17816/rjpbr115248</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Laser and phototherapy of rosacea</article-title><trans-title-group xml:lang="ru"><trans-title>Лазерная и фототерапия розацеа</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5995-6689</contrib-id><contrib-id contrib-id-type="spin">3238-9093</contrib-id><name-alternatives><name xml:lang="en"><surname>Matushevskaya</surname><given-names>Yuliya I.</given-names></name><name xml:lang="ru"><surname>Матушевская</surname><given-names>Юлия Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>yuliya-matushevskaya@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Lyubertsy Skin and Venereological Dispensary</institution></aff><aff><institution xml:lang="ru">Люберецкий кожно-венерологический диспансер</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-25" publication-format="electronic"><day>25</day><month>12</month><year>2022</year></pub-date><volume>21</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>349</fpage><lpage>358</lpage><history><date date-type="received" iso-8601-date="2022-12-09"><day>09</day><month>12</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-12-25"><day>25</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Эко-Вектор"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/115248">https://rjpbr.com/1681-3456/article/view/115248</self-uri><abstract xml:lang="en"><p>Rosacea is a non-infectious dermatological disease of middle age, requiring long-term and often lifelong treatment. The onset of the disease begins with minor clinical manifestations such as centrofacial transient erythema or conjunctivitis, which patients often do not consider as a need to consult a doctor.</p> <p>Early therapy prevents the chronization of the process and the development of severe forms, which include papulo-pustular rosacea, ophthalmosacea and phymes.</p> <p>One of the methods of rosacea treatment is physiotherapy, which includes laser light, cryotherapy, darsonvalization, electrophoresis, electrocoagulation, pulse therapy, inductothermy, phototherapy of vascular pathology, and others.</p> <p>This review presents the main mechanisms of laser light action on human skin and systematizes recent data on its use in various forms of rosacea.</p> <p>Despite the moderate success of laser therapy, further research will help to choose more effective treatment protocols for rosacea. The appearance of the first signs of vasodilation in the facial area, especially in people with a family history of rosacea, frequent eye diseases or the presence of fim, requires contacting a dermatologist.</p></abstract><trans-abstract xml:lang="ru"><p>Розацеа является неинфекционным дерматологическим заболеванием среднего возраста, требующим длительного, а иногда пожизненного лечения. Дебют заболевания начинается с незначительных клинических проявлений, в частности центрофациальной транзиторной эритемы или конъюнктивита, что пациентами не рассматривается как необходимость обращения к врачу.</p> <p>Ранняя терапия заболевания предупреждает хронизацию процесса и развитие тяжёлых форм, к которым относятся папулопустулёзная розацеа, офтальморозацеа и фимы.</p> <p>Одним из методов лечения розацеа является физиотерапия, а именно лазерная и криотерапия, дарсонвализация, электрофорез, электрокоагуляция, пульс-терапия, индуктотермия, фототерапия сосудистой патологии и др. В обзоре приведены основные механизмы действия лазерного света на кожу человека, систематизированы данные по его применению при различных формах розацеа.</p> <p>Несмотря на умеренные успехи лазерной терапии, дальнейшие исследования помогут подобрать более эффективные протоколы лечения розацеа. Появление первых признаков расширения сосудов в области лица, особенно у людей с семейной историей розацеа, частыми болезнями глаз или наличием фим, требует обращения к врачу-дерматологу.</p></trans-abstract><kwd-group xml:lang="en"><kwd>rosacea</kwd><kwd>laser therapy</kwd><kwd>cryotherapy</kwd><kwd>phototherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>розацеа</kwd><kwd>лазерная терапия</kwd><kwd>криотерапия</kwd><kwd>фототерапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Yazici AC, Tamer L, Ikizoglu G, et al. GSTM1 and GSTT1 null geno types as possible heritable factors of rosacea. Photodermatol. Photoimmunol Photomed. 2006;22:208–210. doi: 10.1111/j.1600-0781.2006.00220.x</mixed-citation><mixed-citation xml:lang="ru">Yazici A.C., Tamer L., Ikizoglu G., et al. GSTM1 and GSTT1 null genotypes as possible heritable factors of rosacea // Photodermatol Photoimmunol Photomed. 2006. Vol. 22. Р. 208–210. doi: 10.1111/j.1600-0781.2006.00220.x</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Srivastava DS, Jain VK, Verma P, Yadav JP. Polymorphism of glutathione S-transferase M1 and T1 genes and susceptibility to psoriasis disease: A study from North India. Indian J Dermatol Venereol Leprol. 2018;84(1):39–44. doi: 10.4103/ijdvl.IJDVL_1128_16</mixed-citation><mixed-citation xml:lang="ru">Srivastava D.S., Jain V.K., Verma P., Yadav J.P. Polymorphism of glutathione S-transferase M1 and T1 genes and susceptibility to psoriasis disease: A study from North India // Indian J Dermatol Venereol Leprol. 2018. Vol. 84, N 1. Р. 39–44. doi: 10.4103/ijdvl.IJDVL_1128_16</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Guo H, Huang Y, Wu J, et al. Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population. J Gene Med. 2017;19(9-10). doi: 10.1002/jgm.2961</mixed-citation><mixed-citation xml:lang="ru">Guo H., Huang Y., Wu J., et al. Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population // J Gene Med. 2017. Vol. 19, N 9-10. doi: 10.1002/jgm.2961</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Chang AL, Raber I, Xu J, et al. Assessment of the genetic basis of rosacea by genome-wide association study. J Invest Dermatol. 2015;135(6):1548–1555. doi:10.1038/jid.2015.53</mixed-citation><mixed-citation xml:lang="ru">Chang A.L., Raber I., Xu J., et al. Assessment of the genetic basis of rosacea by genome-wide association study // J Invest Dermatol. 2015. Vol. 135, N 6. Р. 1548–1555. doi: 10.1038/jid.2015.53</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Rhodes DA, Reith W, Trowsdale J. Regulation of immunity by butyrophilins. Annu Rev Immunol. 2016;34:151–172. doi: 10.1146/annurev-immunol-041015-055435</mixed-citation><mixed-citation xml:lang="ru">Rhodes D.A., Reith W., Trowsdale J. Regulation of immunity by butyrophilins // Annu Rev Immunol. 2016. Vol. 34. Р. 151–172. doi: 10.1146/annurev-immunol-041015-055435</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Chaperon M, Pacheco Y, Maucort-Boulch D, et al. BTNL2 gene polymorphism and sarcoid uveitis. Br J Ophthalmol. 2019. pii: bjophthalmol-2018-312949. doi: 10.1136/bjophthalmol-2018-312949</mixed-citation><mixed-citation xml:lang="ru">Chaperon M., Pacheco Y., Maucort-Boulch D., et al. BTNL2 gene polymorphism and sarcoid uveitis // Br J Ophthalmol. 2019. pii: bjophthalmol-2018-312949. doi: 10.1136/bjophthalmol-2018-312949</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Tolentino YF, Elia PP, Fogaça HS, et al. Common NOD2/CARD15 and TLR4 polymorphisms are associated with Crohn's disease phenotypes in southeastern Brazilians. Dig Dis Sci. 2016;61(9):2636–2647. doi: 10.1007/s10620-016-4172-8</mixed-citation><mixed-citation xml:lang="ru">Tolentino Y.F., Elia P.P., Fogaça H.S., et al. Common NOD2/CARD15 and TLR4 polymorphisms are associated with Crohn's disease phenotypes in southeastern Brazilians // Dig Dis Sci. 2016. Vol. 61, N 9. Р. 2636–2647. doi: 10.1007/s10620-016-4172-8</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Marrani E, Cimaz R, Lucherini OM, et al. The common NOD2/CARD15 variant P268S in patients with non-infectious uveitis: A cohort study. Pediatr Rheumatol Online J. 2015;13(1):38. doi: 10.1186/s12969-015-0037-5</mixed-citation><mixed-citation xml:lang="ru">Marrani E., Cimaz R., Lucherini O.M., et al. The common NOD2/CARD15 variant P268S in patients with non-infectious uveitis: A cohort study // Pediatr Rheumatol Online J. 2015. Vol. 13, N 1. Р. 38. doi: 10.1186/s12969-015-0037-5</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Angeletti S, Galluzzo S, Santini D, et al. NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population. Hum Immunol. 2009;70(9):729–732. doi: 10.1016/j.humimm.2009.04.026</mixed-citation><mixed-citation xml:lang="ru">Angeletti S., Galluzzo S., Santini D., et al. NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population // Hum Immunol. 2009. Vol. 70, N 9. Р. 729–732. doi: 10.1016/j.humimm.2009.04.026</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Salzer S, Kresse S, Hirai Y, et al. Cathelicidin peptide LL-37 increases UVB-triggered inflammasome activation: Possible implications for rosacea. J Dermatol Sci. 2014;76(3):173–179. doi: 10.1016/j.jdermsci.2014.09.002</mixed-citation><mixed-citation xml:lang="ru">Salzer S., Kresse S., Hirai Y., et al. Cathelicidin peptide LL-37 increases UVB-triggered inflammasome activation: Possible implications for rosacea // J Dermatol Sci. 2014. Vol. 76, N 3. Р. 173–179. doi: 10.1016/j.jdermsci.2014.09.002</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Yamasaki K, Gallo RL. Rosacea as a disease of cathelicidins and skin innate immunity. J Investig Dermatol Symp Proc. 2011;15(1):12–15. doi: 10.1038/jidsymp.2011.4</mixed-citation><mixed-citation xml:lang="ru">Yamasaki K., Gallo R.L. Rosacea as a disease of cathelicidins and skin innate immunity // J Investig Dermatol Symp Proc. 2011. Vol. 15, N 1. Р. 12–15. doi: 10.1038/jidsymp.2011.4</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Gökçınar NB, Karabulut AA, Onaran Z, et al. Elevated tear human neutrophil peptides 1-3, human beta defensin-2 levels and conjunctival cathelicidin LL-37 gene expression in ocular rosacea. Ocul Immunol Inflamm. 2019;27(7):1174–1183. doi: 10.1080/09273948.2018.1504971</mixed-citation><mixed-citation xml:lang="ru">Gökçınar N.B., Karabulut A.A., Onaran Z., et al. Elevated tear human neutrophil peptides 1-3, human beta defensin-2 levels and conjunctival cathelicidin ll-37 gene expression in ocular rosacea // Ocul Immunol Inflamm. 2019. Vol. 27, N 7. Р. 1174–1183. doi: 10.1080/09273948.2018.1504971</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Yamasaki K, Kanada K, Macleod DT, et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol. 2011;131(3):688–697. doi: 10.1038/jid.2010.351</mixed-citation><mixed-citation xml:lang="ru">Yamasaki K., Kanada K., Macleod D.T., et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes // J Invest Dermatol. 2011. Vol. 131, N 3. Р. 688–697. doi: 10.1038/jid.2010.351</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Meyer-Hoffert U, Schröder JM. Epidermal proteases in the pathogenesis of rosacea. J Investig Dermatol Symp Proc. 2011;15(1):16–23. doi: 10.1038/jidsymp.2011.2</mixed-citation><mixed-citation xml:lang="ru">Meyer-Hoffert U., Schröder J.M. Epidermal proteases in the pathogenesis of rosacea // J Investig Dermatol Symp Proc. 2011. Vol. 15, N 1. Р. 16–23. doi: 10.1038/jidsymp.2011.2</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Muto Y, Wang Z, Vanderberghe M, et al. Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea. J Invest Dermatol. 2014;134(11):2728–2736. doi: 10.1038/jid.2014.222</mixed-citation><mixed-citation xml:lang="ru">Muto Y., Wang Z., Vanderberghe M., et al. Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea // J Invest Dermatol. 2014. Vol. 134, N 11. Р. 2728–2736. doi: 10.1038/jid.2014.222</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Zaidi AK, Spaunhurst K, Sprockett D, et al. Characterization of the facial microbiome in twins discordant for rosacea. Exp Dermatol. 2018;27(3):295–298. doi:10.1111/exd.13491</mixed-citation><mixed-citation xml:lang="ru">Zaidi A.K., Spaunhurst K., Sprockett D., et al. Characterization of the facial microbiome in twins discordant for rosacea // Exp Dermatol. 2018. Vol. 27, N 3. Р. 295–298. doi: 10.1111/exd.13491</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Clanner-Engelshofen BM, Bernhard D, Dargatz S, et al. S2k guideline: Rosacea. J Dtsch Dermatol Ges. 2022;20(8):1147–1165. doi: 10.1111/ddg.14849</mixed-citation><mixed-citation xml:lang="ru">Clanner-Engelshofen B.M., Bernhard D., Dargatz S., et al. S2k guideline: Rosacea // J Dtsch Dermatol Ges. 2022. Vol. 20, N 8. Р. 1147–1165. doi: 10.1111/ddg.14849</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Searle T, Ali FR, Carolides S, Al-Niaimi F. Rosacea and diet: What is new in 2021? J Clin Aesthet Dermatol. 2021;14(12):49–54.</mixed-citation><mixed-citation xml:lang="ru">Searle T., Ali F.R., Carolides S., Al-Niaimi F. Rosacea and diet: What is new in 2021? // J Clin Aesthet Dermatol. 2021. Vol. 14, N 12. Р. 49–54.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Silverman HA, Chen A, Kravatz NL, et al. Involvement of neural transient receptor potential channels in peripheral inflammation. Front Immunol. 2020;11:590261. doi: 10.3389/fimmu.2020.590261</mixed-citation><mixed-citation xml:lang="ru">Silverman H.A., Chen A., Kravatz N.L., et al. Involvement of neural transient receptor potential channels in peripheral inflammation // Front Immunol. 2020. Vol. 11. Р. 590261. doi: 10.3389/fimmu.2020.590261</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Ziolkowski N, Kitto SC, Jeong D, et al. Psychosocial and quality of life impact of scars in the surgical, traumatic and burn populations: A scoping review protocol. BMJ Open. 2019;9(6):e021289. doi: 10.1136/bmjopen-2017-021289</mixed-citation><mixed-citation xml:lang="ru">Ziolkowski N., Kitto S.C., Jeong D., et al. Psychosocial and quality of life impact of scars in the surgical, traumatic and burn populations: a scoping review protocol // BMJ Open. 2019. Vol. 9, N 6. Р. e021289. doi: 10.1136/bmjopen-2017-021289</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Anderson RR, Parrish JA. Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220(4596):524–527. doi: 10.1126/science.6836297</mixed-citation><mixed-citation xml:lang="ru">Anderson R.R., Parrish J.A. Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation // Science. 1983. Vol. 220, N 4596. Р. 524–527. doi: 10.1126/science.6836297</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Alam M, Voravutinon N, Warycha M, et al. Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial. J Am Acad Dermatol. 2013;69(3):438–443. doi: 10.1016/j.jaad.2013.04.015</mixed-citation><mixed-citation xml:lang="ru">Alam M., Voravutinon N., Warycha M., et al. Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial // J Am Acad Dermatol. 2013. Vol. 69, N 3. Р. 438–443. doi: 10.1016/j.jaad.2013.04.015</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Campos MA, Sousa AC, Varela P, et al. Comparative effectiveness of purpuragenic 595 nm pulsed dye laser versus sequential emission of 595 nm pulsed dye laser and 1,064 nm Nd:YAG laser: A double-blind randomized controlled study. Acta Dermatovenerol Alp Pannonica Adriat. 2019;28(1):1–5.</mixed-citation><mixed-citation xml:lang="ru">Campos M.A., Sousa A.C., Varela P., et al. Comparative effectiveness of purpuragenic 595 nm pulsed dye laser versus sequential emission of 595 nm pulsed dye laser and 1,064 nm Nd:YAG laser: A double-blind randomized controlled study // Acta Dermatove nerol Alp Pannonica Adriat. 2019. Vol. 28, N 1. Р. 1–5.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Kwon WJ, Park BW, Cho EB, et al. Comparison of efficacy between long-pulsed Nd:YAG laser and pulsed dye laser to treat rosacea-associated nasal telangiectasia. J Cosmet Laser Ther. 2018;20(5):260–264. doi: 10.1080/14764172.2017.1418510</mixed-citation><mixed-citation xml:lang="ru">Kwon W.J., Park B.W., Cho E.B., et al. Comparison of efficacy between long-pulsed Nd:YAG laser and pulsed dye laser to treat rosacea-associated nasal telangiectasia // J Cosmet Laser Ther. 2018. Vol. 20, N 5. Р. 260–264. doi: 10.1080/14764172.2017.1418510</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Salem SA, Abdel Fattah NS, Tantawy SM, et al. Neodymium-yttrium aluminum garnet laser versus pulsed dye laser in erythemato-telangiectatic rosacea: Comparison of clinical efficacy and effect on cutaneous substance (P) expression. J Cosmet Dermatol. 2013;12(3):187–194. doi: 10.1111/jocd.12048</mixed-citation><mixed-citation xml:lang="ru">Salem S.A., Abdel Fattah N.S., Tantawy S.M., et al. Neodymium-yttrium aluminum garnet laser versus pulsed dye laser in erythemato-telangiectatic rosacea: Comparison of clinical efficacy and effect on cutaneous substance (P) expression // J Cosmet Dermatol. 2013. Vol. 12, N 3. Р. 187–194. doi: 10.1111/jocd.12048</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Handler MZ, Bloom BS, Goldberg DJ. IPL vs PDL in treatment of facial erythema: A split-face study. J Cosmet Dermatol. 2017;16(4):450–453. doi: 10.1111/jocd.12365</mixed-citation><mixed-citation xml:lang="ru">Handler M.Z., Bloom B.S., Goldberg D.J. IPL vs PDL in treatment of facial erythema: A split-face study // J Cosmet Dermatol. 2017. Vol. 16, N 4. Р. 450–453. doi: 10.1111/jocd.12365</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Kim BY, Moon HR, Ryu HJ. Comparative efficacy of short-pulsed intense pulsed light and pulsed dye laser to treat rosacea. J Cosmet Laser Ther. 2019;21(5):291–296. doi: 10.1080/14764172.2018.1528371</mixed-citation><mixed-citation xml:lang="ru">Kim B.Y., Moon H.R., Ryu H.J. Comparative efficacy of short-pulsed intense pulsed light and pulsed dye laser to treat rosacea // J Cosmet Laser Ther. 2019. Vol. 21, N 5. Р. 291–296. doi: 10.1080/14764172.2018.1528371</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">Neuhaus IM, Zane LT, Tope WD. Comparative efficacy of nonpurpuragenic pulsed dye laser and intense pulsed light for erythematotelangiectatic rosacea. Dermatol Surg. 2009;35(6):920–928. doi: 10.1111/j.1524-4725.2009.01156.x</mixed-citation><mixed-citation xml:lang="ru">Neuhaus I.M., Zane L.T., Tope W.D. Comparative efficacy of nonpurpuragenic pulsed dye laser and intense pulsed light for erythematotelangiectatic rosacea // Dermatol Surg. 2009. Vol. 35, N 6. Р. 920–928. doi: 10.1111/j.1524-4725.2009.01156.x</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">Nymann P, Hedelund L, Haedersdal M. Long-pulsed dye laser vs. intense pulsed light for the treatment of facial telangiectasias: A randomized controlled trial. J Eur Acad Dermatol Venereol. 2010;24(2):143–146. doi: 10.1111/j.1468-3083.2009.03357.x</mixed-citation><mixed-citation xml:lang="ru">Nymann P., Hedelund L., Haedersdal M. Long-pulsed dye laser vs. intense pulsed light for the treatment of facial telangiectasias: A randomized controlled trial // J Eur Acad Dermatol Venereol. 2010. Vol. 24, N 2. Р. 143–146. doi: 10.1111/j.1468-3083.2009.03357.x</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Tanghetti EA. Split-face randomized treatment of facial telangiectasia comparing pulsed dye laser and an intense pulsed light handpiece. Lasers Surg Med. 2012;44(2):97–102. doi: 10.1002/lsm.21151</mixed-citation><mixed-citation xml:lang="ru">Tanghetti E.A. Split-face randomized treatment of facial telangiectasia comparing pulsed dye laser and an intense pulsed light handpiece // Lasers Surg Med. 2012. Vol. 44, N 2. Р. 97–102. doi: 10.1002/lsm.21151</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">West TB, Alster TS. Comparison of the long-pulse dye (590–595 nm) and KTP (532 nm) lasers in the treatment of facial and leg telangiectasias. Dermatol Surg. 1998;24(2):221–226. doi: 10.1111/j.1524-4725.1998.tb04140.x</mixed-citation><mixed-citation xml:lang="ru">West T.B., Alster T.S. Comparison of the long-pulse dye (590–595 nm) and KTP (532 nm) lasers in the treatment of facial and leg telangiectasias // Dermatol Surg. 1998. Vol. 24, N 2. Р. 221–226. doi: 10.1111/j.1524-4725.1998.tb04140.x</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">Kim SJ, Lee Y, Seo YJ, et al. Comparative efficacy of radiofrequency and pulsed dye laser in the treatment of rosacea. Dermatol Surg. 2017;43(2):204–209. doi: 10.1097/DSS.0000000000000968</mixed-citation><mixed-citation xml:lang="ru">Kim S.J., Lee Y., Seo Y.J., et al. Comparative efficacy of radiofrequency and pulsed dye laser in the treatment of rosacea // Dermatol Surg. 2017. Vol. 43, N 2. Р. 204–209. doi: 10.1097/DSS.0000000000000968</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">Kruglova LS, Kotenko KV, Korchazhkina NB, Turbovskaya SN. Physiotherapy in dermatology. Moscow: GEOTAR-Media; 2016. 304 p. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Круглова Л.С., Котенко К.В., Корчажкина Н.Б., Турбовская С.Н. Физиотерапия в дерматологии. Москва: ГЭОТАР-Медиа, 2016. 304 с.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">Paasch U, Zidane M, Baron JM, et al. S2k guideline: Laser therapy of the skin. J Dtsch Dermatol Ges. 2022;20(9):1248–1267. doi: 10.1111/ddg.14879</mixed-citation><mixed-citation xml:lang="ru">Paasch U., Zidane M., Baron J.M., et al. S2k guideline: Laser therapy of the skin // J Dtsch Dermatol Ges. 2022. Vol. 20, N 9. Р. 1248–1267. doi: 10.1111/ddg.14879</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">Husein-ElAhmed H, Steinhoff M. Light-based therapies in the management of rosacea: A systematic review with meta-ana lysis. Int J Dermatol. 2022;61(2):216–225. doi: 10.1111/ijd.15680</mixed-citation><mixed-citation xml:lang="ru">Husein-ElAhmed H., Steinhoff M. Light-based therapies in the management of rosacea: A systematic review with meta-analysis // Int J Dermatol. 2022. Vol. 61, N 2. Р. 216–225. doi: 10.1111/ijd.15680</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">Luo Y, Luan XL, Zhang JH, et al. Improved telangiectasia and reduced recurrence rate of rosacea after treatment with 540 nm-wavelength intense pulsed light: A prospective randomized controlled trial with a 2-year follow-up. Exp Ther Med. 2020;19(6):3543–3550. doi: 10.3892/etm.2020.8617</mixed-citation><mixed-citation xml:lang="ru">Luo Y., Luan X.L., Zhang J.H., et al. Improved telangiectasia and reduced recurrence rate of rosacea after treatment with 540 nm-wavelength intense pulsed light: A prospective randomized controlled trial with a 2-year follow-up // Exp Ther Med. 2020. Vol. 19, N 6. Р. 3543–3550. doi: 10.3892/etm.2020.8617</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">Liu J, Liu J, Ren Y, et al. Comparative efficacy of intense pulsed light for different erythema associated with rosacea. J Cosmet Laser Ther. 2014;16(6):324–327. doi: 10.3109/14764172.2014.957218</mixed-citation><mixed-citation xml:lang="ru">Liu J., Liu J., Ren Y., et al. Comparative efficacy of intense pulsed light for different erythema associated with rosacea // J Cosmet Laser Ther. 2014. Vol. 16, N 6. Р. 324–327. doi: 10.3109/14764172.2014.957218</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">Sharshunova AA, Kruglova LS, Kotenko KV, Sofinskaya GV. Etiopathogenesis and possibilities of laser therapy of erythematous-telangiectatic subtype of rosacea. Russian journal of the physial therapy, balneotherapy and rehabilitation. 2017;16(6):284–290. doi: 10.18821/1681-3456-2017-16-6-284-290</mixed-citation><mixed-citation xml:lang="ru">Шаршунова А.А., Круглова Л.С., Котенко К.В., Софинская Г.В. Этиопатогенез и возможности лазеротерапии эритематозно-телеангиэктатического подтипа розацеа // Физиотерапия, бальнеология и реабилитация. 2017. Т. 16, № 6. С. 284–290. doi: 10.18821/1681-3456-2017-16-6-284-290</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">Toyos R, Desai NR, Toyos M, Dell SJ. Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study. PLoS One. 2022;17(6):e0270268. doi: 10.1371/journal.pone.0270268</mixed-citation><mixed-citation xml:lang="ru">Toyos R., Desai N.R., Toyos M., Dell S.J. Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study // PLoS One. 2022. Vol. 17, N 6. Р. e0270268. doi: 10.1371/journal.pone.0270268</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">Amaral MT, Haddad A, Nahas FX, et al. Impact of fractional ablative carbon dioxide laser on the treatment of rhinophyma. Aesthet Surg J. 2019;39(4):NP68–NP75. doi: 10.1093/asj/sjy234</mixed-citation><mixed-citation xml:lang="ru">Amaral M.T., Haddad A., Nahas F.X., et al. Impact of fractional ablative carbon dioxide laser on the treatment of rhinophyma // Aesthet Surg J. 2019. Vol. 39, N 4. Р. NP68–NP75. doi: 10.1093/asj/sjy234</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">Kassirer SS, Gotkin RH, Sarnoff DS. Treatment of rhinophyma with fractional CO2 laser resurfacing in a woman of color: Case report and review of the literature. J Drugs Dermatol. 2021;20(7):772–775. doi: 10.36849/JDD.C702</mixed-citation><mixed-citation xml:lang="ru">Kassirer S.S., Gotkin R.H., Sarnoff D.S. Treatment of rhinophyma with fractional CO2 laser resurfacing in a woman of color: Case report and review of the literature // J Drugs Dermatol. 2021. Vol. 20, N 7. Р. 772–775. doi: 10.36849/JDD.C702</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">Bassi A, Campolmi P, Dindelli M, et al. Laser surgery in rhinophyma. G Ital Dermatol Venereol. 2016;151(1):9–16.</mixed-citation><mixed-citation xml:lang="ru">Bassi A., Campolmi P., Dindelli M., et al. Laser surgery in rhinophyma // G Ital Dermatol Venereol. 2016. Vol. 151, N 1. Р. 9–16.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">Badawi A, Osman M, Kassab A. Novel management of rhinophyma by patterned ablative 2940 nm Erbium:YAG laser. Clin Cosmet Investig Dermatol. 2020;13:949–955. doi: 10.2147/CCID.S286847</mixed-citation><mixed-citation xml:lang="ru">Badawi A., Osman M., Kassab A. Novel management of rhinophyma by patterned ablative 2940 nm Erbium:YAG Laser // Clin Cosmet Investig Dermatol. 2020. Vol. 13. Р. 949–955. doi: 10.2147/CCID.S286847</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">Li A, Fang R, Mao X, Sun Q. Photodynamic therapy in the treatment of rosacea: A systematic review. Photodiagnosis Photodyn Ther. 2022;38:102875. doi: 10.1016/j.pdpdt.2022.102875</mixed-citation><mixed-citation xml:lang="ru">Li A., Fang R., Mao X., Sun Q. Photodynamic therapy in the treatment of rosacea: A systematic review // Photodiagnosis Photodyn Ther. 2022. Vol. 38. Р. 102875. doi: 10.1016/j.pdpdt.2022.102875</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">Friedmann DP, Goldman MP, Fabi SG, Guiha I. Multiple sequential light and laser sources to activate aminolevulinic acid for rosacea. J Cosmet Dermatol. 2016;15(4):407–412. doi: 10.1111/jocd.12231</mixed-citation><mixed-citation xml:lang="ru">Friedmann D.P., Goldman M.P., Fabi S.G., Guiha I. Multiple sequential light and laser sources to activate aminolevulinic acid for rosacea // J Cosmet Dermatol. 2016. Vol. 15, N 4. Р. 407–412. doi: 10.1111/jocd.12231</mixed-citation></citation-alternatives></ref></ref-list></back></article>
