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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">115244</article-id><article-id pub-id-type="doi">10.17816/rjpbr115244</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Medical rehabilitation of complications after injections of lipolytics</article-title><trans-title-group xml:lang="ru"><trans-title>Медицинская реабилитация осложнений после инъекций липолитиков</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8813-9132</contrib-id><contrib-id contrib-id-type="spin">9210-8396</contrib-id><name-alternatives><name xml:lang="en"><surname>Ikonnikova</surname><given-names>Evgeniya V.</given-names></name><name xml:lang="ru"><surname>Иконникова</surname><given-names>Евгения Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>evikonnikova@bk.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4281-1947</contrib-id><contrib-id contrib-id-type="spin">5232-0412</contrib-id><name-alternatives><name xml:lang="en"><surname>Manturova</surname><given-names>Natalia E.</given-names></name><name xml:lang="ru"><surname>Мантурова</surname><given-names>Наталья Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>manturovanatalia@bk.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5044-5265</contrib-id><contrib-id contrib-id-type="spin">1107-4372</contrib-id><name-alternatives><name xml:lang="en"><surname>Kruglova</surname><given-names>Larisa S.</given-names></name><name xml:lang="ru"><surname>Круглова</surname><given-names>Лариса Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>kruglovals@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central State Medical Academy of Department of Presidential Affairs</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия Управления делами Президента Российской Федерации</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Institute of Plastic Surgery and Cosmetology</institution></aff><aff><institution xml:lang="ru">Институт пластической хирургии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">The Russian National Research Medical University named after N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-25" publication-format="electronic"><day>25</day><month>12</month><year>2022</year></pub-date><volume>21</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>339</fpage><lpage>348</lpage><history><date date-type="received" iso-8601-date="2022-12-09"><day>09</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Эко-Вектор</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/115244">https://rjpbr.com/1681-3456/article/view/115244</self-uri><abstract xml:lang="en"><p>Lipolytic injections are widely used in cosmetology practice. In most cases, they are used to correct the contours of the body, as well as to reduce the amount of fat deposits in the submental area. Side effects after their use are rare and, as a rule, resolve themselves. However, in the case of the use of non-certified medications, the frequency and severity of complications increase sharply, which requires timely and highly qualified therapy.</p> <p>The article presents overview data concerning the mechanism of action of the main types of lipolytics and their classification, indications and contraindications to lipolytic therapy, reveals the problems of complications that have developed as a result of their use. A description of a clinical case of the development of an inflammatory reaction after injection of a low-quality lipolytic in the area of paint fat bags is presented. The tactics of her therapy are described. This clinical case demonstrates the importance of using certified products, compliance with injection techniques and the correct choice of the patient for this method of cosmetic therapy.</p> <p>The article is of interest to a wide range of specialists (cosmetologists, dermatovenerologists, plastic surgeons, physiotherapists).</p></abstract><trans-abstract xml:lang="ru"><p>Инъекции липолитиков находят широкое применение в косметологической практике. В большинстве случаев они применяются для коррекции контуров тела, а также с целью уменьшения объёма жировых отложений в подподбородочной области. Побочные эффекты после их применения встречаются редко и, как правило, разрешаются самостоятельно. Однако в случае применения несертифицированных препаратов частота и тяжесть осложнений резко возрастают, что требует своевременной и высококвалифицированной терапии.</p> <p>В статье представлены обзорные данные, касающиеся механизма действия основных видов липолитиков и их классификация, показания и противопоказания к липолитической терапии, раскрывается проблематика осложнений, развившихся вследствие их применения. Представляется описание клинического случая развития воспалительной реакции после инъекции липолитика низкого качества в область малярных жировых пакетов. Описывается тактика её терапии. Данный клинический случай демонстрирует важность использования сертифицированной продукции, соблюдения техники инъекций и правильного выбора пациента для проведения данного метода косметологической терапии.</p> <p>Статья представляет интерес для широкого круга специалистов (врачей-косметологов, дерматовенерологов, пластических хирургов, физиотерапевтов).</p></trans-abstract><kwd-group xml:lang="en"><kwd>phosphatidylcholine</kwd><kwd>sodium deoxycholate</kwd><kwd>injectable lipolysis</kwd><kwd>lipolytics</kwd><kwd>complications of lipolytics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>фосфатидилхолин</kwd><kwd>дезоксихолат натрия</kwd><kwd>инъекционный липолиз</kwd><kwd>липолитики</kwd><kwd>осложнения липолитиков</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Duncan DI, Palmer M. Fat reduction using phosphatidylcholine/sodium deoxycholate injections: Standard of practice. Aesthetic Plast Surg. 2008;32(6):858–872. doi: 10.1007/s00266-008-9188-9</mixed-citation><mixed-citation xml:lang="ru">Duncan D.I., Palmer M. Fat reduction using phosphatidylcholine/sodium deoxycholate injections: Standard of practice // Aesthetic Plast Surg. 2008. Vol. 32, N 6. Р. 858–872. doi: 10.1007/s00266-008-9188-9</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Shirshakova MA. Mesotherapeutic correction of edematous-fibrous panniculopathy (cellulite) and local fat deposits. Plastic Sur Cosmetology. 2010;(3):445–449. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Ширшакова М.А. Мезотерапевтическая коррекция эдематозно-фиброзной панникулопатии (целлюлита) и локальных жировых отложений // Пластическая хирургия и косметология. 2010. № 3. С. 445–449.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Shirshakova MA. Mesotherapy of cellulite: some practical recommendations. Injection Methods Cosmetology. 2011;(2):26–29. (In Russ).</mixed-citation><mixed-citation xml:lang="ru">Ширшакова М.А. Мезотерапия целлюлита: некоторые практические рекомендации // Инъекционные методы в косметологии. 2011. № 2. С. 26–29.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: Historical clarification and review. Dermatol Surg. 2006;32(4):465–480. doi: 10.1111/j.1524-4725.2006.32100</mixed-citation><mixed-citation xml:lang="ru">Rotunda A.M., Kolodney M.S. Mesotherapy and phosphatidylcholine injections: Historical clarification and review // Dermatol Surg. 2006. Vol. 32, N 4. Р. 465–480. doi: 10.1111/j.1524-4725.2006.32100</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Lijnen P, Echevaria-Vazquez D, Petrov V. Influence of cholesterol-lowering on plasma membrane lipids and function. Methods Find Exp Clin Pharmacol. 1996;18(2):123–136.</mixed-citation><mixed-citation xml:lang="ru">Lijnen P., Echevaria-Vazquez D., Petrov V. Influence of cholesterol-lowering on plasma membrane lipids and function // Methods Find Exp Clin Pharmacol. 1996. Vol. 18, N 2. Р. 123–136.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Lieber CS, Robins SJ, Li J, et al. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology. 1994;106(1):152–159. doi: 10.1016/s0016-5085(94)95023-7</mixed-citation><mixed-citation xml:lang="ru">Lieber C.S., Robins S.J., Li J., et al. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon // Gastroenterology. 1994. Vol. 106, N 1. Р. 152–159. doi: 10.1016/s0016-5085(94)95023-7</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo-controlled trial of high-dose lecithin in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 1985;48(8):736–742. doi: 10.1136/jnnp.48.8.736</mixed-citation><mixed-citation xml:lang="ru">Little A., Levy R., Chuaqui-Kidd P., Hand D. A double-blind, placebo-controlled trial of high-dose lecithin in Alzheimer’s disease // J Neurol Neurosurg Psychiatry. 1985. Vol. 48, N 8. Р. 736–742. doi: 10.1136/jnnp.48.8.736</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Cohen BM, Lipinski JF, Altesman RI. Lecithin in the treatment of mania: Double-blind, placebo-controlled trials. Am J Psychiatry. 1982;139(9):1162–1164. doi: 10.1176/ajp.139.9.1162</mixed-citation><mixed-citation xml:lang="ru">Cohen B.M., Lipinski J.F., Altesman R.I. Lecithin in the treatment of mania: Double-blind, placebo-controlled trials // Am J Psychiatry. 1982. Vol. 139, N 9. Р. 1162–1164. doi: 10.1176/ajp.139.9.1162</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Bobkova VI, Lokshina LI, Korsunskii VN, Tananova GV. Metabolic effect of lipostabil-forte. Kardiologiia. 1989;29(10):57–60.</mixed-citation><mixed-citation xml:lang="ru">Bobkova V.I., Lokshina L.I., Korsunskii V.N., Tananova G.V. Metabolic effect of lipostabil-forte // Kardiologiia. 1989. Vol. 29, N 10. Р. 57–60.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Rittes PG, Rites C. Treatment of aging neck with Lipostabil Endovena. J Drugs Dermatol 2009;8(10):937–939.</mixed-citation><mixed-citation xml:lang="ru">Rittes P.G., Rites C. Treatment of aging neck with Lipostabil Endovena // J Drugs Dermatol. 2009. Vol. 8, N 10. Р. 937–939.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Heinrich KG. Efficacy of injections of phosphatidylcholine into fat deposits: A non-surgical alternative to liposuction in body-contouring. Indian Journal of Plastic Surgery. 2005;38(2):119–122. doi: 10.4103/0970-0358.19779</mixed-citation><mixed-citation xml:lang="ru">Heinrich K.G. Efficacy of injections of phosphatidylcholine into fat deposits: A non-surgical alternative to liposuction in body-contouring // Indian J Plastic Sur. 2005. Vol. 38, N 2. Р. 119–122. doi: 10.4103/0970-0358.19779</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol. 2003;2(5):511–518.</mixed-citation><mixed-citation xml:lang="ru">Hexsel D., Serra M., Mazzuco R., et al. Phosphatidylcholine in the treatment of localized fat // J Drugs Dermatol. 2003. Vol. 2, N 5. Р. 511–518.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Rittes PG. The lipodissolve technique: Clinical experience. Clin Plast Surg 2009;36(2):215–221. doi: 10.1016/j.cps.2008.11.003</mixed-citation><mixed-citation xml:lang="ru">Rittes P.G. The lipodissolve technique: Clinical experience // Clin Plast Surg 2009. Vol. 36, N 2. Р. 215–221. doi: 10.1016/j.cps.2008.11.003</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Hasengschwandtner F. Injection lipolysis for effective reduction of localized fat in place of minor surgical lipoplasty. Aesthet Surg J 2006;26(2):125–130. doi: 10.1016/j.asj.2006.01.008</mixed-citation><mixed-citation xml:lang="ru">Hasengschwandtner F. Injection lipolysis for effective reduction of localized fat in place of minor surgical lipoplasty // Aesthet Surg J. 2006. Vol. 26, N 2. Р. 125–130. doi: 10.1016/j.asj.2006.01.008</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Peckitt N. Evidence based practice: phosphatidylcholine. A review of evidence for the mode of action in injection lipolysis. Jeremy Mills Publishing: Yorkshire, UK; 2005. 154 p.</mixed-citation><mixed-citation xml:lang="ru">Peckitt N. Evidence based practice: Phosphatidylcholine. A review of evidence for the mode of action in injection lipolysis. Jeremy Mills Publishing: Yorkshire, UK, 2005. 154 p.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Duncan D, Rotunda AM. Injectable therapies for localized fat loss: State of the art. Clin Plast Surg. 2011;38(3):489–501. doi: 10.1016/j.cps.2011.02.005</mixed-citation><mixed-citation xml:lang="ru">Duncan D., Rotunda A.M. Injectable therapies for localized fat loss: State of the art // Clin Plast Surg. 2011. Vol. 38, N 3. Р. 489–501. doi: 10.1016/j.cps.2011.02.005</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatol Surg. 2004;30(7):1001–1008. doi: 10.1111/j.1524-4725.2004.30305</mixed-citation><mixed-citation xml:lang="ru">Rotunda A.M., Suzuki H., Moy R.L., Kolodney M.S. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution // Dermatol Surg. 2004. Vol. 30, N 7. Р. 1001–1008. doi: 10.1111/j.1524-4725.2004.30305</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. J Cosmet Dermatol. 2005;4(4):308–313. doi: 10.1111/j.1473-2165.2005.00211</mixed-citation><mixed-citation xml:lang="ru">Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis // J Cosmet Dermatol. 2005. Vol. 4, N 4. Р. 308–313. doi: 10.1111/j.1473-2165.2005.00211</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Rose PT, Morgan M. Histological changes associated with mesotherapy for fat dissolution. J Cosmet Laser Ther. 2005;7(1):17–19. doi: 10.1080/14764170510037743</mixed-citation><mixed-citation xml:lang="ru">Rose P.T., Morgan M. Histological changes associated with mesotherapy for fat dissolution // J Cosmet Laser Ther. 2005. Vol. 7, N 1. Р. 17–19. doi: 10.1080/14764170510037743</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Palumbo P, Melchiorre E, La Torre C, et al. Effects of phosphatidylcholine and sodium deoxycholate on human primary adipocytes and fresh human adipose tissue. Int J Immunopathol Pharmacol. 2010;23(2):481–489. doi: 10.1177/039463201002300210</mixed-citation><mixed-citation xml:lang="ru">Palumbo P., Melchiorre E., La Torre C., et al. Effects of phosphatidylcholine and sodium deoxycholate on human primary adipocytes and fresh human adipose tissue // Int J Immunopathol Pharmacol. 2010. Vol. 23, N 2. Р. 481–489. doi: 10.1177/039463201002300210</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Duncan D, Rubin JP, Golitz L, et al. Refinement of technique in injection lipolysis based on scientific studies and clinical eva luation. Clin Plast Surg. 2009;36(2):195–209. doi: 10.1016/j.cps.2008.11.001</mixed-citation><mixed-citation xml:lang="ru">Duncan D., Rubin J.P., Golitz L., et al. Refinement of technique in injection lipolysis based on scientific studies and clinical eva luation // Clin Plast Surg. 2009. Vol. 36, N 2. Р. 195–209. doi: 10.1016/j.cps.2008.11.001</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Salti G, Ghersetich I, Tantussi F, et al. Phosphatidylcholine and sodium deoxycholate in the treatment of localized fat: A double-blind, randomized study. Dermatol Surg. 2008;34(2):60–66; discussion 66. doi: 10.1111/j.1524-4725.2007.34009</mixed-citation><mixed-citation xml:lang="ru">Salti G., Ghersetich I., Tantussi F., et al. Phosphatidylcholine and sodium deoxycholate in the treatment of localized fat: A double-blind, randomized study // Dermatol Surg. 2008. Vol. 34, N 2. Р. 60–66; discussion 66. doi: 10.1111/j.1524-4725.2007.34009</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Rotunda AM, Ablon G, Kolodney MS. Lipomas treated with subcutaneous deoxycholate injections. J Am Acad Dermatol. 2005;53(6):973–978. doi: 10.1016/j.jaad.2005.07.068</mixed-citation><mixed-citation xml:lang="ru">Rotunda A.M., Ablon G., Kolodney M.S. Lipomas treated with subcutaneous deoxycholate injections // J Am Acad Dermatol. 2005. Vol. 53, N 6. Р. 973–978. doi: 10.1016/j.jaad.2005.07.068</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Yagima Odo ME, Cuce LC, Odo LM, Natrielli A. Action of sodium deoxycholate on subcutaneous human tissue: Local and syste mic effects. Dermatol Surg. 2007;33(2):178–188; discussion 88–89. doi: 10.1111/j.1524-4725.2006.33036</mixed-citation><mixed-citation xml:lang="ru">Yagima Odo M.E., Cuce L.C., Odo L.M., Natrielli A. Action of sodium deoxycholate on subcutaneous human tissue: Local and systemic effects // Dermatol Surg. 2007. Vol. 33, N 2. Р. 178–188; discussion 88–89. doi: 10.1111/j.1524-4725.2006.33036</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">American Society for Aesthetic Plastic Surgery [Internet]. National plastic surgery statistics: Cosmetic and reconstruction procedure trends. New York: American Society for Aesthetic Plastic Surgery. Available from: http://www.plasticsurgery.org/public_education/statistical_trends.cf. Accessed: 15.07.2022.</mixed-citation><mixed-citation xml:lang="ru">American Society for Aesthetic Plastic Surgery [интернет]. National plastic surgery statistics: Cosmetic and reconstruction procedure trends. New York: American Society for Aesthetic Plastic Surgery. Режим доступа: http://www.plasticsurgery.org/public_education/statistical_trends.cf. Дата обращения: 15.07.2022.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Vedamurthy M. Mesotherapy. Indian J Dermatol Venereol Leprol. 2007;73(1):60–62. doi: 10.4103/0378-6323.30661</mixed-citation><mixed-citation xml:lang="ru">Vedamurthy M. Mesotherapy // Indian J Dermatol Venereol Leprol. 2007. Vol. 73, N 1. Р. 60–62. doi: 10.4103/0378-6323.30661</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Gupta A, Lobocki C, Singh S, et al. Actions and comparative efficacy of phosphatidylcholine formulation and isolated sodium deoxycholate for different cell types. Aesthetic Plast Surg. 2009;33(3):346–352. doi: 10.1007/s00266-008-9301-0</mixed-citation><mixed-citation xml:lang="ru">Gupta A., Lobocki C., Singh S., et al. Actions and comparative efficacy of phosphatidylcholine formulation and isolated sodium deoxycholate for different cell types // Aesthetic Plast Surg. 2009. Vol. 33, N 3. Р. 346–352. doi: 10.1007/s00266-008-9301-0</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">Duncan D, Hasengschwandtner F. Lipodissolve for subcutaneous fat reduction and skin retraction. Aesthetic Surgery Journal. 2005;25(5):530–543. doi: 10.1016/j.asj.2005.07.009</mixed-citation><mixed-citation xml:lang="ru">Duncan D., Hasengschwandtner F. Lipodissolve for subcutaneous fat reduction and skin retraction // Aesthetic Surgery Journal. 2005. Vol. 25, N 5. Р. 530–543. doi: 10.1016/j.asj.2005.07.009</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">El-Gowelli HM, El Sabaa B, Yosry E, El-Saghir H. Histopatholo gical and ultra-structural characterization of local neuromuscular damage induced by repeated phosphatidylcholine/deoxycholate injection. Exp Toxicol Pathol. 2016;68(1):39–46. doi: 10.1016/j.etp.2015.09.006</mixed-citation><mixed-citation xml:lang="ru">El-Gowelli H.M., El Sabaa B., Yosry E., El-Saghir H. Histopatholo gical and ultra-structural characterization of local neuromuscular damage induced by repeated phosphatidylcholine/deoxycholate injection // Exp Toxicol Pathol. 2016. Vol. 68, N 1. Р. 39–46. doi: 10.1016/j.etp.2015.09.006</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Blandford AD, Ansari W, Young JM, et al. Deoxycholic acid and the marginal mandibular nerve: a cadaver study. Aesthetic Plast Surg. 2018;42(5):1394–1398. doi: 10.1007/s00266-018-1164-4</mixed-citation><mixed-citation xml:lang="ru">Blandford A.D., Ansari W., Young J.M., et al. Deoxycholic acid and the marginal mandibular nerve: A cadaver study // Aesthetic Plast Surg. 2018. Vol. 42, N 5. Р. 1394–1398. doi: 10.1007/s00266-018-1164-4</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">Sorenson E, Chesnut C. Marginal mandibular versus pseudo-marginal mandibular nerve injury with submandibular deoxycholic acid injection. Dermatol Surg. 2018;44(5):733–735. doi: 10.1097/DSS.0000000000001291</mixed-citation><mixed-citation xml:lang="ru">Sorenson E., Chesnut C. Marginal mandibular versus pseudo-marginal mandibular nerve injury with submandibular deoxycholic acid injection // Dermatol Surg. 2018. Vol. 44, N 5. Р. 733–735. doi: 10.1097/DSS.0000000000001291</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">Fagien S, Mcchesney P, Subramanian M, et al. Prevention and management of injection-related adverse effects in facial aesthetics: Considerations for ATX-101 (deoxycholic acid injection) treatment. Dermatol Surg. 2016;42(1):300–304. doi: 10.1097/DSS.0000000000000898</mixed-citation><mixed-citation xml:lang="ru">Fagien S., Mcchesney P., Subramanian M., et al. Prevention and management of injection-related adverse effects in facial aesthetics: considerations for ATX-101 (deoxycholic acid injection) treatment // Dermatol Surg. 2016. Vol. 42, N 1. Р. 300–304. doi: 10.1097/DSS.0000000000000898</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">Jones DH, Carruthers J, Joseph JH, et al. REFINE-1, a multicenter, randomized, double-blind, placebo-controlled, phase 3 trial with ATX-101, an injectable drug for submental fat reduction. Dermatol Surg. 2016;42(1):38–49. doi: 10.1097/DSS.0000000000000578</mixed-citation><mixed-citation xml:lang="ru">Jones D.H., Carruthers J., Joseph J.H., et al. REFINE-1, a multicenter, randomized, double-blind, placebo-controlled, phase 3 trial with ATX-101, an injectable drug for submental fat reduction // Dermatol Surg. 2016. Vol. 42, N 1. Р. 38–49. doi: 10.1097/DSS.0000000000000578</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">Souyoul S, Gioe O, Emerson A, Hoope D. Alopecia after injection of ATX-101 for reduction of submental fat. Сase Reports JAAD Case Rep. 2017;3(3):250–252. doi: 10.1016/j.jdcr.2017.02.021</mixed-citation><mixed-citation xml:lang="ru">Souyoul S., Gioe O., Emerson A., Hoope D. Alopecia after injection of ATX-101 for reduction of submental fat // Сase Reports JAAD Case Rep. 2017. Vol. 3, N 3. Р. 250–252. doi: 10.1016/j.jdcr.2017.02.021</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">Metzger KC, Crowley EL, Kadlubowska D, et al. Uncommon adverse effects of deoxycholic acid injection for submental fullness: Beyond the clinical trials. J Cutan Med Surg. 2020;24(6):619–624. doi: 10.1177/1203475420943270</mixed-citation><mixed-citation xml:lang="ru">Metzger K.C., Crowley E.L., Kadlubowska D., et al. Uncommon adverse effects of deoxycholic acid injection for submental fullness: Beyond the clinical trials // J Cutan Med Surg. 2020. Vol. 24, N 6. Р. 619–624. doi: 10.1177/1203475420943270</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">Prantl L, Gehmert S, Brébant V, et al. Lipolytic effects of nano particle sized polyenylphosphatidylcholine on adipose tissue: First promising in vitro and in vivo results. Hoesl Lin Hemorheol Microcirc. 2020;75(2):189–199. doi: 10.3233/CH-190715</mixed-citation><mixed-citation xml:lang="ru">Prantl L., Gehmert S., Brébant V., et al. Lipolytic effects of nano particle sized polyenylphosphatidylcholine on adipose tissue: First promising in vitro and in vivo results // Hoesl Lin Hemorheol Microcirc. 2020. Vol. 75, N 2. Р. 189–199. doi: 10.3233/CH-190715</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">Urbani CE. Urticarial reaction to ethylenediamine in aminophylline following mesotherapy. Contact Dermatitis. 1994;31(3):198–199. doi: 10.1111/j.1600-0536.1994.tb01975.x</mixed-citation><mixed-citation xml:lang="ru">Urbani C.E. Urticarial reaction to ethylenediamine in aminophylline following mesotherapy // Contact Dermatitis. 1994. Vol. 31, N 3. Р. 198–199. doi: 10.1111/j.1600-0536.1994.tb01975.x</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">Vikbjerg AF, Mu H, Xu X. Lipase-catalyzed acyl exchange of soybean phosphatidylcholine in n-Hexane: A critical evaluation of both acyl incorporation and product recovery. Biotechnol Prog. 2005;21(2):397–404. doi: 10.1021/bp049633y</mixed-citation><mixed-citation xml:lang="ru">Vikbjerg A.F., Mu H., Xu X. Lipase-catalyzed acyl exchange of soybean phosphatidylcholine in n-Hexane: A critical evaluation of both acyl incorporation and product recovery // Biotechnol Prog. 2005. Vol. 21, N 2. Р. 397–404. doi: 10.1021/bp049633y</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">Duncan DI, Chubaty R. Clinical safety data and standards of practice for injection lipolysis: A retrospective study. Aesthet Surg J. 2006;26(5):575–585. doi: 10.1016/j.asj.2006.08.006</mixed-citation><mixed-citation xml:lang="ru">Duncan D.I., Chubaty R. Clinical safety data and standards of practice for injection lipolysis: A retrospective study // Aesthet Surg J. 2006. Vol. 26, N 5. Р. 575–585. doi: 10.1016/j.asj.2006.08.006</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">Rosina P, Chieregalo C, Miccolis D, D'Onghia FS. Psoriasis and side-effects of mesotherapy. Int J Dermatol. 2001;40(9):581–583. doi: 10.1046/j.1365-4362.2001.01248-3.x</mixed-citation><mixed-citation xml:lang="ru">Rosina P., Chieregalo C., Miccolis D., D'Onghia F.S. Psoriasis and side-effects of mesotherapy // Int J Dermatol. 2001. Vol. 40, N 9. Р. 581–583. doi: 10.1046/j.1365-4362.2001.01248-3.x</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">Gokdemir G, Kucukunal A, Sakiz D. Cutaneous granulomatous reaction from mesotherapy. Dermatol Surg. 2009;35(2):291–293. doi: 10.1111/j.1524-4725.2008.01053.x</mixed-citation><mixed-citation xml:lang="ru">Gokdemir G., Kucukunal A., Sakiz D. Cutaneous granulomatous reaction from mesotherapy // Dermatol Surg. 2009. Vol. 35, N 2. Р. 291–293. doi: 10.1111/j.1524-4725.2008.01053.x</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">Davis MD, Wright TI, Shehan JM. A complication of mesotherapy: Noninfectious granulomatous panniculitis. Arch Dermatol. 2008;144(6):808–809. doi: 10.1001/archderm.144.6.808</mixed-citation><mixed-citation xml:lang="ru">Davis M.D., Wright T.I., Shehan J.M. A complication of mesotherapy: Noninfectious granulomatous panniculitis // Arch Dermatol. 2008. Vol. 144, N 6. Р. 808–809. doi: 10.1001/archderm.144.6.808</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">Tan J, Rao B. Mesotherapy-induced panniculitis treated with dapsone: Case report and review of reported adverse effects of mesotherapy. J Cutan Med Surg. 2006;10(2):92–95. doi: 10.2310/7750.2006.00013</mixed-citation><mixed-citation xml:lang="ru">Tan J., Rao B. Mesotherapy-induced panniculitis treated with dapsone: Case report and review of reported adverse effects of mesotherapy // J Cutan Med Surg. 2006. Vol. 10, N 2. Р. 92–95. doi: 10.2310/7750.2006.00013</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">Kutlubay Z, Gokalp H, Ince U, Engin B. Cutaneous foreign body granulomas associated with lipolytic cocktail: Who is the ene my, mesotherapy or drugs injected? J Cosmet Laser Ther. 2017;19(5):310–312. doi: 10.1080/14764172.2017.1303167</mixed-citation><mixed-citation xml:lang="ru">Kutlubay Z., Gokalp H., Ince U., Engin B. Cutaneous foreign body granulomas associated with lipolytic cocktail: Who is the enemy, mesotherapy or drugs injected? // J Cosmet Laser Ther. 2017. Vol. 19, N 5. Р. 310–312. doi: 10.1080/14764172.2017.1303167</mixed-citation></citation-alternatives></ref></ref-list></back></article>
