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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Physiotherapy, Balneology and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиотерапия, бальнеология и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1681-3456</issn><issn publication-format="electronic">2413-2969</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">108027</article-id><article-id pub-id-type="doi">10.17816/rjpbr108027</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hyaluronidase: efficacy and safety of use in cosmetology</article-title><trans-title-group xml:lang="ru"><trans-title>Гиалуронидаза: эффективность и безопасность применения в косметологии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8813-9132</contrib-id><contrib-id contrib-id-type="spin">9210-8396</contrib-id><name-alternatives><name xml:lang="en"><surname>Ikonnikova</surname><given-names>Evgeniya V.</given-names></name><name xml:lang="ru"><surname>Иконникова</surname><given-names>Евгения Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Associate Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>evikonnikova@bk.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1770-0439</contrib-id><name-alternatives><name xml:lang="en"><surname>Golanova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Голанова</surname><given-names>Ольга Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>evikonnikova@bk.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5044-5265</contrib-id><contrib-id contrib-id-type="spin">1107-4372</contrib-id><name-alternatives><name xml:lang="en"><surname>Kruglova</surname><given-names>Larisa S.</given-names></name><name xml:lang="ru"><surname>Круглова</surname><given-names>Лариса Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>kruglovals@mail.ru</email><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central State Medical Academy General Management Department of the President of the Russian Federation</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия Управления делами Президента Российской Федерации</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Institute of Plastic Surgery and Cosmetology</institution></aff><aff><institution xml:lang="ru">Институт пластической хирургии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Delite-Lancet, LLC, Lancet-Center Clinic</institution></aff><aff><institution xml:lang="ru">ООО «Делайт-Ланцетъ», клиника «Ланцетъ-Центр»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Central State Medical Academy General Management Department of the President of the Russian Federation</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия Управления делами Президента Российской Федерации</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2021</year></pub-date><volume>20</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>511</fpage><lpage>516</lpage><history><date date-type="received" iso-8601-date="2022-05-18"><day>18</day><month>05</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-06-08"><day>08</day><month>06</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Ikonnikova E.V., Golanova O.A., Kruglova L.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Иконникова Е.В., Голанова О.А., Круглова Л.С.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Ikonnikova E.V., Golanova O.A., Kruglova L.S.</copyright-holder><copyright-holder xml:lang="ru">Иконникова Е.В., Голанова О.А., Круглова Л.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2024-09-15"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjpbr.com/1681-3456/article/view/108027">https://rjpbr.com/1681-3456/article/view/108027</self-uri><abstract xml:lang="en"><p>With an increase in requests for the correction of aesthetic imperfections with dermal fillers based on hyaluronic acid, cases of adverse events and complications have become more frequent. Hyaluronic acid in the form of a dermal filler is one of the most popular procedures in aesthetic medicine and has a high safety profile. Despite the fact that hyaluronic acid is an integral part of the extracellular matrix, fillers based on it can also cause complications. The use of an antidote in the form of hyaluronidase allows you to correct possible adverse reactions such as hypercorrection, the Tyndall effect, the formation of granulomas, and the development of tissue ischemia. Hyaluronidase is widely used in all branches of medicine, including the treatment of adhesions in the body, is used in in vitro fertilization, improves the absorption of drugs into the lesion in the treatment of cancer patients, and is also successfully used in the treatment of dermatological patients. In cosmetology, the use of enzyme helps to cope with such severe phenomena as tissue ischemia due to intravascular occlusion by the drug. And the use of ultrasound diagnostics makes it possible to correct adverse events using the enzyme strictly in the focus of the filler, thereby improving the quality of the treatment.</p></abstract><trans-abstract xml:lang="ru"><p>С увеличением запросов на коррекцию эстетических недостатков дермальными наполнителями на основе гиалуроновой кислоты участились случаи нежелательных явлений и осложнений. Гиалуроновая кислота в виде дермального наполнителя является одним из наиболее популярных в эстетической медицине инъекционных средств и обладает высоким профилем безопасности. Несмотря на то что она является неотъемлемой частью внеклеточного матрикса, филлеры на её основе также могут вызвать осложнения. Применение антидота в виде гиалуронидазы позволяет скорректировать возможные нежелательные реакции, такие как гиперкоррекция, эффект Тиндаля, формирование гранулём, а также развитие ишемии тканей. Гиалуронидаза широко используется во всех отраслях медицины, включая лечение спаечных процессов в организме, при экстракорпоральном оплодотворении, улучшает всасывание лекарственных препаратов в очаге поражения при лечении онкобольных, а также с успехом применяется в лечении дерматологических пациентов. В косметологии применение фермента помогает справиться с такими тяжёлыми явлениями, как ишемия тканей вследствие внутрисосудистой окклюзии препаратом. Использование ультразвуковой диагностики позволяет провести коррекцию нежелательных явлений с применением фермента строго в очаге наполнителя, тем самым повышая качество проводимого лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hyaluronidase</kwd><kwd>hyaluronic acid</kwd><kwd>correction of complications</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гиалуронидаза</kwd><kwd>гиалуроновая кислота</kwd><kwd>коррекция осложнений</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Girish KS, Kemparaju K, Nagaraju S, Vishwanath BS. Hyaluronidase inhibitors: a biological and therapeutic perspective. Curr Med Chem. 2009;16(18):2261–2288. doi: 10.2174/092986709788453078</mixed-citation><mixed-citation xml:lang="ru">Girish K.S., Kemparaju K., Nagaraju S., Vishwanath B.S. Hyaluronidase inhibitors: a biological and therapeutic perspective // Curr Med Chem. 2009. 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