Enviar artigo por via de e-mail A STUDY OF ATROPINE INFLUENCE ON ACHE AND BCHE GENES EXPRESSION IN RATS EXPOSED TO MALATHION POISONING
- Autores: Babkin A.V.1, Berdinskih I.S.1, Osechkina N.S.2, Nazarov G.V.1, Yudin M.A.1, Bykov V.N.1
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Afiliações:
- Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
- Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency of Russia
- Edição: Nº 6 (2015)
- Páginas: 22-26
- Seção: Articles
- ##submission.datePublished##: 04.12.2015
- URL: https://rjpbr.com/0869-7922/article/view/641358
- DOI: https://doi.org/10.15690/vramn521
- ID: 641358
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Resumo
Levels of expression of Ache and Bche genes in tissue samples were investigated in rats exposed to malathion in dose of 1 LD50 and following atropine treatment. Malathion poisoning causes statistically significant decrease in levels of expression of Ache and Bche genes in brain and liver. The decrease of expression of these genes was greater than 50% and remained at this level during 14 days. It was shown that atropine treatment prevents decrease in Ache gene expression in brain. These findings suggest the possibility of gene expression level assessment in brain during the screening of promising treatments for OP poisoning.
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Sobre autores
Aleksandr Babkin
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Autor responsável pela correspondência
Email: noemail@neicon.ru
Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург, Российская Федерация
e-mail: babkinnik@yandex.ru
RússiaIrina Berdinskih
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Email: noemail@neicon.ru
Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург, Российская Федерация
e-mail: irina_berdinskih@mail.ru
RússiaNatalya Osechkina
Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency of Russia
Email: noemail@neicon.ru
Научный сотрудник ФГУН «Институт Токсикологии» ФМБА России, 192019, г. Санкт-Петербург, Российская Федерация
e-mail: dunats@rambler.ru
RússiaGeorgiy Nazarov
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Email: noemail@neicon.ru
Доктор химических наук, доцент, начальник отдела НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург, Российская Федерация
e-mail: denis-100@list.ru
RússiaMikhail Yudin
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Email: noemail@neicon.ru
Кандидат медицинских наук, доцент, заместитель начальника отдела НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация
e-mail: mikhail.judin@gmail.com
RússiaVladimir Bykov
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, начальник НИИЦ (МБЗ) НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация
e-mail: bykov_imm@yahoo.com
RússiaBibliografia
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