Bromination of 1(9)H-2,3-dihydroimidazo[1,2-a]benzimidazole and its N-derivatives

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2,3-Dihydro-1 H -imidazo[1,2- a ]benzimidazole in acetic acid, and its N 1-Me derivative in CHCl3, are brominated at position 6 with bromine. Less nucleophilic N 9-R derivatives do not enter into the reaction under these conditions, but, like their N 1-R isomers, they are quite effectively brominated by the KBrO3-HBr system, but at position 7, probably due to the transition of the reaction to the mode of bromination of protonated forms of substrates. N 1- and N 9-alkyl-6(7)-Br-2,3-dihydroimidazo[1,2- a ]benzimidazoles can also be obtained by N -alkylation of 6(7)-Br-2,3-dihydroimidazo[1,2- a ]benzimidazoles under neutral or basic conditions.

作者简介

V. Sochnev

Institute of Physical and Organic Chemistry, Southern Federal University

Email: vsochnev@sfedu.ru

Yu. Koshchienko

Institute of Physical and Organic Chemistry, Southern Federal University

T. Kuz'menko

Institute of Physical and Organic Chemistry, Southern Federal University

A. Kolodina

Institute of Physical and Organic Chemistry, Southern Federal University

G. Borodkin

Institute of Physical and Organic Chemistry, Southern Federal University

A. Morkovnik

Institute of Physical and Organic Chemistry, Southern Federal University

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