Synthesis and phosphonylation of 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine5-carboxylic acids ethyl esters

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Abstract

A new series of 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids ethyl esters was synthesized. The reaction of the obtained esters with dimethyl 2-chloroethynylphosphonate leads to the selective formation of new ethyl 3-(dimethoxyphosphoryl)-5-aryl-7-methyl-5 H -thiazolo[3,2- a ]pyrimidine-6-carboxylates.

About the authors

N. A. Nosova

St. Petersburg State Technological Institute (Technical University)

A. S. Skrylkova

St. Petersburg State Technological Institute (Technical University)

D. M. Egorov

St. Petersburg State Technological Institute (Technical University)

Email: diavoly@mail.ru

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