Analysis of coverage of Alu repeats by aligned genomic reads

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详细

Alu repeats occupy a notable part of the human genome and greatly affect processes related to genome integrity maintenance. One of the basic methods for studying variation in a genome, including Alu repeats is genome sequencing followed by mapping the sequenced reads to a reference genome sequence. The key feature of the read alignment is the depth of reference genome region coverage by mapped reads. In this paper, a new method is proposed for analyzing the coverage of Alu repeats and their flanking regions by whole-genome sequencing reads and the distribution of mean coverage in two aforementioned region types is explored.

作者简介

G. Tamazian

Institute of Translational Biomedicine, St. Petersburg State University

St. Petersburg, Russia

A. Kanapin

Institute of Translational Biomedicine, St. Petersburg State University

St. Petersburg, Russia

A. Samsonova

Institute of Translational Biomedicine, St. Petersburg State University

Email: a.samsonova@spbu.ru
St. Petersburg, Russia

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